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Education
- Diploma in Biology at Universität zu Köln, Germany
(Specialization: Biochemistry, Molecular Biology, Developmental Biology)
- Ph.D. from the Department of Chemistry, Freie Universität Berlin, Germany
- Department of Neurosciences, UC San Diego
- Robert Koch-Institut (Berlin, Germany)
Any aspect of Alzheimer's disease, particularly functional changes on the protein level.
Currently, I am comparing mutated and normal Cystatin C in transgenic mice as trigger for cerebral amyloidosis and hemorrhage. I am still interested in the protein interactions of APP as well.
"Distinct Properties of Wild-type and the Amyloidogenic Human Cystatin C Variant of Hereditary Cerebral Hemorrhage with Amyloidosis, Icelandic Type" Calero, M., Pawlik, M., Soto, C., Castano, E., Sigurdsson, E. M., Kumar, A., Gallo, G., Frangione, B. and Levy, E.,
Journal of Neurochemistry 2001, 77, pp. 628-637
"Primate-like Amyloid-ß Sequence but Cerebral Amyloidosis in Aged Tree Shrews" Pawlik, M., Fuchs, E., Walker, L. C. and Levy, E.,
Neurobiology of Aging 1999, 20, pp. 47-51
"Induction of Signal Transducing Pathways by APP Binding to the Cell Surface Receptor" Saitoh, T., Jin, L.-W., Roch, J.-M. and Pawlik, M.,
Research Advances in Alzheimer’s Disease and Related Disorders, Eds: K.Iqbal,, J.Mortimer, B.Weinblad and H.Wisniewski 1995, pp. 693-699
(3H)Harman Binding Experiments. I: A Reversible and Selective Radioligand for Monoamine Oxidase Subtype A in CNS of the Rat, May, Torsten, Rommelspacher, Hans and Pawlik, Monika,
Journal of Neurochemistry 1990, 56, pp.490-499
("(3H)Harman Binding Experiments. I: A Reversible and Selective Radioligand for Monoamine Oxidase Subtype A in CNS of the Rat" May, T., Rommelspacher, H. and Pawlik, M.,
Journal of Neurochemistry 1990, 56, pp.500-508
"Quantitative Autoradiography of (3H)Norharman ((3H)ß-Carboline) Binding Sites in the Rat Brain" Pawlik, M., Kaulen, P., Baumgarten, H. G and Rommelspacher, H.,
Journal of Neuroanatomy 1990, 3, 19-24
"Demonstration of a Dinstinct Class of High-Affinity Binding Sites for (3H)Norharman ((3H)ß-Carboline) in the Rat Brain" Rommelspacher, H., Pawlik, M., and Strauss, S.,
European Journal of Pharmacology 1988, 147, pp.163-171
"Hemorrhages Caused by Overexpression of Cystatin C in Transgenic Mice" Pawlik, M., Danilov, V., Mancevska, K., Morbin, M., Tagliavini, F. and Levy, E.,
Neurobiology of Aging 2002, 23, p.S242
"Cystatin C Transgenic Mice, an Animal Model for Cerebral Hemorrhage" Levy, E. and Pawlik, M.,
Abstracts of the 31st Annual Meeting of the Society for Neuroscience 2001, 27, No 427.18
"Codeposition of Cystatin C with Amyloid-ß-Protein in the Brain of Alzheimer’s Disease Patients" Pawlik, M., Sastre, M., Kumar, A., Gallo, G., Ghetti, B., Tagliavini, F., and Levy, E.,
Neurobiology of Aging 2000, 21, p. S194
"Association of Cystatin C with Amyloid-ß-Protein" Calero, M., Sastre, M., Pawlik, M., Frangione, B. and Levy, E.,
Neurobiology of Aging, 2000, 21, p S533
"No Cerebral Amyloidosis in Aged Tree Shrews with Primate-like Amyloid-ß Sequence" Pawlik, M., Fuchs, E., Walker, L. C. and Levy, E.,
Abstracts of the 30th Meeting of the Society for Neuroscience 1999, 25 (1-2) No. 1859
"Neurite Extension Assay Detects the Defective Function due to Swedish Mutation in Amyloid ß/A4 Protein (APP)" Li, H. L., Roch, J.-M., Pawlik, M., Sisodia, S. and Saitoh, T.,
Abstracts of the 26th Annual Meeting of the Society for Neuroscience 1995, 21, No 671.3
"Induction of Signal Transducing Pathways by APP Binding to the Cell Surface Receptor" Saitoh, T., Jin, L.-W., Roch, J.-M. and Pawlik, M.,
Neurobiology of Aging 1994, 15, Supplement 1, No 654,
"(3H)Harman Binds Selectively and with High Affinity to Monoamine Oxidase (EC 1.4.3.4) Subtype A in Rat and Marmoset" May, T., Pawlik, M. and Immendörfer, U.,
Naunyn-Schmiedberg’s Archives of Pharmacology 1990, 341, Supplement No. 385,
"Are there Specific ß-Carboline Receptors in Rat Brain?" Rommelpacher, H., Pawlik, M., and Strauss, S.,
Naunyn-Schmiedberg’s Archives of Pharmacology 1988, 337, Supplement No. 461,
"High Affinity Binding Sites for (3H)Norharman (ß-Carboline) in Rat Brain" Pawlik, M.,
Naunyn-Schmiedberg’s Archives of Pharmacology 1987, 337, Supplement No. 383,
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