Publications for Ralph Nixon, MD, PhD

Requests for papers can be made by emailing Chitra Hindnavis .

Original Publications

  1. Bordi M, Darji S, Sato Y, Mellen M, Berg MJ, Kumar A, Jiang Y, Nixon RA. mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation and mitophagy. Cell Death&Disease 2019 10(8):563 doi: 10.1038/s41419-019-1752-5 PMID: 31332166 Click for abstract
  2. Jiang Y, Sato Y, Im E, Berg M, Bordi M, Darji S, Kumar A, Mohan PS, Bandyopadhyay U, Diaz A, Maria Cuervo A, Nixon RA. Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-BCTF (C99). Journal of Neuroscience 2019 doi: 10.1523/JNEUROSCI.0578-19.2019 PMID: 31043483 Click for abstract
  3. Lee JH, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA. Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo. Autophagy 2019 15(3):543-557 PMID: 30269645 Click for abstract PDF
  4. Yuan A, Veeranna, Sershen H, Basavarajappa BS, Smiley JF, Hashim A, Bleiwas C, Berg M, Guifoyle DN, Subbanna S, Darji S, Kumar A, Rao MV, Wilson DA, Julien JP, Javitt DC, Nixon RA. Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors. Translational Psychiatry 2018 8:167 doi:10.1038/s41398-018-0194-7 PMID: 30143609 Click for abstract PDF
  5. Yang DS, Stavrides P, Kumar A, Jiang Y, Mohan PS, Ohno M, Dobrenis K, Davidson CD, Saito M, Pawlik M, Huo C, Walkley SU, Nixon RA. Cyclodextrin has conflicting actions on autophagy flux in vivo brains of normal and Alzheimer model mice. Human Molecular Genetics 2017 26(5):843-859 PMID:28062666 Click for abstract PDF
  6. Rosa E, Mahendram S, Ke YD, Ittner LM, Ginsberg SD, Fahenstock M. Tau downregulated BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiology of Aging 2016 48:135-142 PMID:27676333 Click for abstract PDF
  7. Kim S, Sato Y, Mohan PS, Peterhof C, Pensalfini A, Rigoglioso A, Jiang Y, Nixon RA. Evidence that the rab5 effector APPL1 mediates APP-BCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease. Molecular Psychiatry, 2016 21(5):707-16 PMID:26194181 Click for abstract PDF
  8. Bordi M, Berg MJ, Mohan PS, Peterhoff CM, Alldred MJ, Che S, Ginsberg SD, Nixon RA. Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy, 2016 12(12):2467-2483 PMID:27813694 Click for abstract PDF
  9. Yuan A, Nixon RA. Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders. Brain Research Bulletin, 2016 126:(Pt3):334-346 PMID:27609296 Click for abstract PDF
  10. Rao MV, Campbell J, Palaniappan A, Kumar A, Nixon RA. Calpastain inhibits motor neuron death and increases survival of hSOD1(G93A) mice. Journal Neurochem, 2016, 137(2):253-65 PMID:26756888 Click for abstract PDF
  11. Xu W, Fitzgerald S, Nixon RA, Levy E, Wilson D. Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease. Exp Neurol, 2015, 264: 82-91Click for abstract PDF
  12. Yuan A, Sershen H, Veeranna SM, Basavarajappa BS, Kumar A, Hashin A, Berg M, Lee JH, Sato Y, Rao MV, Mohan PS, Dyakin V, Julien JP, Lee VM, Nixon RA. Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo. Mol Psychiatry, 2015, 22(8): 986-94. Click for abstract PDF
  13. Menzies FM, Garcia-Arencibia M, Imarisio S, O’Sullivan NC, Ricketts T, Kent BA, Rao MV, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O’Kane CJ, Lam W, Rubinsztein DC. Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity. Cell Death Diff, 2015, 22, 433-44. Click for abstract PDF
  14. Xue X, Wang L-R, Sato Y, Jiang Y, Berg M, Yang D-S, Nixon RA, Liang X-J. Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer’s disease. Nano Lett, 2014, 14(9):5110-7. PMC4160261 [Available 2015/8/12] PMID: 2511567 Click for abstract PDF
  15. Xu W, Lopez-Guzman M, Schoen C, Fitzgerald S, Lauer SL, Nixon RA, Levy E, Wilson D. Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer’s disease. PLoS ONE 2014, 9(9):e106431. PMCID:PMC4152226 Click for abstract PDF
  16. Yang D-S, Stavrides P, Saito M, Kumar A, Rodriguez-Navarro JA, Pawlik M, Huo C, Walkley SU, Saito M, Cuervo AM, Nixon RA. Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: Prevention by correcting lysosomal proteolytic deficits. Brain 2014, 137(Pt 12):3300-18. PMCID:PMC4240291 [Available on 2015/12/1] Click for abstract PDF
  17. Rao M, McBrayer MK, Campbell J, Kumar A, Hashim A, Sershen H, Stavrides PH, Ohno M, Hutton M, Nixon RA. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in Tau P301L mice. J Neurosci, 2014, 34(28):9222-34. PMC4087203 [Available 2015/1/9] Click for abstract PDF
  18. Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S. Overexpression of the Calpain-specific Inhibitor Calpastatin reduceshuman alpha-Synuclein Processing, Aggregation and Synaptic Impairment in[A30P]αSyntransgenic mice. Hum Mol Genet 2014, 23(15):3975-89. PMID: 24619358 PMC4110482 Click for abstract PDF
  19. Annunziata I, Patterson A, Helton D, Hu H, Moshiach S, Gomero E, Nixon RA d’Azzo A. Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis. Nature Comm, 2013, 4:2734. PMID: 24225533 PMCID: PMC4015463 Click for abstract PDF
  20. Yuan A, Kumar A, Sasaki T, Duff K, Nixon RA. Global axonal transport rates are unaltered in Htau mice in vivo. J Alzheimers Dis, 2013, 37(3):579-86. PMID: 23948900 PMC3819434 HTML
  21. Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA. Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci 2013, 37(12):1949-61. PMID:23773064 PMCID: PMC3694736 [Available on 2014/6/1] Click for abstract
  22. Subbanna S, Shivakumar M, Umapathy NS, Saito M, Mohan PS, Kumar A, Nixon RA, Verin AD, Psychoyos D, Basavarajappa BS. G9a-Mediated Histone Methylation Regulates Ethanol-Induced Neurodegeneration in the Neonatal Mouse Brain. Neurobiol Dis. 2013, 54:475-85. PMC3656439 [Available on 2014/6/1]PMID: 23396011 Click for abstract
  23. Rao MV, Yuan, A, Campbell J, Kumar S, Nixon RA. The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network. PLoS ONE, 2012, 7(9):e44320. PMID:2302852 HTML PDF
  24. Yuan A, Sasaki T, Kumar S, Peterhoff C, Rao MV, Liem RK, Julien J-P, Nixon RA. Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and PNS axons. J Neurosci, 2012, 32(25):8501-8. PMID: 22723690 PMCID: PMC3405552 HTML PDF
  25. Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA, Mathews PM. (2011) Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiol Aging, 2012 Jun;33(6):1125.e9-18. PMID: 22206846, PMCID: PMC3318946 Click for abstract PDF
  26. Morales-Corraliza J, Schmidt SD, Mazzella MJ, Berger JD, Wilson DA, Wesson DW, Jucker M, Levy E, Nixon RA, Mathews PM. Immunization targeting a minor plaque constituent clears beta-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model. Neurobiol Aging, 2013, 34(1):137-45 PMID: 22608241 PMCID:PMC3426627 Click for abstract PDF
