Roussos Lab

Head of Lab

Panos Roussos, MD, PhD

Common neuropsychiatric illnesses, such as schizophrenia, bipolar disorder and Alzheimer’s disease, carry considerable morbidity, mortality, and personal and societal cost. While recent large-scale genetic association studies have identified numerous risk loci, the mechanisms through which they contribute to disease remain largely unknown.



By applying single cell molecular approaches to the affected tissue (in this case, the human brain), we can uncover novel cellular subpopulations that are associated with disease. In parallel, cell type-specific molecular studies allow us to characterize the effect of genetic variation on the 3-dimensional configuration of the genome and on the complex mechanisms that regulate gene expression in those cells relevant to disease. All these brain-specific multi-scale data are leveraged to interpret the genetic architecture of neuropsychiatric illnesses in large-scale biobank datasets. Our team is part of studies conducted by the Million Veteran Program, PsychENCODE project, CommonMind Consortium and Accelerating Medicine Partnership for Alzheimer’s Disease.

Selected Publications

Zeng B, Bendl J, Kosoy R, Fullard JF, Hoffman GE, Roussos P. Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits. Nat Genet. 2022 Jan 20. doi: 10.1038/s41588-021-00987-9. Epub ahead of print. PMID: 35058635.
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Kosoy R, Fullard JF, Zeng B, Bendl J, DongP, Rahman S, Kleopoulos SP, Shao Z, Humphrey J, Lopes KDP, Charney, Kopell BH, Raj T, Bennett D, Kellner CP, Haroutunian V, Hoffman GE, Roussos P. Genetics of the human microglia regulome refines Alzheimer’s disease risk loci. medRxiv. 2021 doi:10.1101/2021.10.17.21264910.
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Girdhar K, et al,. Acetylated chromatin Domains link chromosomal organization to cell-and circuit-level dysfunction in schizophrenia and bipolar disorder. 2021 bioRxiv 2021.06.02.446728; doi: https://doi.org/10.1101/2021.06.02.446728.
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Publications

All publications