Publications for Paul M. Mathews, PhD

Requests for papers can be made by emailing Paul Mathews.

Publications

  1. Mathews PM, Martinie JB, Fambrough DM (1992) The pathway and targeting signal for delivery of the integral membrane glycoprotein LEP100 to lysosomes. Journal of Cell Biology. 118:1027-1040. HTML PDF
  2. Geering K, Jaunin P, Jaisser F, Merillat A-M, Horisberger J-D, Mathews PM, Lemas V, Fambrough DM, Rossier BC (1993) Mutation of a conserved proline residue in the b-subunit ectodomain prevents Na,K-ATPase oligomerization. American Journal of Physiology: Cell Physiology. 265:C1169-C1174. Click for abstract
  3. Beguin P, Beggah AT, Chibalin AV, Burgener-Kairuz P, Jaisser F, Mathews PM, Rossier BC, Cotecchia S, Geering K (1994) Phosphorylation of the Na,K-ATPase α-subunit by protein kinase A and C in vitro and in intact cells: identification of a novel motif for PKC-mediated phosphorylation. Journal of Biological Chemistry. 269:24437-24445. Click for abstract
  4. Modyanov NN, Mathews PM, Grishin AV, Beguin P, Beggah AT, Rossier BC, Horisberger J-D, Geering K (1995) Human ATPAL1 gene encodes a ouabain-sensitive H,K-ATPase. American Journal of Physiology: Cell Physiology. 363:C992-C997. Click for abstract
  5. Mathews PM, Claeys D, Geering K, Jaisser F, Horisberger J-D, Kraehenbuhl J-P, Rossier BC (1995) Primary sequence and functional expression of Xenopus and murine gastric H,K-ATPase a-subunit. American Journal of Physiology: Cell Physiology. 363:C1207-C1214. Click for abstract
  6. Beggah AT, Mathews PM, Beguin P, Geering K (1996) Degradation and endoplasmic reticulum retention of unassembled α- and β-subunits of Na,K-ATPase correlate with interaction of BiP. Journal of Biological Chemistry. 271:20895-20902. HTML PDF
  7. Capell A, Saffrich R, Olivo J-C, Meyn L, Walter J, Grunberg J, Mathews P, Nixon R, Dotti C, Haass C (1997) Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. Journal of Neurochemistry. 69:2432-2440. Click for abstract
  8. Chen PX, Mathews PM, Good PJ, Rossier BC, Geering K (1998). Unusual degradation of Aβ subunits of Xenopus gastric H-K-ATPase. American Journal of Physiology. 275:C139-145. HTML PDF
  9. Levesque L, Annaert W, Creassaerts K, Mathews P, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE (1999) Developmental expression of wild-type and mutant presenilin 1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine. 5:542-554. HTMLPDF
  10. Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Dole K, Lippa CF, Bird TD, Knochlin D, Walter J, Haass C, Lévesque L, Fraser PE, Andreadis A, Nixon RA (2000) Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine. 6:878-891. HTML PDF
  11. Singleton AB, Hall R, Ballard CG, Perry RH, Xuereb JH, Rubinsztein D, Tysoe C, Mathews P, Cordell B, Samir KS, De Jonghe C, Cruts M, van Broeckhoven C, Morris CM. (2000) Pathology of early onset Alzheimer’s disease cases bearing the Thr113-114ins presenilin-1 mutation. Brain. 12:2467-2474. HTML PDF
  12. Nixon RA, Cataldo AM, Mathews PM. (2000) The endosomal-lysosomal system of neurons in Alzheimer’s disease pathogenesis: a review. Neurochemical Research, 25:1161-1172. [review] Click for abstract
  13. Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D. (2000) Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer’s disease. Nature. 408:979-982. Click for abstract
  14. Nixon RA, Mathews PM, Cataldo AM. (2001) The Neuronal Endosomal-Lysosomal System in Alzheimer’s Disease. Journal of Alzheimer’s Disease, 3:97-107. [review] Click for abstract
  15. Rozmahel R, Huang J, Chen F, Liang Y, Nguyen YV, Ikeda M, Levesque G, Yu G, Nishimura M, Mathews P, Schmidt SD, Mercken M, Bergeron C, Westaway D, St George-Hyslop P (2002) Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP. Neurobiology of Aging. 23:187-194. Click for abstract
  16. Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. (2002) Alzheimer’s disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Aβ secretion: role for altered lysosomal hydrolase distribution in β-amyloidogenesis. Journal of Biological Chemistry. 277:5299-5307. HTML PDF