  27. Wesson D, Borkowski AH, Landreth GE, Nixon RA, Levy E, Wilson D. Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model. J Neurosci, 2011, 31(44): 15962-71. PMCID: PMC3417321 HTMLPDF
  28. Ginsberg SD, Mufson EJ, Alldred MJ, Counts SE, Wuu J, Nixon RA, Che S. Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer’s disease. J Chem Neuroanat, 2011, 42(2):102-10. PMC3163754 HTMLPDF
  29. Rao MV, Mohan P, Kumar A, Yuan A, Montagna L, Campbell J, Veeranna, Espreafico EM, Julien JP, Nixon RA. The Myosin Va head domain binds to the neurofilament-L rod and modulates Endoplasmic reticulum (ER) content and distribution within axons. PLoS ONE, 2011; 6(2):e17087. PMC3040190 HTML PDF
  30. Wesson DW, Nixon RA, Levy E, Wilson DA. Mechanisms of neural and behavioral dysfunction in Alzheimer's disease. Mol Neurobiol, 2011; 43(3):163-79. PMC3090690 HTML PDF
  31. Lee SY, Sato Y, Nixon RA. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer’s-like axonal dystrophy. J Neurosci, 2011; 31(21):7817-30. PMCID: PMC3351137 HTMLPDF
  32. Yang DS, Stavrides P, Mohan P, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff PM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain 2011; 134(1):258-77. PMC300984 HTML PDF
  33. Rubinsztein D, Nixon RA. Rapamycin induces autophagic flux in neurons [Letter to the editor]. PNAS 2010; 107(49):E181. PMC3000262 HTML PDF
  34. Kaur G, Mohan P, Pawlik M, DeRosa S, Fajiculay J, Che S, Grubb A, Ginsberg SD, Nixon RA, Levy E. Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy. Am J Pathol 2010; 177(5):2256-67. PMC2966785 HTML PDF
  35. Ginsberg SD, Alldred M, Counts SE, Cataldo AM, Neve RL, Jiang Y, Wuu J, Chao MV, Mufson EJ, Nixon RA, Che S. Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer’s disease progression. Biol Psych 2010; 68:885-93. PMC2965820 HTMLPDF
  36. Ginsberg SD, Mufson EJ, Counts SE, Wuu J, Alldred MJ, Nixon RA, Che S. Regional selectivity of rab5 and rab7 protein up regulation in mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis 2010; 22(2):631-9. HTML PDF
  37. Rothenberg C, Srinivasan D, Mah L, Kaushik S, Peterhoff CM, Ugolino J, Fang S, Cuervo AM, Nixon RA, Monteiro MJ. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet 2010; 19(16): 3219-32. PMC2908472 HTML PDF
  38. Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vincente M, Massey AC, Sovak G, Uchiyama Y, Westway D, Cuervo AM, Nixon RA. Lysosomal proteolysis and autophagy require Presenilin 1 and are disrupted by Alzheimer’s related PS1 mutations. Cell, 2010, 14(7):1146-1158. PMID:20541250 PMCID: PMC3647462 Click for abstractPDF
  39. Dyakin VV, Chen Y, Branch CA, Veeranna, Yuan A, Rao M, Kumar A, Peterhoff C, Nixon RA. The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models. NeuroImage 2010; 51:1098-105. PMC2862816 HTML PDF
  40. Tizon B, Sahoo S, Yu H, Gauthier S, Kumar AR, Mohan P, Figliola M, Pawlik M, Grubb A, Uchiyama Y, Bandyopadhyay U, Cuervo AM, Nixon RA, Levy E. Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PLoS One 2010; 5:e9819. PMCID: PMC2843718HTML PDF
  41. Wesson DW, Levy E, Nixon RA, Wilson DA. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer’s disease mouse model. J Neurosci; 2010; 30:505-514. PMC2826174 HTML PDF
  42. Tizon B, Sahoo S, Yu H, Gauthier S, Kumar AR, Mohan P, Figliola M, Pawlik M, Grubb A, Uchiyama Y, Bandyopadhyay U, Cuervo AM, Nixon RA, Levy E. Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PLoS One 2010; 5:e9819. PMC2843718 HTML PDF
  43. Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA. Alzheimer’s-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Nat Acad Sci 2010; 107:1630-1635. PMC2824382 HTML PDF
  44. Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim T-W. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J 2010; 24(8): 2783-94. PMC2909280 HTML PDF
  45. Mi W, Jung SS, Yu WH, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E. Complexes of amyloid beta and cystatin C in human central nervous system. J Alzheimers Dis 2009; 18:273-80. PMC2792995 HTML PDF
  46. Choi J, Berger JD, Mazzella MJ, Morales-Corraliza J, Cataldo AM, Nixon RA, Ginsberg SD, Levy E, Mathews PM. Age-dependent dysregulation of brain APP in the Ts65Dn Down syndrome mouse model. J Neurochem 2009; 110:1818-1827. PMC2744432 HTML PDF
  47. Veeranna, Yang DS, Lee JH, Vinod KY, Stavrides P, Amin ND, Pant HC, Nixon RA. Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol Aging 2009; 32(11):2016-29. PMC2891331
  48. Yuan A, Sasaki T, Rao MV, Kumar A, Kanumuri V, Dunlop DS, Liem RK, Nixon RA. Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons. J Neurosci 2009; 29:11316-11329. PMC2788791 HTML PDF
  49. Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci 2008; 28:12798-12807. PMC2610528 HTML PDF
  50. Veeranna, Lee JH, Pareek TK, Jaffee H, Boland B, Vinod KY, Amin N, Kulkarni AB, Pant HC, Nixon RA. Neurofilament tail phosphorylation: Identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. J Neurochem 2008; 107:35-49. PMC2941900. HTML PDF
  51. Rao MV, Mohan PS, Peterhoff CM, Yang DS, Schmidt SD, Stavrides PH, Campbell J, Chen Y, Jiang Y, Paskevich PA, Cataldo AM, Haroutunian V, Nixon RA. Marked calpastatin (CAST) depletion in Alzheimer’s disease accelerates cytoskeleton disruption and neurodegeneration: Neuroprotection by CAST over-expression. J Neurosci 2008; 28:12241-54. PMC2819018 HTML PDF
  52. Yang DS, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M, Levy E, Cataldo AM, Nixon RA. Neuronal apoptosis and autophagy crosstalk in aging PS/APP mice, a model of Alzheimer’s disease. Am J Pathol 2008; 173:665-681. PMC2527090. HTML PDF
  53. Chen Y, Dyakin VV, Branch CA, Ardekani B, Yang D, Guilfoyle DN, Peterson J, Peterhoff C, Ginsberg SD, Cataldo AM, Nixon RA. In vivo MRI identifies specific cholinergic circuitry deficits in a mouse model of Down Syndrome. Neurobiol Aging 2008; 30:1453-65. PMC2771203 HTML PDF
  54. Cataldo AM, Mathews PM, Boiteau AB, Hassinger LC, Peterhoff CM, Gruenberg J, Neve RL, Nixon RA. Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. Am J Pathol 2008; 173:370-384. PMC2475775 HTML PDF
  55. Trinchese F, Fa M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest 2008; 118:2796-2807. PMC2441853. HTML PDF
  56. Azmitia EC and Nixon RA. Dystrophic serotonergic axons in neurodegenerative diseases. Brain Res. 2008; 1217C:185-194.
