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Cataldo AM, Peterhoff CM, Schmidt SD , Terio NB , Duff K, Beard M et al. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. Journal of Neuropathology & Experimental Neurology 2004 August;63(8):821-30.

Che, S., and Ginsberg , S.D. : Amplification of transcripts using terminal continuation. Lab Invest., 84: 131-137, 2004.

Choi SI, Vidal R, Frangione B, Levy E. Axonal transport of British and Danish amyloid peptides via secretory vesicles. FASEB Journal 2004 February;18(2):373-5.

Counts, S.E., Nadeem, M., Wuu, J., Ginsberg , S.D. , Saragovi, H.U., and Mufson, E.J.: Reduction of cortical TrkA but not p75NTR NGF receptor protein levels in early stage Alzheimerfs disease. Ann. Neurol., 56:520-531, 2004.

Dyakin VV, Bogart A, Estok K, Ardekani B, Duff K, Branch C, Wisniewski T, deLeon MJ, Wolf O, OfShea J, Wegiel J, Nixon RA. Magnetic resonance imaging assessment of neuropathology in a transgenic mouse model of Alzheimerfs disease. Magnetic Resonance in Medicine, 2004; 51:794-798.

Echeverria V, Ducatenzeiler A, Alhonen L, Janne J, Grant SM, Wandosell F, Muro A, Baralle F, Li H, Duff K, Szyf M, Cuello AC (2004) Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex. J Alzheimers Dis; 209-19.

Frederikse PH, Yun E, Kao HT, Zigler JS Jr, Sun Q, Qazi AS. Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Mol Vis. 2004 Oct 25;10:794-804.

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Ginsberg , S.D. , Elarova, I. , Ruben, M., Tan, F., Counts, S.E., Eberwine, J.H., Trojanowski, J.Q., Hemby, S.E., Mufson, E.J., and Che, S.: Single cell gene expression analysis: implications for neurodegenerative and neuropsychiatric disorders: Neurochem. Res., 29:1053-1064, 2004.

Gitler D, Xu Y, Kao HT, Lin D, Lim S, Feng J, Greengard P, Augustine GJ. Molecular determinants of synapsin targeting to presynaptic terminals. J Neurosci. 2004 Apr 7;24(14):3711-20.

Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A et al. Both the sequence and length of the C-terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. Journal of Biological Chemistry 2004 August 17;279(45):46455-63.

Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Sturchler-Pierrat C, Burki K, van Duinen SG, Maat-Schieman MLC, Staufenbiel M, Mathews PM, Jucker M. (2004) The amyloid precursor protein E693Q mutation targets neuronally produced Abeta to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis-Dutch type. Nature Neuroscience, 7:954-60.

Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B, Duff K, Branch C, Wisniewski T, de Leon MJ, Wolf O, O'Shea J, Nixon RA. (2004). MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magn Reson Med.; 51: 794-8.

Horikoshi Y, Sakaguchi G, Becker AG, Gray AJ, Duff K, Aisen PS, Yamaguchi H, Maeda M, Kinoshita N, Matsuoka Y. (2004) Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun.; 319: 733-7.

Jung S, Levy E. Murine cerebrovascular cells as a cell culture model for cerebral amyloid angiopathy: isolation of smooth muscle and endothelial cells from mouse brain. In: Sigurdsson EM, editor. Amyloid Proteins: Methods and Protocols.Totowa, NJ: Humana Press; 2004. p. 211-20.

King, S.R., Ginsberg , S.D. , Ishii, T., Smith, R.G., Parker, K.L., and Lamb, D.J.: The steroidogenic acute regulatory (StAR) protein is expressed in steroidogenic cells of the day-old (P1) brain. Endocrinology, 145:4775-4780, 2004.

Klein RL, Lin WL, Dickson DW, Lewis J, Hutton M, Duff K, Meyer EM, King MA. (2004). Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. Am J Pathol ;164: 347-53

Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T. (2004) Mostly Separate Distributions of CLAC- versus Abeta40- or Thioflavin -Reactivities in Senile Plaques Reveal Two Distinct Subpopulations of beta-Amyloid Deposits. Am J Pathol.; 165: 273-81.

Laudon H, Karlstrom H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J et al. Functional domains in presenilin 1: the Tyr-288 residue controls gamma -secretase activity and endoproteolysis. Journal of Biological Chemistry 2004 March 29.