  17. Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramadhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HTJ, St George-Hyslop P, Fraser PE. (2002) Mature glycosylation and trafficking of nicastrin modulates its binding to presenilins. Journal of Biological Chemistry 277:28135-28142. HTML PDF
  18. Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA. (2002) Calpain activity regulates the cell surface distribution of amyloid precursor protein: inhibition of calpains enhances endosomal generation of β-cleaved C-terminal APP fragments. Journal of Biological Chemistry. 277: 36415-36424. HTML PDF
  19. Rozmahel R, Mount HTJ, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song Y-Q, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, Fraser P, Westaway D, St George-Hyslop P. (2002) Alleles at the nicastrin locus modify presenilin 1-deficiency phenotype. Proc. Natl. Acad. Sci. USA. 99:14452-14457. HTML PDF
  20. Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews PM, Jucker M. (2002) Cerebral hemorrhage after passive anti-Aβ immunotherapy. Science, 298:1379. PMID: 12434053 [No abstract available]
  21. Meyer-Luehmann M, Stalder M, Herzig MC, Kaeser SA, Kohler E, Pfeifer M, Boncristiano S, Mathews PM, Mercken M, Abramowski D, Staufenbiel M, Jucker M. (2003) Extracellular amyloid formation and associated pathology in neural grafts. Nature Neuroscience, 6:370-377. Click for abstract
  22. Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. (2003) Presenilin redistribution associated with aberrant cholesterol transport enhances b-amyloid production in vivo. Journal of Neuroscience, 23:5645-5649. HTMLPDF
  23. Mathews PM, Nixon RA. (2003) Setback for Alzheimer’s vaccine: lessons learned. Neurology, 61:7-8. [No abstract available]
  24. Mathews PM, Grbovic OM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. (2003) Rab5-stimulated up-regulation of the endocytic pathway increases intracellular β-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Aβ production. Journal of Biological Chemistry, 278:31261-31268. HTML PDF
  25. Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti M, Cox D, Mathews PM, Nixon RA, Carlson GA, St George-Hyslop P, Westaway D. (2003) In vivo reduction of amyloid-β by a mutant copper transporter. Proc. Natl. Acad. Sci. USA. 100:14193-14198. HTML PDF
  26. Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD, Nixon RA, Levy E. (2004) Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid β peptide. Journal of Molecular Neuroscience, 22:13-18. Click for abstract
  27. Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. (2004) Co-expressed presenilin 1 NTF and CTF form functional γ-secretase complexes in cells devoid of full-length protein. Journal of Neurochemistry, 89:44-53. Click for abstract
  28. Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O. (2004) Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Annals of Neurology, 55:801-814. Click for abstract
  29. Pastorino L, Ikin AF, Lambrianou S, Vacaresse N, Revelli JP, Platt K, Paganetti P, Mathews PM, Harroch S, Buxbaum JD. (2004) BACE (β-secretase) modulates the processing of APLP2 in vivo. Molecular and Cellular Neuroscience, 25:642-649. Click for abstract
  30. Verdile G, Groth D, Mathews PM, St George-Hyslop P, Fraser PE, Ramabhadran TV, Kwok JBJ, Schofield PR, Carter T, Gandy S, Martins RN. (2004) Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid β-like protein in Sf9 cells. Molecular Psychiatry, 9:594-602. Click for abstract
  31. Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Näslund J. (2004) Functional domains in presenilin 1: the Tyr-288 residue controls γ-secretase activity and endoproteolysis. Journal of Biological Chemistry, 279:23925-23932. HTML PDF
  32. Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V, Schmidt SD, Nixon RA, Frangione B, Levy E. (2004) Binding of cystatin C to Alzheimer’s amyloid β inhibits in vitro amyloid fibril formation. Neurobiology of Aging, 25:1033-1043. Click for abstract