    PMC3405553 HTML PDF
  57. Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer’s disease. J Neurosci 2008; 28:6926-6937. PMC2676733 HTML PDF
  58. Yuan A, Kumar A, Peterhoff C, Duff K, Nixon RA. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci. 2008; 28:1682-1687. PMC2814454 HTML PDF
  59. Klionsky DJ, Abeliovich H, Agostinis P,…Nixon, RA… et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4:151-175 PMID: 18188003. HTML PDF
  60. Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Paul M. Mathews PM, Levy E. Cystatin C inhibits amyloid b deposition in Alzheimer’s disease mouse models. Nature Genet 2007; 39: 1440-1442. PMID: 18026100. Click for abstract
  61. Falangola MF, Dyakin VV, Lee SP, Bogart A, Babb JS, Duff K, Nixon R, Helpern JA. Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer’s disease. NMR Biomed 2007; 20:343-351. PMID: 17451178 Click for abstract
  62. Battaglia F, Wang HY, Ghilardi MF, Gashi E, Quartarone A, Friedman E, Nixon RA. Cortical plasticity in Alzheimer’s disease in humans and rodents. Biol Psychiatry 2007; 62(12):1405-12 PMID: 17651702. Click for abstract
  63. Gandy S, Zhang YW, Ikin A, Schmidt SD, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer’s presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. J Neurochem 2007; 102:619-626 PMID: 17630980. Click for abstract
  64. Yuan A, Rao MV, Sasaki T, Chen Y, Kumar A, Veeranna, Liem RK, Eyer J, Peterson AC, Julien JP, Nixon RA. Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. J Neurosci 2006; 26:10006-10019 PMID : 17005864. HTML PDF
  65. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb, BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 2006; 51:29-42 PMID:16815330. Click for abstract
  66. Liang J, Yin C, Doong H, Fang S, Peterhoff C, Nixon R, Monteiro MJ. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. J Cell Sci 2006; 119:4011-4024 PMID:16968747 HTMLPDF
  67. Yuan A, Nixon RA, Rao MV. Deleting the phosphorylated tail domain of the neurofilament heavy subunit does not alter neurofilament transport rate in vivo. Neurosci Lett 2006; 393:264-268. PMID:16266786 Click for abstract
  68. Falangola MF,Ardekani BA, Lee SP, Babb JS, Bogart A, Dyakin VV, Nixon R, Duff K, Helpern JA. Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology. J Neurosci Methods 2005; 144:91-97. PMID: 15848243 Click for abstract
  69. Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Naslund J, Mathews PM, Cataldo AM, Nixon RA. Macroautophagy – a novel amyloid-b (Ab) peptide-generating pathway activated in Alzheimer’s disease. J Cell Biology 2005; 171:87-98. PMC2171227 HTML PDF
  70. de Grey AD, Alvarez PJ, Brady RO, Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR. Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Res Rev 2005 4:315-338. PMID: 16040282 Click for abstract
  71. Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Eberling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Nat Acad Sci USA 2005; 102:8972-8977. PMC1149500 HTML PDF
  72. Falangola MF, Lee S-P, Nixon RA, Duff K, Helpern JA. Histological co-localization of iron in Ab plaques of PS/APP Transgenic Mice. Neurochem Res 2005; 30:201-205. PMID: 15895823 Click for abstract
  73. Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 2005; 64:113-122. PMID: 15751225
  74. Carter TL, Verdile Giuseppe, Groth D, Bogush A, Thomas S, Shen P, Fraser PE, Mathews P, Nixon RA, Ehrlich ME, Kwok JB, St. George-Hyslop P, Schofield P, Li Y, Yang A, Martins RN, Gandy S. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Dis Assoc Disord 2004; 18:261-263. PMID: 15592142
  75. Cataldo AM, Petanceska S, Terio NB, Peterhoff CM, Durham R, Mercken M, Mehta PD, Buxbaum J, Haroutunian V, Nixon RA. Ab localization in abnormal endosomes: association with earliest Ab elevation in AD and Down syndrome. Neurobiol Aging 2004; 25:1263-1272. PMID: 15465622 Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V, Schmidt SD, Nixon RA, Frangione B, and Levy E. Binding of cystatin C to Alzheimer’s amyloid-b inhibits in vitro amyloid fibril formation. Neurobiol Aging 2004 25:1033-1043. PMID: 15212828
  76. Yu WH, Kumar A, Peterhoff C, Shapiro Kulkane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA. Autophagic vacuoles are enriched in APP-secretase activities: Implications for Ab peptide over-production and localization in Alzheimer’s disease. Int J Biochem Cell Biol 2004; 36:2531-2540. PMID: 15325590
  77. Lee S-P, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of ß-Amyloid Plaques in a Transgenic Mouse Model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med 2004; 52:538-544. PMID: 15334572
  78. Cataldo AM, Peterhoff CM, Schmidt SD, Terio N, Duff K, Beard M, Mathews PM, Nixon RA. Presenilin mutations in familial Alzheimer’s disease and transgenic mouse models accelerate neuronal lysosomal pathology. JNEN 2004; 63:821-830. PMID:15330337
  79. Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa B, Peterhoff C, Cataldo A, Rudnicki A, Li B-S, Pant HC, Hungund L, Arancio O, Nixon RA. Calpain mediates calcium-induced activation of the Erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer’s disease. Am J Pathol 2004; 165:795-805. PMC1618589 HTML PDF
  80. Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD, Nixon RA, Levy E. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid b peptide. J Molecular Neuroscience, 2004; 22 (1-2): 13-8. PMID: 14742906
  81. Helpern JA, Lee S-P, Falangola MF, Dyakin VV, Bogart A, Estok K, Ardekani B, Duff K, Branch C, Wisniewski T, deLeon MJ, Wolf O, O’Shea J, Wegiel J, Nixon RA. Magnetic resonance imaging assessment of neuropathology in a transgenic mouse model of Alzheimer’s disease. Magn Reson Medicine, 2004; 51:794-798. PMID:15065253
  82. Laudon H, Mathews PM, Karlström H, Berman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, & Näslund J. Co-expressed presenilin 1 NTF and CTF form functional g-secretase complexes in cells devoid of full-length protein. J Neurochem, 2004; 89:44-53.
