Publications for Efrat Levy, PhD

Requests for papers can be made by emailing Efrat Levy.

Original Publications

  • Hochman J, Katz A, Levy E, Eshel S. Cell substrate adhesiveness in S49 mouse lymphoma. Cell Biol Intern Reports 1980;4:953-959. PMID: 7418013 Click for abstract
  • Hochman J, Katz A, Levy E, Eshel S.  Substrate adhering lymphoid cells show impaired tumorigenicity and increased immunogenicity. Nature 1981;290:248-249. PMID: 7207615 Click for abstract
  • Hochman J, Levy E, Mador N, Gottesman MM, Shearer GM, Okon E.  Cell adhesiveness is related to tumorigenicity in malignant lymphoid cells. J Cell Biol 1984;99:1281-1288. PMID: 6480692 HTML PDF
  • Stark AA, Hochman J, Levy E, Barr-Nea L, Goldschmied-Reouven A, Amizur M.  g-Glutamyltranspeptidase in murine lymphomas. Eur J Cancer Clin Oncol 1986;22:77-87. PMID: 2869949 Click for abstract
  • Loren JJ, Levy E, Ozato K, Hochman J, Shearer GM.  Differential lack of class I-H-2d antigen expression by sublines of the Balb/cS49 T-cell lymphoma. J Immunol 1986;137:4016-4020. PMID: 3491154 Click for abstract
  • Levy E, Liem RKH, D'Eustachio P, Cowan NJ.  Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular mass neurofilament protein. Eur J Biochem 1987;166:71-77. PMID: 3036526 HTML PDF
  • Levy E, Lopez-Otin C, Ghiso J, Geltner D, Frangione B.  Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases. J Exp Med 1989;169:1771-1778. PMID: 2541223 HTML PDF
  • Levy E, Carman MD, Fernandez-Madrid I, Lieberburg I, Power MD, van Duinen SG, Bots GThAM, Luyendijk W, Frangione B.  Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990;248:1124-1126. PMID: 2111584 Click for abstract
  • Prelli F, Levy E, van Duinen SG, Bots GThAM, Luyendijk W, Frangione B.  Expression of a normal and variant Alzheimer's b-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays. Biochem Biophys Res Commun 1990;170:301-307. PMID: 2196878 Click for abstract
  • Levy E, Haltia M, Fernandez-Madrid I, Koivunen O, Ghiso J, Prelli F, Frangione B.  Mutation in gelsolin gene in Finnish hereditary amyloidosis. J Exp Med 1990;172:1865-1867. PMID: 2175344 HTML PDF
  • Bakker E, van Broeckhoven C, Haan J, Voorhoeve E, van Hul W, Levy E, Lieberburg I, Carman MD, van Ommen GJB, Frangione B, Roos RAC.  DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type). Am J Hum Genet 1991;49:518-521.HTML PDF
  • Fernandez-Madrid I, Levy E, Marder K, Frangione B.  Codon 618 variant of Alzheimer amyloid gene associated with inherited cerebral hemorrhage. Ann Neurol 1991 ;30:730-733. Click for abstract
  • Gorevic PD, Munoz PC, Gorgone G, Purcell Jr JJ, Rodrigues M, Ghiso J, Levy E, Haltia M, Frangione B.  Amyloidosis due to a mutation of the gelsolin gene in an American family with lattice corneal dystrophy type II. New Engl J Med 1991;325:1980-1785. HTML PDF
  • Haltia M, Levy E, Meretoja J, Fernandez-Madrid I, Koivunen O, Frangione B.  Gelsolin gene mutation - at codon 187 - in familial amyloidosis, Finnish type: DNA-diagnostic assay. Am J Med Gen 1992;42:357-359. Click for abstract
  • Vidal RG, Fernandez-Madrid I, Frangione B, Levy E.  Cloning, characterization and sequencing of the Alzheimer's APP gene Dutch variant (APP-D). Hum Mut 1993;2:495. [abstract not available]
  • Wisniewski T, Lalowski M, Levy E, Marques MRF, Frangione B.  The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient. Ann Neurol 1994;35:245-246. [abstract not available]
