- M.D. Shanghai Medical University, Shanghai, China
- M.S. Dept. of Biochemistry, Shanghai Medical University, Shanghai, China
- Ph.D. Dept. of Microbiology and Immunology, Baylor College of Medicine, Houston, TX
- Dept. of Clinical Investigation, University of Texas, MD Anderson Cancer Center, Houston, Texas
- Dept. of Geropsychiatry, Houston Veterans Affairs Medical Center, Houston, Texas
- Departments of Pediatrics, Baylor College of Medicine, Houston, Texas
- Center for Dementia Research, Nathan Kline Institute
I am a pathologist and molecular biologist with a particular interest in genetics and proteomics. I have helped develop new terminal continuation (TC) RNA amplification methodology. My lab (Ginsberg Laboratory) is also developing technically challenging cDNA microarray technology using single cells from mouse models of neurodegeneration and human postmortem brain samples.
Original Peer Reviewed Articles:
1) Che, S., and Ginsberg, S.D.: Amplification of RNA transcripts using terminal continuation. Submitted for publication.
2) Ginsberg, S.D., Che, S. RNA amplification in brain tissues. Neurochem Res. 27:981-92, 2002.
3) Wu, Y., Pan, S., Che, S., He, G., Nelman-Gonzalez, M., Weil, M.M., Kuang, J.: Overexpression of Hp95 induces G1 phase arrest in confluent HeLa cells. Differentiation, 67:139-53, 2001.
4) Che, S., El-Hodiri, H.M., Wu, C.F., Nelman-Gonzalez, M., Well, M.M., Etkin, L.D., Clark, R.B., Kuang, J:. Identification and cloning of xp95, a putative signal transduction protein in Xenopus oocytes. J. Biol. Chem., 274: 5522-5531, 1999.
5) Che, S., Wu, W., Nelman-Gonzalez, M., Stukenberg, T., Clark, R., Kuang, J.A.: Phosphatase activity in Xenopus oocyte extracts preferentially dephosphorylates the MPM-2 epitope. FEBS Lett. 424: 225-323, 1998.
6) Che, S., Weil, M.M., Etkin, L.D., Epstein, H.F., Kuang, J.: Molecular cloning of a splice variant of Caenorhabditis elegans YNK1, a putative element in signal transduction. Biochim. Biophys. Acta 1354: 231-240, 1997.
7) Che, S., Weil, M.M., Nelman-Gonzalez, M., Ashom, C.L., Kuang, J.: MPM-2 epitope sequence is not sufficient for recognition and phosphorylation by ME kinase-H. FEBS Lett., 413: 417-423, 1997.
8) EI-Hodiri, H.M., Che, S., Nelman-Gonzalez, M., Kuang, J., Etkin, L.D.: Mitogen-activated protein kinase and cyclin B/Cdc2 phosphorylate Xenopus nuclear factor 7 (xnf7) in extracts from mature oocytes. Implications for regulation of xnf7 subcellular localization. J. Biol. Chem., 272: 20463-20470, 1997.
9) Tai, P.C., Banik, D., Lin, G.I., Pai, S., Pai, K., Lin, M.H., Yuoh, G., Che, S., Hsu, S.H., Chen, T.C., Kuo, T.T., Lee, C.S., Yang, C.S., Shih, C.: Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen. Virol., 71: 4852-4858, 1997.
10) Shou, W., Li, X., Wu, C., Cao, T., Kuang, J., Che, S., Etkin, L.D.: Finely tuned regulation of cytoplasmic retention of Xenopus nuclear factor 7 by phosphorylation of individual threonine residues. Mol. Cell Biol., 16: 990-997, 1996.
11) Che, S., Huston, D.P.: Natural killer cell suppression of IgM production. Nat. Immunol., 13: 258-269, 1994.
Abstracts:
1) Che, S., and Ginsberg, S.D.: Amplification of RNA transcripts using terminal continuation (TC) in aging and Alzheimer's disease. Proc. Soc. Neurosci., 28: 686.12, 2002.
2) Elarova, I., Che, S., and Ginsberg, S.D.: Expression profile analysis of hippocampal neurons in Alzheimer's disease and normal aging. Proc. Soc. Neurosci., 28: 686.11, 2002.
3) Mufson, E.J., Counts, S.E., Che, S., and Ginsberg, S.D.: Expression profiles of cytoskeletal mRNAs in cholinergic nucleus basalis neurons in people with mild cognitive impairment and Alzheimers disease. Proc. Soc. Neurosci., 28: 686.10, 2002.
4) Che, S., Wu, W., Nelman-Gonzalez, M., Stukenberg, T., Clark, R., Kuang, J.: A subtype of type 2A phosphatase dephosphorylates the mitotically phosphorylated epitope recognized by the MPM-2 antibody. Keystone Symposia, 1997.
5) Che, S., Well, M.M., Etkin, L.D., Epstein, H.F., Kuang, J.C.: Elegans YNK1 and Xenopus Xp95 are homologous proteins implicated in signal transduction. Keystone Symposia, 1996.
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