  83. Sadowski M, Pankiewicz J, Scholtzova H, Yong J, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, and Wisniewski T. Amyloid-b deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. JNEN, 2004; 63:418-428. PMID:15198121
  84. Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker SD, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, Laska E, Ehrlich ME, Walker LC, Mathews PM, Gandy S. Aging, gender, and apoE isotype modulate metabolism of Alzheimer’s Ab peptides and F2-isoprostane biomarkers in the absence of detectable amyloid deposits. J. Neurochemistry 2004;90:1011-1018. PMID: 15287908
  85. Noble W, Olm V, Takata K, Casey E, O M, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, Matsuoka Y, Ahlijanian M, Lau L-F, Duff K. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 2003; 38:555-565. PMID:12765608
  86. Battaglia F, Trinchese F, Liu S, Walter S, Nixon RA, Arancio O. Calpain inhibitors, a treatment for Alzheimer's disease: position paper. J Mol Neurosci. 2003 Jun;20(3):357-62. PMID: 14501020
  87. Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, and Nixon RA. App gene dosage modulates endosomal abnormalities of Alzheimer’s disease in a trisomy 16 mouse model of Down syndrome. J Neurosci. 2003; 23(17):6788-6792. PMID: 12890772
  88. Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinaker R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular bCTF levels and Ab production. J Biol Chem. 2003; 278(33):31261-31268. PMID: 12761223 Full text available: HTML PDF
  89. Yuan A, Rao MV, Kumar A, Julien J-P, Nixon RA. Neurofilament transport in vivo requires hetero-oligomer formation. J Neurosci. 2003; 23(28):9452-9458. PMID:14561875 Full text available: HTML PDF
  90. Phinney AL, Drisaldi B, Lugowski S, Schmidt SD, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Mathews PM, Nixon RA, Carlson GA, St George-Hyslop P, Westaway D. In vivo reduction of Ab by a mutant CuATPase7b transporter. Proc. Natl. Acad. Sci. USA. 2003; 100:14193-14198. PMC283568 HTML PDF
  91. Rao MV, Campbell J, Yuan A, Kumar A, Gotow T, Uchiyama Y, Nixon RA. The neurofilament middle molecular weight subunit carboxyl terminal tail domains are essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate. J Cell Biol 2003; 163:1021-1031. PMC2173612 HTML PDF
  92. Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA. Calpain activity regulates the cell surface distribution of amyloid precursor protein: inhibition of calpains enhances endosomal generation of b-cleaved C-terminal APP fragments. J Biol Chem 2002; 277:36415-36424. PMID: 12087104 Full text available: HTML PDF
  93. Di Rosa G, Odrijin T, Nixon RA, Arancio O. Calpain inhibitors: a treatment for Alzheimer's disease. J Molec Neurosci. 2002 Aug-Oct;19(1-2):135-41. PMID: 12212771
  94. Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, Fraser P, Westaway D, St. George-Hyslop P. Alleles at the nicastrin locus modify presenilin 1-deficiency phenotype. Proc Nat Acad Sci USA 2002; 99:14452-14457. PMC137904 HTML PDF
  95. Adamec E, Mohan PS, Vonsattel JP, Nixon RA. Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. Acta Neuropathologica 2002; 104:92-104. PMID: 12070670
  96. Adamec E, Murrell JR, Takao M, Hobbs W, Nixon RA, Ghetti B, Vonsattel JP. P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein. J Neurol Sci 2002; 200:85-93. PMID: 12127682
  97. Rao, MV, Engle LJ, Mohan PS, Yuan A, Qiu D, Cataldo A, Hassinger L, Jacobsen S, Lee VM-Y, Andreadis A, Julien J-P, Bridgman PC, Nixon RA. Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J Cell Biol 2002; 159:279-289. PMC2173037 HTML PDF
  98. Rao MV, Garcia ML, Miyazaki Y, Gotow T, Yuan A, Mattina S, Ward CM, Calcutt NA, Uchiyama Y, Nixon RA, Cleveland DW. Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol 2002; 158:681-693. PMCID: PMC2174004 HTML PDF
  99. Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. Alzheimer’s disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Ab secretion: Role for altered lysosomal hydrolase distribution in b-amyloidogenesis. J Biol Chem 2002; 277:5299-5307. PMID: 11551970 Full text available: HTML PDF
  100. Yang D-S, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt, SD, Triprayer V, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HTJ, St. George-Hyslop P, Fraser PE. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J Biol Chem 2002; 277:28135-28142. PMID: 12032140
  101. Adamec E, Yang F, Cole GM, Nixon RA. Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration. Brain Res Protocols 2001; 7:193-202. PMID: 11431120
  102. Nixon RA, Mathews PM, Cataldo AM. The neuronal endosomal-lysosomal system in Alzheimer’s disease. Journal of Alzheimer’s Disease 2001; 3:97-107.
  103. Cataldo AM, Rebeck GW, Ghetti B, Hulette C, Lippa C, Van Broeckhoven C, van Duijn C, Cras P, Bogdanovic N, Bird T, Peterhoff CM, Nixon RA. Endocytic disturbances distinguish among subtypes of Alzheimer’s disease and related disorders. Ann Neurol 2001; 50:661-665. PMID: 11706973
  104. Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid b deposition in sporadic Alzheimer’s disease and Down syndrome. Am J Path 2000; 157:277-286. PMC1850219 HTML PDF
  105. Sanchez I, Hassinger L, Sihag RK, Cleveland DW, Mohan P, Nixon RA. Local control of neurofilament accumulation during radial growth of myelinating axons In Vivo: Selective role of site- specific phosphorylation. J Cell Biol 2000; 151:1013-1024. PMC2174358 HTML PDF
  106. Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Levesque L, Fraser PE, Andreadis A, Nixon RA. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer’s disease. Molec Medicine 2000; 6:878-891. PMC1949913 HTML PDF
  107. Adamec E, Mohan PS, Cataldo AM, Vonsattel JP, Nixon RA. Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer’s disease. Neuroscience 2000; 100:663-675. PMID: 11098128
  108. Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HTJ, Nixon RA, Mercken M, Bergeron C, Fraser PE, St. George- Hyslop P, Westaway D.Ab peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer’s disease. Nature 2000; 408:979-982. PMID: 11140685
  109. Anderson AJ, Stoltzner S, Lai F, Su J, Nixon RA. Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. Neurobiology of Aging 2000; 21:511-524. PMID: 10924764
  110. Buchner K, Adamec E, Beermann ML, Nixon RA. Isoform-specific translocation of protein kinase C following glutamate administration in primary hippocampal neurons. Molec Brain Res 1999; 64:222-235.
  111. Sihag RK, Jaffe H, Nixon RA, Rong X. Serine-23 is a major protein kinase a phosphorylation site on the amino-terminal head domain of the middle molecular mass subunit of neurofilament proteins. J Neurochem 1999; 72:491-499.
  112. Lai F, Kammann E, Rebeck GW, Anderson A, Chen Y, Nixon RA. APOE genotype and gender effects on Alzheimer’s disease in 100 adults with Down syndrome. Neurology 1999; 53:331-336.
