Mark Burns, Ph.D.
Clinical Instructor
Department of Psychiatry
New York University School of Medicine
(845)398-5437
burns@nki.rfmh.org

Education

  • Ph.D. National University of Ireland, Galway (Pharmacology)

Postdoctoral Training

  • Center for Dementia Research, Nathan Kline Institute

Research Interests

I investigate the involvement of cholesterol in amyloid precursor protein processing in Alzheimer's disease. I also examine the subcellular compartment alterations involved in dementia.

Selected Publications

Burns, M., Gaynor, K., Olm, V., Mercken, M., LaFrancois, J., Wang, L., Mathews, P.M., Noble, W., Matsuoka, Y. and Duff, K. 2003. Presenilin redistribution associated with aberrant cholesterol transport enhances b-amyloid production in vivo. J Neurosci. 23 : 5645-5649

Burns, M., Noble, W.J., Olm, V., Gaynor, K., Casey, L. and Duff, K.E., 2003. Co-localization of cholesterol, apolipoprotein E and fibrillar A-beta in amyloid plaques. Brain Res Mol Brain Res. 110:119-25

Burns, M. and Duff, K.E. Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease, 2003. Neurochem Res. 28:979-86.

Burns, M. and Duff, K. Intracellular cholesterol homeostasis and Alzheimer's disease, 2003. In: "Alzheimer's disease and related disorders: Research Advances" Iqbal, K. and Winblad, B. (eds). 559-567

Burns, M. and Duff, K.E. Cholesterol in Alzheimer's disease and tauopathy, 2002. Ann NY Acad Sci. 977, 367-376

Noble, W., Olm, V., Takata, K., Casey, K., O, M., Meyerson, J., Gaynor, K., LaFrancois, J., Wang, L., Kondo, T., Davies, P.,
Burns, M., Matsuoka, Y., Ahlijanian, M., Lau, L-F., Duff, K. 2003. Hyperphosphorylation by CDK5 is a key pathogenic mechanism in tau aggregation and tangle formation. Neuron 38:555-565

Burns, M., Olm, V. and Duff, K.E. Apolipoprotein E, cholesterol and Alzheimer's disease, 2002. Neurobiology of Aging 23, S 401

Duff, K.E., Gaynor, K., Olm, V., Petanceska, S., Refolo, R. and
Burns, M. Cholesterol in Alzheimer's disease, 2002. Neurobiology of Aging 23, S 567