  33. Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, Laska E, Ehrlich ME, Walker LC, Mathews PM, Gandy S. (2004) Aging, gender and APOE isotype modulate metabolism of Alzheimer's Aβ peptides and F2-isoprostanes in the absence of detectable amyloid deposits. Journal of Neurochemistry, 90:1011-1018. Click for abstract
  34. Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman MLC, Staufenbiel M, Mathews PM, Jucker M. (2004) Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nature Neuroscience, 7:954-960 Click for abstract
  35. Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA. (2004) Presenilin mutations in familial Alzheimer’s disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuro Exp Neurol, 63:821-830. Click for abstract
  36. Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T. (2004) A synthetic peptide blocking the apolipoprotein E/β-amyloid binding mitigates β-amyloid toxicity and fibril formation in vitro and reduces β-amyloid plaques in transgenic mice. Am J Pathol, 165:937-948. HTML PDF
  37. Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai T, Katayama T, Schmidt SD, Mathews PM, Schmitt-Ulms G, Fraser PE, St George-Hyslop P. (2004) Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. J Biol Chem, 279:46455-46463. HTML PDF
  38. Lacombe P, Mathews PM, Schmidt SD, Breidert T, Heneka MT, Landreth G, Feinstein DL, Galea E. (2004) Effect of anti-inflammatory agents on transforming growth factor β overexpressing mouse brains: a model revised. J Neuroinflammation, 1:11. HTML PDF
  39. Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Naslund J, Mathews PM, Cataldo AM, Nixon RA. (2005) Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer’s disease. J Cell Biol, 171:87-98. HTML PDF
  40. Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu U, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. (2005) Dissociated phenotypes in presenilin transgenic mice define functionally distinct γ-secretases. Proc. Natl. Acad. Sci. USA. 102:8972-8977. HTML PDF
  41. Schmidt SD, Jiang Y, Nixon RA, Mathews PM. (2005) Tissue processing prior to protein analysis and amyloid-β quantitation. Methods in Molecular Biology: Amyloid Proteins, Methods and Protocols (Sigurdsson EM, editor), The Humana Press, Inc., Totowa, NJ, 299:267-78.
  42. Schmidt SD, Nixon RA, Mathews PM. (2005) ELISA method for measurement of amyloid-b levels. Methods in Molecular Biology: Amyloid Proteins, Methods and Protocols (Sigurdsson EM, editor), The Humana Press, Inc., Totowa, NJ, 299:279-97.
  43. Tate BA, Mathews PM. (2006) Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment. Sci Aging Knowledge Environ. 10:re2. [review] Click for abstract
  44. Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jaggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Holscher C, Mathews PM, Jucker M. (2006) Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Reports. 7:940-946. HTML PDF
  45. Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J-M, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M. (2006) Exogenous induction of cerebral β-amyloidogenesis is governed by agent and host. Science. 313(5794):1781-1784. Click for abstract
  46. Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T. (2006) Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology. The Journal of Clinical Investigation, 116 (11): 3060-3069. HTML PDF
  47. Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima-Ando K, Iijima K, Mathews PM, Itohara S, Gandy S, Suzuki T. (2006) Physiological Mouse Brain Aβ Levels are not related to the Phosphorylation State of Threonine-668 of Alzheimer’s APP. PloS ONE.2006; 1(1): e51. HTML PDF
  48. Gandy S, Zhang Y, Ikin A, Schmidt SD, Levy E, Sheffield R, Nixon RA, Liao F, Mathews PM, Xu H, Ehrlich ME. (2007) Alzheimer’s Presenilin 1 Modulates Sorting of APP and its Carboxyl-Terminal Fragments in Cerebral Neurons in vivo. Journal of Neurochemistry,  102: 619-626. Erratum in: J Neurochem. 2007 Nov; 103(3)1272. Bogush, Alexey [added], PMID: 17630980. Click for abstract
  49. Dorval V, Mazzella, MJ, Mathews PM, Hay RT, Fraser PE (2007) Modulation of Aβ Generation by Small Ubiquitin-like Modifiers Does Not Require Conjugation to Target Proteins. Biochemical Journal, 404(2):309-16. PMID:17346237. HTML PDF
