Publications for Ju Hyun Lee, PhD

Requests for papers can be made by emailing Ju Hyun.

Original Publications

  1. Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA. Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci 2013, 37(12):1949-61. PMID:23773064 PMCID: PMC3694736 Click for abstract
  2. Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vincente M, Massey AC, Sovak G, Uchiyama Y, Westway D, Cuervo AM, Nixon RA. Lysosomal proteolysis and autophagy require Presenilin 1 and are disrupted by Alzheimer’s related PS1 mutations. Cell, 2010, 14(7):1146-1158. PMID:20541250 PMCID: PMC3647462 Click for abstractPDF
  3. Veeranna, Yang DS, Lee JH, Vinod KY, Stavrides P, Amin ND, Pant HC, and Nixon RA. (2011) Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol. Aging. 32(11):2016-29. Click for abstract
  4. Veeranna, Lee JH, Pareek TK, Jaffee H, Boland B, K. Vinod Y, Amin N, Kulkarni A, Pant HC, and Nixon RA. (2008) Neurofilament tail phosphorylation: Identity of the RT97 phosphoepitope and regulation in neurons by crosstalk among proline-directed kinases. J. Neurochem. 170:35-49. Full text avilable:
  5. Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Naslund J, Mathews PM, Cataldo AM, Nixon RA. (2005) Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J. Cell. Biol. 171:87-98. Full text available:
  6. Lee JH, Lau KF, Perkinton MS, Standen C, Boris R, Agnieszka F, McLoughlin DM, and Miller CC (2004) The neuronal adaptor protein X11b reduces Ab levels and amyloid plaque formation in the brains of transgenic mice. J. Biol. Chem., 279:49099-49104. Full text available:
  7. Lee JH, Lau KF, Perkinton MS, Standen C, Shemilt S, Mercken L, Cooper J, McLoughlin DM, and Miller CC (2003) The neuronal adaptor protein X11a reduces Ab levels in the brains of Alzheimer's APPswe, Tg2576 transgenic mice.  J. Biol. Chem., 278:47025-47029. Full text available:
  8. Lee D, Lee EK, Lee JH, Chang CS, Paik SR (2001) Self-oligomerization and protein aggregation of alpha-synuclein in the presence of Coomassie Brilliant Blue. Eur J Biochem 268:295-301. Full text available:
  9. Shin HJ, Lee EK, Lee JH, Lee D, Chang CS, Kim YS, Paik SR (2000) Eosin interaction of alpha-synuclein leading to protein self-oligomerization. Biochim Biophys Acta. 1481(1): 139-146. Click for abstract
  10. Paik SR, Shin HJ, Lee JH. (2000) Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper (II) and hydrogenperoxide. Arch Biochem Biophys. 378: 269-277. Click for abstract
  11. Paik SR, Shin HJ, Lee JH, Chang CS, Kim J. (1999) Copper (II)-induced self-oligomerization of alpha-synuclein. Biochem J. 340:821-828. Full text available:
  12. Lee JH, Shin HJ, Chang CS, Paik SR. (1998) Comparisons of the NACP self-oligomerizations induced by Ab25-35 in the presence of dicyclohexylcarbodiimide and N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline. Neurochem Res. 23:1427-1434. Click for abstract
  13. Paik SR, Lee JH, Kim DH, Chang CS, Kim YS. (1998) Self-oligomerization of NACP, the precursor protein of the non-amyloid beta/A4 protein (Ab) component of Alzheimer's disease amyloid, observed in the presence of a C-terminal Ab fragment (residues 25-35). FEBS Lett. 421:73-76. Click for abstract
  14. Paik SR, Lee JH, Kim DH, Chang CS, Kim J. (1997) Aluminum-induced structural alterations of the precursor of the non-Ab component of Alzheimer's disease amyloid. Arch Biochem Biophys. 344:325-334. Click for abstract

Reviews, Books, and Book Chapters

  • Yang DS, Lee JH, Nixon RA. (2009) Chapter 6: Monitoring Autophagy in Alzheimer's Disease and Related Neurodegenerative Diseases. Methods in Enzymology. 453C: 111-144.
  • Nixon RA, Yang DS, Lee JH (2008) Neurodegenerative lysosomal disorders – a continuum from development to late age. Autophagy 4:590-9. Full text available:

[last updated 11.20.14]