Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP βCTF.
Sci Adv.
2023 Jul 28;9(30):eadg1925. doi: 10.1126/sciadv.adg1925. Epub 2023 Jul 26. PubMed PMID:
37494443; PubMed Central PMCID:
PMC10371027.
Autophagy is a novel pathway for neurofilament protein degradation in vivo.
Autophagy.
2023 Apr;19(4):1277-1292. doi: 10.1080/15548627.2022.2124500. Epub 2022 Sep 21. PubMed PMID:
36131358; PubMed Central PMCID:
PMC10012948.
Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis.
Autophagy.
2022 Nov;18(11):2763-2764. doi: 10.1080/15548627.2022.2110729. Epub 2022 Aug 23. PubMed PMID:
35947489; PubMed Central PMCID:
PMC9629058.
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques.
Nat Neurosci.
2022 Jun;25(6):688-701. doi: 10.1038/s41593-022-01084-8. Epub 2022 Jun 2. PubMed PMID:
35654956; PubMed Central PMCID:
PMC9174056.
Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca(2+) efflux and disrupted by PSEN1 loss of function.
Sci Adv.
2022 Apr 29;8(17):eabj5716. doi: 10.1126/sciadv.abj5716. Epub 2022 Apr 29. PubMed PMID:
35486730; PubMed Central PMCID:
PMC9054012.
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Cell Rep.
2020 Nov 24;33(8):108420. doi: 10.1016/j.celrep.2020.108420. PubMed PMID:
33238112; PubMed Central PMCID:
PMC7714675.
β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7.
J Mol Biol.
2020 Apr 3;432(8):2633-2650. doi: 10.1016/j.jmb.2020.02.021. Epub 2020 Feb 24. PubMed PMID:
32105735; PubMed Central PMCID:
PMC7211125.
Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo.
Autophagy.
2019 Mar;15(3):543-557. doi: 10.1080/15548627.2018.1528812. Epub 2018 Oct 26. PubMed PMID:
30269645; PubMed Central PMCID:
PMC6351128.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy.
2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. PubMed PMID:
26799652; PubMed Central PMCID:
PMC4835977.
Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.
Cell Rep.
2015 Sep 1;12(9):1430-44. doi: 10.1016/j.celrep.2015.07.050. Epub 2015 Aug 20. PubMed PMID:
26299959; PubMed Central PMCID:
PMC4558203.
Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo.
Mol Psychiatry.
2015 Aug;20(8):986-94. doi: 10.1038/mp.2015.45. Epub 2015 Apr 14. PubMed PMID:
25869803; PubMed Central PMCID:
PMC4514553.
Functions of neurofilaments in synapses.
Mol Psychiatry.
2015 Aug;20(8):915. doi: 10.1038/mp.2015.99. PubMed PMID:
26201270; PubMed Central PMCID:
PMC6211566.
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification.
Eur J Neurosci.
2013 Jun;37(12):1949-61. doi: 10.1111/ejn.12169. PubMed PMID:
23773064; PubMed Central PMCID:
PMC3694736.
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy.
2012 Apr;8(4):445-544. doi: 10.4161/auto.19496. PubMed PMID:
22966490; PubMed Central PMCID:
PMC3404883.
Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments.
Neurobiol Aging.
2011 Nov;32(11):2016-29. doi: 10.1016/j.neurobiolaging.2009.12.001. Epub 2009 Dec 23. PubMed PMID:
20031277; PubMed Central PMCID:
PMC2891331.
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
Cell.
2010 Jun 25;141(7):1146-58. doi: 10.1016/j.cell.2010.05.008. Epub 2010 Jun 10. PubMed PMID:
20541250; PubMed Central PMCID:
PMC3647462.
Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases.
Methods Enzymol.
2009;453:111-44. doi: 10.1016/S0076-6879(08)04006-8. PubMed PMID:
19216904.
Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases.
J Neurochem.
2008 Oct;107(1):35-49. doi: 10.1111/j.1471-4159.2008.05547.x. Epub 2008 Jul 4. PubMed PMID:
18715269; PubMed Central PMCID:
PMC2941900.
Neurodegenerative lysosomal disorders: a continuum from development to late age.
Autophagy.
2008 Jul;4(5):590-9. doi: 10.4161/auto.6259. Epub 2008 May 12. Review. PubMed PMID:
18497567.
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
J Cell Biol.
2005 Oct 10;171(1):87-98. doi: 10.1083/jcb.200505082. Epub 2005 Oct 3. PubMed PMID:
16203860; PubMed Central PMCID:
PMC2171227.
The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.
J Biol Chem.
2004 Nov 19;279(47):49099-104. doi: 10.1074/jbc.M405602200. Epub 2004 Sep 3. PubMed PMID:
15347685.
The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.
J Biol Chem.
2003 Nov 21;278(47):47025-9. doi: 10.1074/jbc.M300503200. Epub 2003 Sep 11. PubMed PMID:
12970358.
Self-oligomerization and protein aggregation of alpha-synuclein in the presence of Coomassie Brilliant Blue.
Eur J Biochem.
2001 Jan;268(2):295-301. doi: 10.1046/j.1432-1033.2001.01877.x. PubMed PMID:
11168363.
Eosin interaction of alpha-synuclein leading to protein self-oligomerization.
Biochim Biophys Acta.
2000 Aug 31;1481(1):139-46. doi: 10.1016/s0167-4838(00)00106-0. PubMed PMID:
11004584.
Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.
Arch Biochem Biophys.
2000 Jun 15;378(2):269-77. doi: 10.1006/abbi.2000.1822. PubMed PMID:
10860544.
Copper(II)-induced self-oligomerization of alpha-synuclein.
Biochem J.
1999 Jun 15;340 ( Pt 3)(Pt 3):821-8. PubMed PMID:
10359669; PubMed Central PMCID:
PMC1220316.
Comparisons of the NACP self-oligomerizations induced by Abeta25-35 in the presence of dicyclohexylcarbodiimide and N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline.
Neurochem Res.
1998 Nov;23(11):1427-34. doi: 10.1023/a:1020711025418. PubMed PMID:
9814554.
Self-oligomerization of NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer's disease amyloid, observed in the presence of a C-terminal A beta fragment (residues 25-35).
FEBS Lett.
1998 Jan 2;421(1):73-6. doi: 10.1016/s0014-5793(97)01537-8. PubMed PMID:
9462843.
Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid.
Arch Biochem Biophys.
1997 Aug 15;344(2):325-34. doi: 10.1006/abbi.1997.0207. PubMed PMID:
9264546.
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