Postdoctoral Training
Research Interests Mechanisms controlling neuronal cell death in Alzheimer's disease. Understanding the underlying abnormalities in the endosomal/lysosomal system of neurons in Alzheimer's disease. Selected Publications Boland B, Campbell V (2004) Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L. Neurobiol Aging 25:83-91. Boland B, Campbell V (2003) beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase. Neurobiol Aging 24:179-186. Link to Abstract Downer E, Boland B, Fogarty M, Campbell V (2001) Delta 9-tetrahydrocannabinol induces the apoptotic pathway in cultured cortical neurones via activation of the CB1 receptor. Neuroreport 12:3973-3978. Link to Abstract Martin DS, Lonergan PE, Boland B, Fogarty MP, Brady M, Horrobin DF, Campbell VA, Lynch MA (2002) Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid. J Biol Chem 277:34239-34246. Link to Abstract Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa BS, Peterhoff C, Cataldo A, Rudnicki A, Amin N, Li BS, Pant HC, Hungund BL, Arancio O and Nixon RA (2004) Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. Am J Pathol.165:795-805. |
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