  • Haltia M, Viitanen M, Sulkava R, Ala-Hurula V, Poyhonen M, Goldfarb L, Brown P, Levy E, Houlden H, Crook R, Alison G, Clark R, Korenblat K, Pandit S, Keller HD, Lilius L, Liu L, Axelman K, Forsell L, Lannfelt L, Hardy J.  Chromosome 14 encoded Alzheimer's disease: genetic and clinicopathological description. Ann Neurol 1994;36:362-367. Click for abstract
  • Wisniewski DS, Morelli L, Wegiel J, Levy E, Wisniewski HM, Frangione B.  The influence of Apolipoprotein E isotypes on Alzheimer's disease pathology in 40 cases of Down's syndrome. Ann Neurol 1995;37:136-138. PMID: 7818249 [abstract not available]
  • Mangone CA, Castaño EM, Levy E, Abiusi G, Wisniewski T, Marques MR, Faccio E, Gorelick PB, Frangione B, Sica REP.  Early onset Alzheimer's disease in a South American pedigree from Argentina. Acta Neurol Scand 1995;91:6-13. PMID: 7732777 Click for abstract
  • Levy E, Amorim AF, Frangione B, Walker LC.  Beta-amyloid precursor protein gene in squirrel monkeys with cerebral amyloid angiopathy. Neurobiol Aging 1995;16:805-808. PMID: 8532114 Click for abstract
  • Graffagnino C, Herbstreith MH, Schmechel DE, Levy E, Roses AD, Alberts MJ.  Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage. Stroke 1995;26:2190-2193. PMID: 7482672HTML[No PDF available]
  • Morelli L, Wei L, Amorim A, McDermid J, Abee CR, Frangione B, Walker LC, Levy E.  Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype. FEBS Letters 1995;379:132-134. PMID: 8635577 Click for abstract
  • Baumann MH, Wisniewski T, Levy E, Plant GT, Ghiso J.  C-terminal fragments of alpha- and beta- tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. Biochem Biophys Res Commun 1996;219:238-242. PMID: 8619814 Click for abstract
  • Wei L, Walker LC, Levy E.  Cystatin C: Icelandic-like mutation in an animal model of cerebrovascular beta-amyloidosis. Stroke 1996;27:2080-2085. PMID: 8898820 HTML [No PDF available]
  • Borg J-P, Ooi J, Levy E, Margolis B.  The PI domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol Cel Biol 1996;16:6229-6241. PMID: 8887653, PMCID: PMC231626HTML PDF
  • Islam K, Levy E.  Carboxyl-terminal fragments of beta-amyloid precursor protein bind to microtubules and the associated protein tau. Am J Pathol 1997;151:265-271. PMID: 9212751, PMCID: PMC1857905HTML PDF
  • Wei L, Berman Y, Castaño EM, Cadene M, Beavis RC, Devi L, Levy E.  Instability of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. J Biol Chem 1998;273:11806-11814. HTML PDF
  • Sastre M, Turner RS, Levy E.  X11 interaction with b-amyloid precursor protein modulates its cellular stabilization and reduces amyloid b-protein secretion. J Biol Chem 1998;273:22351-22357. PMID: 9712855HTML PDF
  • Morelli L, Prat, MI, Levy E, Mangone CA, Castaño EM.  Presenilin 1 Met146 Leu variant due to an A_T transition in an early onset familial Alzheimer disease pedigree from Argentina. Clin Genet 1998;53:469-473. PMID: 9712537 Click for abstract
  • Saborío GP, Soto C, Kascsak RJ, Levy E, Kascsak R, Harris DA, Frangione B.  Cell-lysate conversion of prion protein into its protease-resistant isoform suggests the participation of a cellular chaperone. Biochem Biophys Res Commun 1999;258:470-475. PMID: 10329411 Click for abstract
  • Pawlik M, Fuchs E, Walker L C, Levy E.  Primate-like amyloid-beta sequence but no cerebral amyloidosis in aged tree shrews. Neurobiol Aging 1999;20:47-51. PMID: 10466892 Click for abstract