  113. Levesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St. George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molec Medicine 1999; 5:542- 554. HTML PDF
  114. Adamec E, Vonsattel JP, Nixon RA. DNA strand breaks in Alzheimer’s disease. Brain Res 1999; 849:67-77.
  115. Shiurba RA, Spooner ET, Ishiguro K, Takahashi M, Yoshida R, Wheelock TR, Imahori K, Cataldo AM, Nixon RA. Immunocytochemistry of formalin-fixed human brain tissues: microwave irradiation of free-floating sections. Brain Res Protocols 1998; 2:109-119.
  116. Li J, Nixon RA, Messer A, Berman S, Bursztajn S. Altered gene expression for calpain/calpastatin in motor neuron degeneration (mnd) mutant mouse brain and spinal cord. Molec Brain Res 1998; 53:174-186.
  117. Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer’s disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 1998; 273:3205 - 3211.
  118. Adamec E, Beerman ML, Nixon RA. Calpain I activation in rat hippocampal neurons in culture is NMDA receptor selective and not essential for excitotoxic cell death. Molec Brain Res 1998; 54:35-48.
  119. Troncoso J, Cataldo AM, Nixon RA, Barnett JL, Lee MK, Checler F, Fowler DR, Smialek JE, Crain B, Martin LJ, Kawas CH. Neuropathology of preclinical and clinical late-onset Alzheimer’s disease. Annals of Neurology 1998; 43:673-676.
  120. Adamec E, Didier M, Nixon RA. Developmental regulation of the recovery process following glutamate-induced calcium rise in rodent primary neuronal cultures. Devel Brain Res 1998; 108:101-110.
  121. Wang KK, Posmantur R, Nadimpalli R, Nath R, Mohan P, Nixon RA, Talanian RV, Keegan M, Herzog L, Allen H. Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis. Arch Biochem Biophys 1998; 356:187-196.
  122. Grynspan F, Griffin WB, Mohan PS, Shea TB, Nixon RA. Calpains and calpastatin in SH-Sy5Y neuroblastoma cells during retinoic acid induced differentiation and neurite outgrowth: Comparison to the human brain calpain system. J Neurosci Res 1997; 48:181-191.
  123. Grynspan F, Griffin WR, Cataldo A, Katayama S, Nixon RA. Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer’s disease. Brain Res 1997; 763:145-158.
  124. Shea TB, Dahl DC, Nixon RA, Fischer I. Triton-soluble phosphovariants of the heavy neurofilament subunit in developing and mature mouse central nervous system. J Neurosci Res 1997; 48:515-523.
  125. Adamec E, Mercken M, Beerman ML, Didier M, Nixon RA. Acute rise in the concentration of free cytoplasmic calcium leads to dephosphorylation of the microtubule-associated protein tau. Brain Res 1997; 757:93-101.
  126. Cataldo AM, Barnett JL, Pieroni C, Nixon RA. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer’s disease: neuropathologic evidence for a mechanism of increased b-amyloidogenesis. J Neurosci 1997; 17:6142-6151.
  127. Capell A, Saffrich R, Olivo J-C, Meyn L, Walter J, Grunberg J, Mathews P, Nixon RA, Dotti C, Haass C. Cellular expression and protelytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. J Neurochem 1997; 68:2432-2440.
  128. Li J, Grynspan F, Berman S, Nixon R, Bursztajn S. Regional differences in gene expression for the calcium activated neutral proteases (calpains) and their endogenous inhibitor (calpastatin) in the mouse brain and spinal cord. J Neurobiol 1996; 30(2):177-191.
  129. Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA. Properties of the endosomal-lysosomal system in the human central nervous system: Disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Neurosci 1996; 16:186-99.
  130. Didier M, Bursztajn S, Adamec E, Passani L, Nixon RA, Coyle JT, Wei JY, Berman SA. DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures. J Neurosci 1996; 16:2238­-2250.
  131. Shea TB, Spencer MJ, Beermann ML, Cressman CM, Nixon RA. Calcium influx into human neuro­blastoma cells induces ALZ-50 immunoreactivity: Involvement of calpain-mediated hydrolysis of protein kinase C. J Neurochem 1996; 66:1539-49.
  132. Cataldo AM, Barnett JL, Mann DA, Nixon RA. Colocalization of lysosomal hydrolase and b-amyloid in diffuse plaques of Alzheimer's disease and Down's syndrome. J Neuropathol Exp Neurol 1996; 55(6):704-715.
  133. Shiurba RA, Ishiguro K, Takahashi M, Sato K, Spooner ET, Mercken M, Yoshida R, Wheelock TR, Yanagawa H, Imahori K, Nixon, RA. Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology. Brain Res 1996; 737:119-132.
  134. Sanchez I, Hassinger L, Paskevich P, Shine HD, Nixon RA. Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myeline formation. J Neurosci 1996; 16:5095-5105.
  135. Kampfl A, Posmantur R, Nixon R, Grynspan F, Zhao X, Liu SJ, Newcomb JK, Clifton GL, Hayes RL. Calpain I activation and calpain I mediated cytoskeletal proteolysis following traumatic brain injury. J Neurochem 1996; 67(4):1575-1583.
  136. Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA. Abnormalities of the endosomal-lysosomal system in Alzheimer’s Disease: relationship to disease pathogenesis. Adv Exp Med Biol 1996; 389:271-80.
  137. Cataldo AM, Barnett JL, Berman SA, Li J, Quarless S, Bursztajn S, Lippa C, Nixon RA. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up‑regulation of the endosomal‑lysosomal system. Neuron 1995; 14:671-80.
  138. Schwagerl AL, Mohan PS, Cataldo AM, Vonsattel JP, Kowall NW, Nixon RA. Elevated levels of the endosomal‑lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease. J Neurochem 1995; 64:443‑6.
  139. Mohan PS, Nixon RA. Purification and properties of high molecular weight calpastatin from bovine brain. J Neurochem 1995; 64: 859-66.
  140. Compaine A, Schein JD, Tabb JS, Mohan PS, Nixon RA. Limited proteolytic processing of the mature form of cathepsin D in human and mouse brain: Postmortem stability of enzyme structure and activity. Neurochem Intl 1995; 27:385-96.
  141. Shea TB, Beermann ML, Nixon RA. Aluminum treatment of intact neuroblastoma cells alters neurofilament sub­unit phosphorylation, solubility and proteolysis. Molec Chem Neuropathol 1995; 26:1-14.
  142. Cressman CM, Mohan PS, Nixon RA, Shea TB. Proteolysis of protein kinase C: mM and mu M calcium-requiring calpains have different abilities to generate, and degrade the free catalytic subunit, protein kinase M. FEBS Lett 1995; 367:223-7.
  143. Shea TB, Cressman CM, Spencer MJ, Beermann ML, Nixon RA. Enhancement of neurite outgrowth follow­ing calpain inhibition is mediated by protein kinase C. J Neurochem 1995; 65:517-27.
  144. Mercken M, Grynspan F, Nixon RA. Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF‑tau. FEBS Lett 1995; 368:10-14.