  50. Elder, GA, Cho JY, English DF, Franciosi S, Schmeidler J, Gama Sosa MA, De Gasperi R, Fisher EA, Mathews PM, Haroutunian V, Buxbaum JD. (2007) Elevated plasma cholesterol does not affect brain Aβ in mice lacking the low-density lipoprotein receptor. Journal of Neurochemistry 102(4): 1220-1231, PMID: 17472705. Click for abstract
  51. Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. (2007) Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models. Nat Genet. 2007 Dec;39(12):1440-2. PMID: 18026100. Click for abstract
  52. Bai,Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, Bagshaw R, Mathews PM, Fraser PE, Westaway D, St. George-Hyslop P, Schmitt-Ulms G. (2008) The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics 7.1: 15-34, PMID: 17934213. HTML PDF
  53. Cataldo AM, Mathews PM, Boiteau AB, Hassinger LC, Peterhoff CM, Jiang Y, Mullaney K, Neve RL, Gruenberg J, Nixon RA. (2008) Down syndrome fibroblast model of Alzheimer-related endosome pathology accelerated endocytosis promotes late endocytic defects. Am J Pathol, 173(2): 370-84. PMID: 18535180, PMCID: PMC2475775. HTML PDF
  54. Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. (2008) Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest, 118(8): 2796-807. PMCID: PMC2441853. HTML PDF
  55. Mi W, Jung SS, Yu H, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E. (2009) Complexes of amyloid-β and cystatin C in the human central nervous system. Journal of Alzheimer's Disease, 18(2): 273-80. PMCID: PMC2792995. HTML PDF
  56. Choi JHK, Berger JD, Mazzella MJ, Morales-Corraliza J, Nixon RA, Ginsberg SD, Levy E, Mathews PM. (2009) Age-dependent dysregulation of brain APP in the Ts65Dn Down syndrome mouse model. Journal of Neurochemistry, 110(6): 1818-1827, PMC2744432. HTML PDF
  57. Morales-Corraliza J, Diaz NS, Berger JD, Mazzella MJ, Choi JHK, Levy E, Matsuoka Y, Planel E, Mathews PM. (2009) In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the β-amyloid depositing mice. PLOS One, 4(9): e 7134. PMID:1977116. HTML PDF
  58. Bernardo A, Harrison FE, McCord M, Zhao J, Bruchey A, Davies SS, Jackson Roberts L 2nd, Mathews PM, Matsuoka Y, Ariga T, Yu RK, Thompson R, McDonald MP. (2009) Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice. Neurobiology of Aging, 30(11):1777-91, PMID: 18258340. Click for abstract
  59. Grathwohl SA, Kalin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M. (2009) Formation and maintenance of β-amyloid plaques in Alzheimer’s disease in the absence of microglia.  Nature Neuroscience, 12: 1358-1360, PMID: 19838177, NIHMSID: 172970. Click for abstract
  60. Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, and Nixon RA (2010) Alzheimer’s-related endosome dysfunction in Down syndrome is Aβ-independent but requires APP and is reversed by BACE-1 inhibition. Proc. Nat. Acad. Sci., 107(4):1630-5. PMCID: PMC2824382 HTML PDF
  61. Coomaraswamy J, Kilger E, Wolfing H, Schafer C, Kaeser SA, Wegenast-Braun BM, Hefendhl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M. (2010) Modling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer’s disease. Proc. Natl. Acad. Sci. U. S. A., 107(17):7969-74. PMID: 20385796 HTML PDF
  62. Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, Mathews PM, Saftig P, Sandhoff K, Walter J. (2011) Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Aβ generation. J Neurosci, 31(5):1837-49. HTML PDF
  63. Restituito S, Khatri L, Ninan I, Mathews PM, Liu X, Weinberg RJ, Ziff EB. (2011) Synaptic autoregulation by metalloproteases and γ-secretase. J Neurosci, 31(34):12083-93. Erratum in: J Neurosci. 31(38):13695. Click for abstract
  64. Yang DS, Stavrides P, Mohan PS, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. (2011) Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy 7(7):788-9. HTML PDF
  65. Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA, Mathews PM. (2011) Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiol Aging, 2012 Jun;33(6):1125.e9-18. PMID: 22206846, PMCID: PMC3318946 Click for abstract PDF