  • Levy E, Sastre M, Kumar A, Gallo G, Piccardo MD, Ghetti B, Tagliavini F.  Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer's disease patients. J Neuropath Exp Neur 2001;60:94-104. PMID: 11202179 Click for abstract
  • Calero M, Pawlik M, Soto C, Castaño EM, Sigurdsson E, Kumar A, Gallo G, Frangione B, Levy E.  Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. J Neurochem 2001;77:628-637. PMID: 11299325 Click for abstract
  • Choi SI, Vidal R, Frangione B, Levy E.  Axonal transport of British and Danish amyloid peptides via secretory vesicles. The FASEB J express (published on line December 4, 2003) 2004;18:373-375. PMID: 14656991HTML PDF
  • Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD, Nixon RA, Levy E.  Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid beta peptide. J Mol Neurosc 2004;22:13-18. PMID: 14742906 Click for abstract
  • Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V, Schmidt SD, Nixon RA, Frangione B, Levy E.  Binding of cystatin C to Alzheimer’s amyloid beta inhibits amyloid fibril formation. Neurobiol Aging 2004;25:1033-1043. PMID: 15212828 Click for abstract
  • Pawlik M, Otero DAC, Park M, Fischer WH, Levy E, Saitoh T.  Proteins that bind to the RERMS region of beta amyloid precursor protein. Biochem Biophys Res Commun 2007;355(4):907-912. PMID: 17335780, PMCID: PMC1896148HTML PDF
  • Gandy S, Zhang Y, Ikin A, Schmidt SD, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME.  Alzheimer's presenilin 1 modulates trafficking of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. J Neurochem 2007;102(3):619-626. PMID: 17630980 Click for abstract
  • Kaeser SA, Herzig MC, Coomaraswamy J, Kilger JE, Selenica M-LB, Winkler DT, Staufenbiel M, Levy E, Grubb A, Jucker M.  Cystatin C modulates cerebral beta-amyloidosis. Nature Gen 2007;39(12):1437-1439. PMID: 18026102 Click for abstract
  • Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky D, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid beta deposition in Alzheimer’s disease mouse models. Nature Gen 2007;39(12):1440-1442. PMID: 18026100 Click for abstract
  • Yang D-S, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M, Levy E, Cataldo AM, Nixon RA. Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer’s disease. Am J Pathol 2008;173(3):665-81. PMID: 18688038 PMCID: PMC2527090HTML PDF
  • Levine S, Saltzman A, Levy E, Ginsberg SD. Systemic pathology in aged mouse models of Down’s syndrome and Alzheimer’s disease. Exp Mol Pathol 2009;86(1):18-22. PMID: 19041304, PMCID: PMC2659493HTML PDF
  • Di Fede G, Catania M, Morbin M, Rossi G, Suardi S, Mazzoleni G, Merlin M, Giovagnoli AR, Prioni S, Erbetta A, Falcone C, Gobbi M, Colombo L, Bastone A, Beeg M, Manzoni C, Francescucci B, Spagnoli A, Cantù L, Del Favero E, Levy E, Salmona M, Tagliavini F. A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis. Science 2009;323(5920):1473-1477. PMID: 19286555, PMCID: PMC2728497HTML PDF
  • Mi W, Jung SS, Yu H, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E. Complexes of amyloid beta and cystatin C in the human central nervous system. J Alzheimer Dis 2009;18(2):273-280. PMID: 19584436, PMCID: PMC2792995HTML PDF
  • Choi JHK, Berger JD, Mazzella MJ, Morales-Corraliza J, Nixon RA, Ginsberg SD, Levy E, Mathews PM. Age-dependent dysregulation of brain APP in the Ts65Dn Down syndrome mouse model. J Neurochem 2009;110:1818-1827. PMID: 19619138, PMCID: PMC2744432HTML PDF