  145. Mercken M, Fischer I, Kosik KS, Nixon RA. Three distinct axonal transport rates for tau, tubulin and other microtubule-associated proteins: Evidence for dynamic interactions of tau with microtubules in vivo. J Neurosci 1995; 15:8259-67.
  146. Shea TB, Beermann ML, Honda T, Nixon RA. Secretion of amyloid precursor protein and laminin by cultured astrocytes is influenced by culture conditions. J Neurosci Res 1994; 37:197-207.
  147. Cataldo AM, Hamilton DJ, Nixon RA. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain Res 1994; 640:68-80.
  148. Nixon RA, Paskevich PA, Sihag RK, Thayer C. Phosphorylation on carboxyl terminus domains of neuro­filament proteins in retinal ganglion cell neurons in vivo: Influences on regional neurofilament accu­mu­la­tion, interneurofilament spacing, and axon caliber. J Cell Biol 1994; 126:1031-46.
  149. Nixon RA, Lewis SE, Mercken M, Sihag RK. [32P]Orthophosphate and [35S]methionine label separate pools of neurofilaments with markedly different axonal transport kinetics in mouse retinal ganglion cells in vivo. Neurochem Res 1994; 19:1445-53 (Festschrift issue).
  150. Sihag RK, Wang L, Cataldo AM, Hamlin M, Cohen C, Nixon RA. Evidence for the association of protein 4.1 immunoreactive forms with neurofibrillary tangles in Alzheimer's disease brains. Brain Res 1994; 656:14-26.
  151. Burke WJ, Galvin NJ, Hyung DC, Stoff SA, Gillespie KN, Cataldo AM, Nixon RA. Degenerative changes in epinephrine tonic vasomotor neurons in Alzheimer's disease. Brain Res 1994; 661:35-42.
  152. Leli U, Shea TB, Cataldo A, Hauser G, Grynspan F, Beermann ML, Liepkalns VA, Nixon RA, Parker PJ. Differential expression and subcellular localization of protein kinase C alpha, beta, gamma, delta, and epsilon isoforms in SH‑SY5Y neuroblastoma cells: Modifications during differentiation. J Neurochem 1993; 60:289-98.
  153. Saito K‑I, Elce JS, Hamos JE, Nixon RA. Widespread activation of calcium‑activated neutral proteinase (calpain) in the brain in Alzheimer disease: A potential molecular basis for neuronal degeneration. Proc Nat Acad Sci USA 1993; 90:2628-32.
  154. Saito K‑S, Nixon RA. Specificity of calcium‑activated neutral proteinase (CANP) inhibitors for human muCANP and mCANP. J Neurochem Res 1993; 18(2):231-3. HTML PDF
  155. Albert M, Jenike M, Nixon R, Nobel K. Thyrotropin response to thyrotropin‑ releasing hormone in patients with dementia of the Alzheimer type. Biol Psychiatry 1993; 33:267-71.
  156. Takeuchi KS, Saito K‑I, Nixon RA. Immunoassay and activity of calcium‑activated neutral proteinase (mCANP): Distribution in soluble and membrane‑associated fractions in human and mouse brain. J Neurochem. 1992; 58:1526-32.
  157. Shea TB, Beermann ML, Nixon RA. Sequential effects of astroglial‑derived factors on neurite outgrowth: Initiation by protease inhibitors and potentiation by extra­cellular matrix components. J Neurosci Res 1992; 31:309-17.
  158. Shea TB, Beermann ML, Nixon RA. Aluminum alters the electrophoretic properties of neurofilament proteins: Role of phosphorylation state. J Neurochem 1992;58:542-7.
  159. Leli U, Cataldo A, Shea TB, Nixon RA, Hauser G. Distinct mechanisms of differentia­tion of SH‑SY5Y neuroblastoma cells by protein kinase C activators and inhibitors. J Neurochem 1992; 58:1191-8.
  160. Shea TB, Beermann ML, Nixon RA. Complementary effects of laminin and protease inhibitors on neurite outgrowth and maintenance. Neurosci Res Commun 1992; 10:53-61.
  161. Shea TB, Beermann ML, Nixon RA, Fischer I. Microtubule‑associated protein tau is required for axonal neurite elaboration by neuroblastoma cells. J Neurosci Res 1992; 32:363-74.
  162. Shea TB, Beermann ML, Leli U, Nixon RA. Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: Initiation by kinase A and restriction by kinase C. J Neurosci Res 1992; 33:398-407.
  163. Cataldo AM, Paskevich PA, Kominami E, Nixon RA. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease. Proc Nat Acad Sci USA, 1991; 88:10998-11002. HTML PDF
  164. Shea TB, Beermann ML, Nixon RA. Multiple proteases regulate neurite outgrowth in NB2a/d1 neuroblastoma cells. J Neurochem 1991; 56:842-51.
  165. Sihag RK, Nixon RA. Identification of Ser‑55 as a major protein kinase A phos­phorylation site on the 70‑kDa subunit of neurofilaments: Early turnover during axonal transport. J Biol Chem 1991; 266:18861-7.
  166. Cataldo AM, Nixon RA. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proc Nat Acad Sci USA 1990; 87:3861-5. HTML PDF
  167. Cataldo AM, Thayer CY, Bird ED, Wheelock TR, Nixon RA. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: Evidence for a neuronal origin. Brain Res 1990; 513:181-92.
  168. Shea TB, Beermann ML, Nixon RA. Post‑translational modification of a‑tubulin by acetylation and detyrosination in NB2a/d1 neuroblastoma cells. Devel Brain Res 1990; 51:195-204.
  169. Nixon RA, Fischer I, Lewis SE. Synthesis, axonal transport and turnover of the high molecular weight microtubule‑associated protein MAP 1A in mouse retinal ganglion cells: Tubulin and MAP 1A display distinct transport kinetics. J Cell Biol. 1990; 110:437-48.
  170. Sihag RK, Nixon RA. Phosphorylation of the amino‑terminal head domain of the middle molecular mass 145‑kDa subunit of neurofilaments: Evidence for regulation by second messenger‑dependent protein kinases. J Biol Chem. 1990; 265:4166-71.
  171. Canoso RT, de Oliveira RM, Nixon RA. Neuroleptic‑associated autoantibodies. A prevalence study. Biol Psychiatry 1990; 27:863-70.
  172. Nixon RA, Clarke JF, Logvinenko KB, Tan MKH, Hoult M, Grynspan F. Aluminum inhibits calpain‑mediated proteolysis and induces human neurofilament proteins to form protease‑resistant high molecular weight complexes. J Neurochem 1990; 55:1950-9.
  173. Shea TB, Sihag RK, Nixon RA. Dynamics of phosphorylation and assembly of the high molecular weight neurofilament subunit in NB2a/d1 neuroblastoma. J Neurochem 1990; 55:1784-92.
  174. Nixon RA, Lewis SE, Dahl D, Marotta CA, Drager UC. Early posttranslational modifications of the three neurofilament subunits in mouse retinal ganglion cells: neuronal sites and time course in relation to subunit polymerization and axonal transport. Molec Brain Res 1989; 5:93-108.