Laudon H, Mathews PM, Karlstrom H, Bergman A, Farmery MR, Nixon RA et al. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. Journal of Neurochemistry 2004 April;89(1):44-53.

Lee S-P, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of s-Amyloid Plaques in a Transgenic Mouse Model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med 2004; 52:538-544.

Lemere C, Spooner E, LaFrancois J, Malester B, Mori C, Leverone J, Matsuoka Y, DeMattos R, Holzman D, Clements J, Selkoe D, Duff K (2004). Evidence of peripheral clearance of Abeta protein following chronic, active Ab immunization in PSAPP mice. Neurobiology of disease ;14:10-18.

Pastorino L, Ikin AF, Lamprianou S, Vacaresse N, Revelli JP, Platt K et al. BACE (beta-secretase) modulates the processing of APLP2 in vivo. Molecular & Cellular Neurosciences 2004 April;25(4):642-9.

Parvathy, Ehrlich M, Pedrini P, Diaz N, Lorenzo Refolo L, Buxbaum JD, Bogush A, Petanceska S, Gandy S. Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding. Journal of Neurochemistry 2004 August;90(4):1005-10.

Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD , Nixon RA et al. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide. Journal of Molecular Neuroscience 2004 February;22(1-2):13-8.

Porton B, Ferreira A, DeLisi LE, Kao HT. A rare polymorphism affects a Mitogen-Activated Protein kinase site in synapsin III: possible relationship to schizophrenia. Biological Psychiatry 2004 January 15;55(2):118-25.

Porton B, Kao HT. Effect of protein phosphorylation on neurite outgrowth in cultured embryonic Xenopus spinal neurons. Neurosignals 2003 January;12(1):45-52

Prelli F, Pawlik M, Frangione B, Levy E. Purification of human wild-type or variant cystatin C From conditioned media of transfected cells. In: Sigurdsson EM, editor. Amyloid Proteins: Methods and Protocols.Totowa, NJ: Humana Press; 2004. p. 221-6.

Sadowski M, Pankiewicz J, Scholtzova H, Yong J, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, and Wisniewski T. Amyloid-b deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. JNEN, 2004; 63:418-428.

Sadowski M, Pankiewicz J, Scholtzova H, Li YS, Quartermain D, Duff K, Wisniewski T.(2004) Links between the pathology of Alzheimer's disease and vascular dementia. Neurochem Res.; 6:1257-66.

Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V et al. Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiology of Aging 2004 September;25(8):1033-43.

Saura C, Choi SY, Malkani S, Shankaranarayana Rao B, Sun X, Chattarji S, Duff K, Kirkwood A and Shen J (2004). Synaptic dysfunction and age-dependent neurodegeneration caused by loss of presenilin function in the adult brain, Neuron; 42:23-36.

Schmidt SD , Jiang Y, Nixon RA, Mathews PM. Tissue processing prior to protein analysis and amyloid-ƒÀ quantitation. In: Sigurdsson EM, editor. Amyloid Proteins: Methods and Protocols.Totowa, NJ: Humana Press; 2004. p. 267-78.

Schmidt SD , Nixon RA, Mathews PM. ELISA method for measurement of amyloid-ƒÀ levels. In: Sigurdsson EM, editor. Amyloid Proteins: Methods and Protocols.Totowa, NJ: Humana Press; 2004. p. 279-98.

Siggurdsson E, Wadghiri Y, Elliott J, Pappolla M, Duff K, Turnbull D, Wisneiwski T. Detection of Alzheimerfs amyloid by magnetic resonance imaging, (2004) Magnetic Resonance in Medicine; 50:293-302.

Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O. Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Annals of Neurology 200

Tsai J, Grutzendle J, Duff,K, Gan WB (2004). Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches Nat Neurosci 7:1181-3.

Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa B, Peterhoff C, Cataldo A, Rudnicki A, Li B-S, Pant HC, Hungund L, Arancio O, Nixon RA. Calpain mediates calcium-induced activation of the Erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimerfs disease. AM J Path 2004; 165:795-805.

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Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD , Parker CA et al. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of Neurochemistry 2004 August;90(4):1011-8.

Yu WH, Kumar A, Peterhoff C, Shapiro Kulkane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA. Autophagic vacuoles are enriched in APP-secretase activities: Implications for Abeta peptide over-production and localization in Alzheimer's disease. International Journal of Biochemistry and Cell Biology 2004; 36:2531-2540.