  • Morales-Corraliza J, Diaz NS, Berger JD, Mazzella MJ, Choi JHK, Levy E, Matsuoka Y, Planel E, Mathews PM. In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the b-amyloid depositing mice. PLoS One 2009;4(9):e7134. PMID: 19771166, PMCID: PMC2741602HTML PDF
  • Ghidoni R, Paterlini A, Albertini V, Glionna M, Monti E, Schiaffonati L, Benussi L, Levy E, Binetti G. Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer’s Disease. Neurobiol Aging 2011;32(8):1435-1442. PMID: 19773092, PMCID: PMC2891183 HTML PDF
  • Tizon B, Ribe EM, Mi W, Troy CM, Levy E. Cystatin C protects neuronal cells from amyloid beta-induced toxicity. J Alzheimer Dis 2010;19:885-894. PMID: 20157244, PMCID: PMC2889175HTML PDF
  • Taddei K, Laws SM, Verdile G, Munns S, D'Costa K, Harvey AR, Martins IJ, Hill F, Levy E, Shaw JE, Martins RN. Novel phage peptides attenuate amyloid b42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiol Aging 2010;31(2):203-214. PMID: 18472186 Click for abstract
  • Wesson DW, Levy E, Nixon RA, Wilson DA. Olfactory dysfunction correlates with amyloid-β burden in an Alzheimer’s Disease mouse model. J Neurosc 2010;30(2):505-514. PMID: 20071513, PMCID: PMC2826174HTML PDF
  • Tizon B, Sahoo S, Yu H, Gauthier S, Kumar AR, Mohan P, Figliola M, Pawlik M, Grubb A, Uchiyama Y, Bandyopadhyay U, Cuervo AM, Nixon RA, Levy E. Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PLoS One 2010; 5(3):e9819. PMID: 20352108, PMCID: PMC2843718HTML PDF
  • Gandy S, Simon AJ, Steele BA, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker W, Abel T, Schmeidler J, Ehrlich ME. Days-to-criterion as an indicator of toxicity associated with human Alzheimer’s amyloid-beta oligomers. Ann Neurol 2010;68(2):220-230. PMID: 20641005, PMCID: PMC3094694HTML PDF
  • Kaur G, Mohan P, Pawlik M, DeRosa S, Fajiculay J, Che S, Grubb A, Ginsberg SD, Nixon RA, Levy E. Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy. Am J Pathol 2010; 177(5):2256-2267. PMID: 20889561, PMCID: PMC2966785HTML PDF
  • Ghidoni R, Benussi L, Glionna M, Desenzani S, Albertini V, Levy E, Emanuele E, Binetti G. Plasma cystatin C and risk of developing Alzheimer’s Disease in subjects with mild cognitive impairment. J Alz Dis 2010;22(3):985-991. PMID: 20858959 Click for abstract
  • Yang D-S, Stavrides P, Mohan P, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Houseweart MK, Pawlik M, Peterhoff CM, Yang AJ, Myers RM, Wilson DA, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain 2010; 134(Pt 1):258-277. PMID: 21186265, PMCID: PMC3009842HTML  PDF
  • Wesson DW, Borkowski AH, Landreth GE, Nixon RA, Levy E, Wilson DA. Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer’s β-amyloidosis mouse model. J Neurosci 2011; 31(44):15962-15971. PMID: 22049439 PMCID: PMC3417321 HTMLPDF
  • Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM. Immunization targeting a minor plaque constituent clears beta-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiol Aging, 2013, 34(1):137-45 PMID: 22608241 PMCID:PMC3426627 Click for abstract PDF
  • Perez-Gonzalez R, Gauthier SA, Kumar A, Levy E. The exosome-secretory pathway transports amyloid precursor protein carboxyl terminal fragments from the cell into the brain extracellular space. J Biol Chem, 2012, 287(51):43108-15. PMID:23129776 PMCID: PMC3522305 Click for abstract PDF
  • Choi JH, Kaur G, Mazzella MJ, Morales-Corraliza J,Levy E, Mathews PM. Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice. J Alzheimers Dis, 2013;34(3):691-700. PMID:23254640 PMCID:PMC3616896 Click for abstract PDF