  175. Sihag RK, Nixon, RA. In vivo phosphorylation of distinct domains of the 70‑kilodalton neurofilament subunit involves different protein kinases. J Biol Chem 1989; 264:457‑64.
  176. Shea TB, Clarke JF, Wheelock TR, Paskevich PA, Nixon RA. Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/d1 neuroblastoma. Brain Res 1989; 492:53-64.
  177. Shea TB, Beermann ML, Nixon RA. Appearance and localization of phosphorylated variants of the high molecular weight neurofilament protein in NB2/d1 cytoskeletons during differentiation. Devel Brain Res 1989; 50:142-6.
  178. Falk WE, Rosenbaum JT, Otto MW, Zusky PM, Weilburg JF, Nixon RA. Fluoxetine versus trazodone in depressed geriatric patients. J Geriatric Psychiatry Neurol 1989; 2:208-14.
  179. Shea TB, Majocha RE, Marotta, CA, Nixon RA. Soluble, phosphorylated forms of the high molecular weight neurofilament protein in perikarya of cultured neuronal cells. Neurosci Lett 1988; 92:291-7.
  180. Shea TB, Nixon RA. Differential distribution of vimentin and neurofilament protein immunoreactivity in NB2a/d1 neuroblastoma cells following neurite retraction distinguishes two separate intermediate filament systems. Devel Brain Res 1988;41:298-302.
  181. Shea TB, Sihag RK, Nixon RA. Neurofilament triplet proteins of NB2a/d1 neuro­blastoma: posttranslational modification and incorporation into the cytoskeleton during differentiation. Devel Brain Res 1988; 43:97-109.
  182. Sihag RK, Jeng AY, Nixon RA. Phosphorylation of neurofilament proteins by protein kinase C. FEBS Lett 1988; 233:181-5.
  183. Pope HG, Jr, McElroy SL, Nixon RA. Possible synergism between fluoxetine and lithium in refractory depression. Am J Psychiatry 1988; 145:1292-4.
  184. Lewis SE, Nixon RA. Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: Characterization and evidence for their differential association with stationary and moving neurofilaments. J Cell Biol 1988; 107:2689-2701.
  185. Nixon RA, Lewis SE, Marotta CA. Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons. J Neurosci 1987; 7(4):1145-58.
  186. Nixon RA, Quackenbush R, Vitto A. Multiple calcium‑activated neutral proteinases (CANP) in mouse retinal ganglion cell neurons: Specificities for endogenous neuronal substrates and comparison to purified brain CANP. J Neurosci 1986; 6:1252-63.
  187. Nixon RA. Fodrin degradation by calcium‑activated neutral proteinase (CANP) in retinal ganglion cell neurons and optic glia: Preferential localization of CANP activities in neurons. J Neurosci 1986; 6:1264-71.
  188. Nixon RA, Logvinenko KB. Multiple fates of newly synthesized neurofilament proteins: Evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons. J Cell Biol 1986; 102:647-59.
  189. Pope HG Jr, Hudson JI, Nixon RA, Herridge PL. The epidemiology of Ipecac abuse. New England J Med 1986; 314:245-6.
  190. Fleming N, Nixon RA. A versatile transition metal salt reaction for a wide range of common biochemical reagents; An instantaneous and quantifiable color test. Analyt Biochem 1986; 154:691-701.
  191. Vitto A, Nixon RA. Calcium‑activated neutral proteinase of human brain: Subunit structure and enzymatic properties of multiple molecular forms. J Neurochem 1986; 47:1039-51.
  192. Zubenko GS, Marquis JK, Volicer L, Direnfeld LK, Langlais PJ, Nixon RA. Cerebrospinal fluid levels of angiotensin‑converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: A correlative study. Biol Psychiatry 1986; 21:1365-81.
  193. Nixon RA, Lewis SE. Differential turnover of phosphate groups on neurofilament subunits in mammalian neurons in vivo. J Biol Chem 1986; 261:16298-30l.
  194. Zubenko GS, Volicer L, Direnfeld LK, Freeman M, Langlais PJ, Nixon RA. Cerebrospinal fluid levels of angiotensin‑converting enzyme in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy. Brain Res 1985; 328:215-21.
  195. Zubenko GS, Nixon RA. Captopril and teprotide as discriminators of angio­tensin‑converting enzyme activity in brain tissue. Neurosci Lett 1985; 60:33-7.
  196. Zubenko GS, Nixon RA. Mood‑elevating effect of captopril in depressed patients. Am J Psychiatry 1984; 141:110-11.
  197. Nixon RA, Marotta CA. Degradation of neurofilament proteins by purified human brain cathepsin D. J Neurochem 1984; 43:507-16.
  198. Nixon RA, Brown BA, Marotta CA. Limited proteolytic modification of a neuro­filament protein involves a proteinase activated by endogenous levels of calcium. Brain Res 1983; 275:384-88.
  199. Nixon RA, Chin WW. Water intoxication and antidiuretic hormone. Am J Psychiatry 1983;140:815.
  200. Nixon RA. Increased axonal proteolysis in myelin‑deficient mutant mice. Science 1982; 215:999-1001.
  201. Nixon RA, Brown BA, Marotta CA. Posttranslational modification of a neurofilament protein during axoplasmic transport: Implications for regional specialization of axons. J Cell Biol 1982; 94:150-8.
  202. Brown BA, Nixon RA, Marotta CA. Posttranslational processing of a-tubulin during axoplasmic transport in CNS axons. J Cell Biol 1982; 94:159-64.
  203. Nixon RA, Rothman JS, Chin W. Demeclocycline in the prophylaxis of self‑induced water intoxication. Am J Psychiatry 1982; 139:828-30.
  204. Nixon RA. Water intoxication and lithium. Am J Psychiatry 1982; 139:1525.
  205. Brown BA, Nixon RA, Strocchi P, Marotta CA. Characterization and comparison of neurofilament proteins from rat and mouse CNS. J Neurochem 1981; 36:143-53.
  206. Pope A, Amelotte JA, Belfer H, Nixon RA. Protease activities in normal and schizophrenic human prefrontal cortex and white matter. Neurochem Res 1981; 6:1043-52.
  207. Nixon RA. Protein degradation in the mouse visual system I. Degradation of axonally transported and retinal proteins. Brain Res 1980; 200:69-83.
  208. Nixon RA. Quinine sulfate for pain in the Guillain‑Barre syndrome. Ann Neurol 1978; 4:386-7.
  209. LaVail JH, Nixon RA, Sidman RL. Genetic control of retinal ganglion cell projections. J Comp Neurol 1978; 182:399-421.
  210. Nixon RA, Karnovsky ML. Uptake and metabolism of intraventricularly administered piperidine and its effects on sleep and wakefulness in the rat. Brain Res 1977; 134:501-11.
  211. Nixon RA, Suva M, Wolf MK. Neurotoxicity of a non‑metabolizable amino acid, 1‑aminocyclo­pentane‑1‑carboxylic acid: Antagonism by amino acids in cultures of cerebellum. J Neurochem 1976; 27:245-51.