  66. Delay C, Calon F, Mathews P, Hebert SS. (2011) Alzheimer-specific variants in the 3'UTR of amyloid precursor protein affect microRNA function. Mol Neurodegen. 2011 Oct 7, 6:70. PMCID: PMC3195754 HTML PDF
  67. Schmidt SD, Nixon RA, Mathews PM. (2012) Tissue processing prior to analysis of Alzheimer's disease-associated proteins and metabolites, including Aβ. Amyloid Proteins: Methods and Protocols, Methods in Molecular Biology, Vol. 849 (Ed. Sigurdsson, EM), Springer Science+Business Media, LLC, in press. [No abstract available]
  68. Schmidt SD, Mazzella MJ, Nixon RA, Mathews PM. (2012) Measurement by enzyme-linked immunosorbent assay. Amyloid Proteins: Methods and Protocols, Methods in Molecular Biology, Vol. 849 (Ed. Sigurdsson, EM), Springer Science+Business Media, LLC, in press. [No abstract available]
  69. Schmidt SD, Mazzella MJ, Nixon RA, Mathews PM. (2012) Abeta measurement by enzyme-linked immunosorbent assay. Methods Mol Biol 849:507-27. Click for abstract
  70. Schmidt SD, Nixon RA, Mathews PM. (2012) Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Abeta. Methods Mol Biol 849:493-506. Click for abstract
  71. Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM. Immunization targeting a minor plaque constituent clears beta-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiol Aging, 2013, 34(1):137-45 PMID: 22608241 PMCID:PMC3426627 Click for abstract PDF
  72. Papon MA, El Khoury NB, Marcouiller F, Julien C, Morin F, Bretteville A, Petry FR, Gaudreau S, Amrani A, Mathews PM, Hébert SS, Planel E. Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of τ Protein Following Onset of Diabetes in NOD Mice. Diabetes. 2013 Feb;62(2):609-17. PMID:22961084 PMCID:PMC3554372 Click for abstract PDF

     
  73. Wesson DW, Morales-Corraliza J, Mazzella MJ, Wilson DA, Mathews PM. (2013) Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model. Behav Brain Res. 237:96-102. PMID:23000537 PMCID:PMC3500395 Click for abstract PDF
  74. Jeon AH, Böhm C, Chen F, Huo H, Ruan X, Ren CH, Ho K, Qamar S, Mathews PM, Fraser PE, Mount HT, St George-Hyslop P, Schmitt-Ulms G. Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. J Biol Chem. 2013 May 24;288(21):15352-66. doi: 10.1074/jbc.M112.441840. PMID: 23589300 PMCID: PMC3663554 Click for abstract PDF
  75. Duffy AM, Morales-Corraliza J, Bermudez-Hernandez KM, Schaner MJ, Magagna-Poveda A, Mathews PM, Scharfman HE. Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age. 2014 [Epub ahead of print] PMID:25109765 Click for abstract PDF
  76. Schafer MJ, Alldred MJ, Lee SH, Valhoun ME, Petkova E, Mathews PM, Ginsberg SD. Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice. Neurobiology of aging 2015; 36(3):1293-302 PMID:25556162 PMCID:PMCID4346433 Click for abstract PDF
  77. Mahler J, Morales-Corraliza J, Stolz J, Skodras A, Radde R, Duma CC, Eisele YS, Mazzella MJ, Wong H, Klunk WE, Nilsson KPR, Staufenbiel M, Mathews PM, Jucker M, Wegenast-Braun BM. Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPS1 transgenic mice. Neurobiology of aging. 2016;39:90-8 PMID:25911278 PMCID:PMC:4457564 Click for abstract PDF
  78. Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA. Partial BACE1 reduction in a Down synfrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiology of aging 2016;39:90-8 PMID: 26923405 PMCID:PMCID: PMC4773919 Click for abstract PDF
  79. Morales-Coraliza J, Wong H, Mazzella MJ, Che S, Lee SH, Petkova E, Wagner JD, Hemby SE, Ginsberg SD, Mathews PM. Brain-wide insulin resistance, Tau Phosphorylation Changes and Hippocampal Neprilysin and Amyloid-β alterations in a monkey model of Type 1 Diabetes. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2016; 36(15):4248-58 PMID: 27076423 PMCID: PMC4829649 Click for abstract PDF
  80. Nuriel T, Peng KY, Ashok A, Dillman AA, Figuerora H, Levy H, Cookson ME, Mathews PM and Duff KE. Endosomal-lysosomal pathway dysregulation by APOE4 expression in vivo. Frontiers in Neuroscience. 2017,11:702:1-12 Click for abstract PDF

[last updated 2.8.18]