  • Kaur G, Sharma A, Xu W, Gerum S, Alldred MJ, Subbanna S, Basavarajappa BS, Pawlik M, Ohno M, Ginsberg SD, Wilson DA, Guilfoyle DN, Levy E. Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down's syndrome. Neurobiol Disease, 2014;34(15):5099-106. PMCID: PMC3983795 Click for abstract PDF
  • Xu W, Lopez-Guzman M, Schoen C, Fitzgerald S, Lauer SL, Nixon RA, Levy E, Wilson D. Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer’s disease. PLoS ONE, 2014; 9(9):e106431. PMCID:PMC4152226 Click for abstract PDF
  • Xu W, Fitzgerald S, Nixon RA, Levy E, Wilson D. Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease. Exp Neurol, 2014;264C82-91. PMCID:PMC4324092 Click for abstract PDF
  • Xu W, Lopez-Guzman M, Schoen C, Fitzgerald S, Lauer SL, Nixon RA, Levy E, Wilson DA. Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer’s disease. PLoS One. 2014;9(9):e106431. PMID; 25181487
  • Yelamanchili SV, Glamberty B, Rennard D, Morsey B, Levy E, Fox HS. MiR-21 in extracellular vesicles leads to neurotoxicity via TLR7 signaling in SIV neurological disease. PLOS Pathogens. 2015;11(7):e1005032. PMCID:PMC4496044 Click for abstract PDF
  • Xu W, Fitzgerald S, Nixon RA, Levy E, Wilson DA. Early hyperactivity in lateral entorhinal cortex is associated with accumulation of AbPP metabolites in the Tg2576 mouse model of Alzheimer’s disease. Exp Neurol. 2015;264:82-91. PMID: 25500142
  • Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA. Partial BACE1 reduction in a Down Syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: Role of APP-CTF. Neurobiol Aging, 2016;39:90-98. PMCID:PMC4773919 Click for abstract PDF
  • Mathews PM, Levy E. Cystatin C in aging and in Alzheimer’s disease. Ageing Res Rev. 2016;38-50. PMID: 27333827
  • Li W, Sultana N, Siraj N, Ward LJ, Pawlik M, Jovinge S, Bengtsson E, Yuan X-M. Autophagy dysfunction and regulatory cystatin C in cell death of atherosclerosis. J Cell Mol Med, 2016;20(9):1664-1672. PMID: 27079462Click for abstract PDF
  • Peng KY, Mathews PM, Levy E, Wilson DA. Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments. Neuroscience, 2017;343:364-371. PMCID 28003161Click for abstract PDF
  • Perez-Gonzalez R, Gautier SA, Kumar A, Saito M, Saito M, Levy E. A method for isolation and characterization of exosomes from brain extracellular space. Methods Mol Bio, 2017;1545:139-151. PMID: 27943212 Click for abstract
  • Kaur G, Pawlik M, Gandy S, Ehrlich ME, Smiley J, Levy E. Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein. Mol Psychiatry, 2017;22(7):981-989 PMCID:PMC5405008 Click for abstract PDF
  • Gauthier GA, Perez-Gonzalez R, Sharma A, Huang F-K, Alldred MJ, Pawlik M, Kaur G, Ginsberg SD, Neubert TA, Levy E. Enhanced exosome secretion in Down Syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities. Acta Neuropathol Commun. 2017;5(1):65 PMCID:PMC5576289 Click for abstract PDF
  • Nuriel T, Peng KY, Ashok A, Dillman AA, Figuerora H, Levy H, Cookson ME, Mathews PM and Duff KE. Endosomal-lysosomal pathway dysregulation by APOE4 expression in vivo. Frontiers in Neuroscience. 2017,11;702:1-12 PMID:29311783 Click for abstract PDF
  • East BS, Fleming G, Peng K, Olofsson JK, Levy E, Mathews PM, Wilson DA. Human Apolipoprotein E Genotype Differentially Affects Olfactory Behavior and Sensory Physiology in Mice. Neuroscience 2018, 380:103-110 PMID:29678753 Click for abstract PDF
  • Yelamanchili SV, Lamberty BG, Rennard DA, Morsey BM, Hochfelder CG, Meays BM, Levy E, Fox HS. Correction: MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease. PLOS Pathog. 2018 14(5) PMID: 29758080 Click for abstract PDF
