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Education
- B.S.University of Mysore, Mysore, India (Chemistry, Botany, Zoology)
- M.S.Bangalore University, Bangalore, India (Zoology)
- Ph.D. Bangalore University, Bangalore, India (Neurochemistry)
- Research Associate, University of Illinois, Chicago
- Visiting Fellow, Lab. Neurochemistry NINDS, NIH, Bethesda, MD
- Visiting Associate, Lab. Neurochemistry NINDS, NIH, Bethesda, MD
- Research Fellow, Lab. Neurochemistry NINDS, NIH, Bethesda, MD
- 1999 Special Achievement Award, National Institute of Neurological Disorders and Stroke, National Institutes of Health
My interests include the molecular mechanisms underlying cell signaling and neurodegeneration, with special reference to cytoskeletal phosphorylation.
Aberrant phosphorylation of the cytoskeleton is a pathological hallmark of several neurodegenerative disorders. Currently we are investigating the following aspects of protein phosphorylation in the brain: kinases and phosphatases responsible for neurofilament phosphorylation in health and disease (using primary and transformed cells in culture, mouse models and autopsy tissues from human patients); factors that trigger and govern cytoskeletal phosphorylation through signaling cascades and their spatial and temporal regulation during neuronal development and aging; implications of domain-specific phosphorylation of cytoskeletal proteins for modulating neuronal cytoskeletal assembly, interactions, transport and turnover.
Sharma P, Veeranna, Sharma M, Amin ND, Sihag RK, Grant P, Ahn N, Kulkarni AB, Pant HC. 2002. Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway. J Biol Chem. 277: 528-534. [P. Sharma and Veeranna contributed equally to this work]
Ohshima T, Ogawa M, Veeranna, Hirasawa M, Longenecker G, Ishiguro K, Pant HC, Brady RO, Kulkarni AB, Mikoshiba K. Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2001 98(5):2764-2769.
Tanaka T, Veeranna, Ohshima T, Rajan P, Amin N, Cho A, Sreenath T, Pant H, Brady R, Kulkarni A. Neuronal cyclin-dependent kinase activity is critical for survival. J Neurosci. 2001 21(2):550-8.[T. Tanaka and Veeranna contributed equally to this paper]
Pant HC, Veeranna , Grant P. Regulation of axonal neurofilament phosphorylation. Curr Top Cell Regul. 2000;36:133-50.
Veeranna, Shetty KT, Takahashi M, Grant P, Pant HC. Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain. Brain Res Mol Brain Res. 2000 76(2):229-36.
Pant MK, Veeranna, Amin ND, Amin N, Pant HC. Phosphorylation Activity in the Alzheimer’s Disease and Normal Brain is Modulated by Microtubule-Associated Protein, Tau in vitro. J. Alzheimer’s Disease 1 (1999):169-182.
Li BS, Veeranna, Grant P, Pant HC. Calcium influx and membrane depolarization induce phosphorylation of neurofilament (NF-M) KSP repeats in PC12 cells. Brain Res Mol Brain Res. 1999 70(1):84-91.
Li BS, Veeranna, Gu J, Grant P, Pant HC. Activation of mitogen-activated protein kinases (Erk1 and Erk2) cascade results in phosphorylation of NF-M tail domains in transfected NIH 3T3 cells. Eur J Biochem. 1999 262(1):211-7.
Jaffe H, Veeranna, Pant HC. Characterization of serine and threonine phosphorylation sites in beta-elimination/ethanethiol addition-modified proteins by electrospray tandem mass spectrometry and database searching. Biochemistry. 1998 37(46):16211-24.
Veeranna, Amin ND, Ahn NG, Jaffe H, Winters CA, Grant P, Pant HC. Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M. J Neurosci. 1998 18(11):4008-21.
Jaffe H, Veeranna, Shetty KT, Pant HC. Characterization of the phosphorylation sites of human high molecular weight neurofilament protein by electrospray ionization tandem mass spectrometry and database searching. Biochemistry. 1998 37(11):3931-40.
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