  • Kaur G, Gautier SA, Pawlik M, Singh AB, Cosby B, Mohan PV, Smiley J, Levy E. Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of Down syndrome. Neurobiology of Disease 2018 120:165-173 NIHMS 1507331
  • Peng KY, Peez-Gonzalez R, Alldred MJ, Goulbourne CN, Corraliza JM, Saito M, Saito M, Saito M, Ginsberg SD, Mathews PM, Levy E. Apolipoprotein E4 compromises brain exosome production. Brain 2018 [Epub ahead of print]
  • Pacheco-Quinto J, Clausen D, Perez-Gonzalez R, Peng H, Meszaros A, Eckman CB, Levy E, Eckman EA. Intracellular metalloprotease activity controls intraneuronal AB aggregation and limits secretion of AB via exosomes. FASEB J. 2018 [Epub ahead of print]

Review, Books and Book Chapters

  • Hochman J, Levy E.  Growth regulation in S49 mouse lymphoma: Involvement of cyclic AMP and substrate adhesiveness. In: Bolis L, Verna R, Frati, L, eds. Peptide Hormones, Biomembranes and Cell Growth. New York: Plenum Press, 1984;155-167. [abstract not available]
  • Frangione B, Haltia M, Levy E, Ghiso J, Kiuru S, Prelli F, Wisniewski T.  Familial amyloidosis - Finnish type - and its relationship to Lewy bodies. In: Parkinson's and diffuse Lewy body diseases. Proceedings of the XIth International Congress of Neuropathology, Kyoto, 1990;150-156. [abstract not available]
  • Haltia M, Ghiso J, Prelli F, Levy E, Gallo G, Kiuru S, Somer H, Palo J, Frangione B.  Polymerization of gelsolin variant fragment in tissue causes familial amyloidosis, Finnish type (FAF). In: Natvig JB, Forre O, Husby G, Husebekk A, Skogen B, Sletten K, Westermark P, eds. Amyloid and Amyloidosis. VIth International Symposium on Amyloidosis. Dordrecht: Kluwer Academic Publishers, 1990;409-413. [abstract not available]
  • Levy E, Frangione B.  Familial Alzheimer's disease. Current Biology, 1991;1:312-314. PMID: 15336108 [abstract not available]
  • Frangione B, Haltia M, Levy E, Ghiso J, Kiuru S, Prelli F.  Co-occurrence of two amyloid proteins in a patient with familial amyloidosis, Finnish type. In: Iqbal K, McLachlan DRC, Winblad B, Wisniewski HM, eds. Alzheimer's disease: Basic mechanisms, diagnosis and therapeutic strategies. Chichester, England: John Wiley and Sons, 1991;255-264. [abstract not available]
  • Frangione B, Levy E.  Hereditary cerebral hemorrhage with amyloidosis and Alzheimer's disease. In: Ishii T, Allsop D, Selkoe DJ, eds, Frontiers of Alzheimer research. Amsterdam, The Netherlands: Elsevier Science Publishers, 1991;163-169. [abstract not available]
  • Levy E, Sastre M, Turner RS.  X11 modulation of b-amyloid precursor protein cellular stabilization and reduction of amyloid b-protein secretion. In: Iqbal K, Swaab DF, Winblad B, Wisniewski HM, eds, Alzheimer's disease and related disorders. Chichester, England: John Wiley and Sons, 1999;397-404. [abstract not available]
  • Jung S, Levy E.  Murine cerebrovascular cells as a cell culture model for cerebral amyloid angiopathy. Isolation of smooth muscle and endothelial cells from mouse brain. In: Sigurdsson EM, ed, Methods in Molecular Biology, vol. 299: Amyloid Proteins: Methods and Protocols. Totowa, NJ: Humana Press Inc., 2005;211-220. [abstract not available]
  • Prelli F, Pawlik M, Frangione B, Levy E.  Purification of human wild type or variant cystatin C from conditioned media of transfected cells. In: Sigurdsson EM, ed, Methods in Molecular Biology, vol. 299: Amyloid Proteins: Methods and Protocols. Totowa, NJ: Humana Press Inc., 2005;221-226. [abstract not available]
  • Tizon B, Levy E.  Protease inhibitors and their involvement in neurological disorders. In: Lajtha A, ed, Handbook of Neurochemistry and Molecular Neurobiology, 3rd Edition, vol. 7 New York, NY: Springer Publishers, 2006;591-624. [abstract not available]
  • Levy E, Prelli F, Frangione B.  Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant. J Alzheimers Dis. 2006;9(3 Suppl):329-39. PMID: 16914871 Click for abstract
  • Levy E, Jaskolski M, Grubb A.  The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal models. Brain Pathology 2006;16:60-70. PMID: 16612983 Click for abstract
  • Levy E.  Cystatin C: a potential target for Alzheimer’s treatment. Exp Rev Neurotherapeutics. 2008;8(5):687-689. PMID: 18457524 HTML PDF
  • Tizon B, Levy E. Cystatin C in Alzheimer’s disease. Fondation IPSEN. 2008. [abstract not available]
  • Gauthier S, Kaur G, Mi W, Tizon B, Levy E. Protective mechanisms by cystatin C in neurodegenerative diseases. In: Special Issue title: "Late onset neurodegenerative diseases: current advances and new hypotheses". Siamak Tabibzadeh, Editor-in-Chief. Front Biosci (Schol Ed). 2011 Jan 1;3:541-554. [abstract not available]
  • Gauthier SA, Sahoo S, Jung S, Levy E. Murine cerebrovascular cells as a cell culture model for cerebral amyloid angiopathy. Isolation of smooth muscle and endothelial cells from mouse brain. In: Sigurdsson EM, ed, Methods in Molecular Biology, vol. 849 : Amyloid Proteins: Methods and Protocols. Totowa, NJ: Humana Press Inc., 261-274, 2012. ISBN-13: 978-1617795503 [abstract not available]
  • Gauthier SA, Tizon B, Sahoo S, Levy E. In vitro assays measuring protection by proteins such as cystatin C of primary cortical neuronal and smooth muscle cells. In: Sigurdsson EM, ed, Methods in Molecular Biology, vol. 849: Amyloid Proteins: Methods and Protocols. Totowa, NJ: Humana Press Inc., 275-287, 2012. ISBN-13: 978-1617795503 [abstract not available]
  • Wesson DW, Nixon RA, Levy E, Wilson DA. Mechanisms of neural and behavioral dysfunction in Alzheimer's Disease. Mol Neurobiol. 2011; 43(3):163-79. PMID: 21424679, PMCID: PMC3090690 HTML PDF
  • Yang D-S, Stavrides P, Mohan P, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Myers RM, Wilson DA, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer's disease by enhancing lysosomal proteolysis. Autophagy, 2011; 7(7):788-9. PMID: 21464620 HTML PDF
  • Kaur G, Levy E. Cystatin C in Alzheimer's disease. Front Mol Neurosci, 2012; 5:79. PMID: 22783166 PMCID: PMC3390601 Click for abstract PDF
  • Kaur G, Sharma A, Xu W, Gerum S, Alldred M, Subbanna S, Basavarajappa BS, Pawlik M, Ohno M, Ginsberg SD, Wilson DA, Guilfoyle DN, Levy E. Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down’s syndrome. J Neurosc 2014;34(15):5099-5106. PMID: 24719089
  • Sandler I, Zigdon N, Levy E, Aharoni A. The functional importance of co-evolving residues in proteins. Cell Mol Life Sci, 2014; 71(4):673-82. Click for abstract
  • Pérez-González R, Gauthier SA, Kumar A, Saito M, Saito M, Levy E. A method for isolation and characterization of exosomes from brain extracellular space. Methods Mol Biol, 2017;1545:139-151. PMID: 27943212
  • Levy E. Exosomes in the diseased brain: first insights from in vivo studies. Front Neurosci, 2017,11;142:1-9 PMCID:PMC5362612 Click for abstract PDF

[last updated 02.25.19]