  212. Nixon RA. Neurotoxicity of a non‑metabolizable amino acid, 1‑aminocyclopentane‑1‑ carboxylic acid: Regional protein levels and lipid composition of nervous tissue. J Neurochem 1976; 27:237-44.
  213. Nixon R. Neurotoxicity of a non‑metabolizable amino acid, 1‑aminocyclopentane-1- carboxylic acid: (ACPC): ACPC transport mechanisms in tissues. Biochem Pharmacol 1976; 25:726-29.
  214. Nixon R. Volatile amines in mouse brain: A radioassay with picogram sensitivity. Analyt Biochem 1972; 48:460-70.
  215. Nixon R, Kanfer JN. Comparison of cerebral sphingolipid metabolism in vivo in "Quaking" and normal mice. Life Sciences 1971; 10:71-79.
  216. Patterson D, Weinstein M, Nixon R, Gillespie D. Interaction of ribosomes and the cell envelope of Escherichia coli mediated by lysozyme. J Bacteriol 1970; 101:585-91.
  217. Boyd D, Nixon R, Gillespie S, Gillespie D. Screening of Escherichia coli temperature sensitive mutants by pretreatment with glucose starvation. J Bacteriol 1968; 94:1040-50.

Reviews, Books, and Book Chapters

  1. Alzheimer's Association National Plan Milestone Workgroup, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Filit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC. 2014 Report on the milestones for the US national plan to address Alzheimer's disease. Alz Dement 2014, 10(5 Suppl):S430-52. Click for abstract Free full text
  2. Nixon RA. The role of autophagy in neurodegenerative disease. Nature Med 2013; 19(8):983-97. PMID: 23921753 Click for abstract
  3. Nixon RA, Yang DS. Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb Perspect Biol 2012; 4(10):pii a008839. PMID: 22983160 Click for abstract
  4. Yuan A, Rao MV, Veeranna, Nixon RA. Neurofilaments at a glance. J Cell Sci. 2012;125(Pt 14):3257-63. Click for abstract
  5. Ihara Y, Morishima-Kawashima M, Nixon RA. The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. In: The Biology of Alzheimer Disease. Selkoe D, Holtzman D, Mandelkow E (Eds.). Woodbury NY, USA: Cold Spring Harbor Laboratory Press., in press. [Chapter 19] ISBN:978-1-936113-44-6 HTML PDF
  6. Schmidt SD, Nixon RA, Mathews PM. Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites including Abeta. Methods Mol Biol 2012, 849:493-506. Click for abstract
  7. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT…Nixon RA…et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2012; 8(4):445-544.
  8. Nixon RA, Yang DS. Autophagy failure in Alzheimer’s disease – locating the primary defect. Neurobiol Dis 2011; 43(1):38-45. PMC3096679.
  9. Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Therapeutic effects of remediating autophagy failure in mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy. 2011; 7(7):788-9. PMCID: PMC3359468HTML PDF
  10. Lee S, Saito Y, Nixon RA. Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer's - like neuritic dystrophy. Autophagy 2011, 7(12).
  11. Wolfe DM, Nixon RA. Autophagy failure in Alzheimer’s disease and lysosomal storage disorders: A common pathway to neurodegeneration. In: Autophagy of the Nervous System: Cellular self-digestion in neurons and neurological diseases. Yue Z, Chu CT (Eds.). Hackensack, NJ, USA: World Scientific Publishing Co., Inc., in press. [Chapter 17] ISBN:978-981-4350-44-0
  12. Ihara Y, Morishima-Kawashima M, Nixon RA. The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. In: The Biology of Alzheimer Disease. Selkoe D, Holtzman D, Mandelkow E (Eds.). Woodbury NY, USA: Cold Spring Harbor Laboratory Press., in press. [Chapter 19] ISBN:978-1-936113-44-6
  13. Yuan A, Nixon RA. Alpha-internexin: The fourth subunit of neurofilaments in the mature CNS. In: Cytoskeleton of the Nervous System, Vol 3; A. Yuan, R.A. Nixon (Eds.); Advances in Neurobiology, A. Lajtha (Ed.) New York: Springer Publication, 2011 pp.189-200 [Chapter 8]. ISBN-13: 978-1-4419-6786-2
  14. Yuan A, Nixon RA. Axonal transport mechanisms in cytoskeleton formation and regulation. In: Cytoskeleton of the Nervous System, Vol 3; A. Yuan, R.A. Nixon (Eds.); Advances in Neurobiology, A. Lajtha (Ed.) New York: Springer Publication, 2011 pp.503-528 [Chapter 21]. ISBN-13: 978-1-4419-6786-2
  15. Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH. Amyloid-independent mechanisms in Alzheimer’s disease pathogenesis. J Neurosci 2010, 30:14946-54
  16. Wesson DW, Wilson DA, Nixon RA. Should olfactory dysfunction be used as a biomarker of Alzheimer’s disease? Exp Rev Neurotherapeutics 2010; 10:633-635.
  17. Yang DS, Lee J-H, Nixon RA.  Monitoring autophagy in Alzheimer’s disease and related neurodegenerative diseases Methods Enzymol 2009; 453:111-44.
  18. Wilson DA, Nixon RA. Sniffing out a function for prion proteins. Nat Neurosci 2009; 12:7-8.
  19. Basavarajappa BS, Nixon RA, Arancio O. Endocannabinoid system: Emerging role from neurodevelopment to neurodegeneration. Mini-Rev Medicinal Chem. 2009; 9:448-462.
  20. Nixon RA, Yang DS, Lee J-H. Neurodegenerative lysosomal disorders: A continuum from development to late age. Autophagy 2008; 4:590-599.
  21. Nixon RA. Autophagy, amyloidogenesis and Alzheimer’s disease. J Cell Sci. 2007; 120:4081-4091 PMID: 18032783.
  22. Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, Stefanis L, Tolkovsky A. Autophagy and its possible roles in nervous system diseases, damage and repair.  Autophagy 2006; 1:11-22 PMID:16874045.
  23. Nixon RA and Cataldo AM. Lysosomal system pathways: Genes to neurodegeneration in Alzheimer’s disease. J  Alzheimer’s Dis 2006; 9:277-289 PMID :16914867.
  24. Nixon RA.  Autophagy in neurodegenerative disease:  friend, foe, or turncoat? Trends in Neurosci 2006; 29:528-535 PMID:16859759.
  25. Cataldo AM and Nixon RA.  Neuronal trafficking in Alzheimer disease Niemann-Pick Type C disease.  IN: Protein Trafficking in Neurons.  Bean A (ed).  Elsevier Neurosci, Elsevier Publications, Amsterdam, Netherlands, 2006; pp 391-411. ISBN: 978-0-12-369437-9
  26. Butler D, Nixon RA, Bahr BA.  Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases.  Autophagy 2006; 2:234-237 PMID:16874061.
  27. Boland B, Nixon RA.  Neuronal macroautophagy: from development to degeneration.  Mol Aspects Med 2006; 27:503-519 PMID:16999991.
  28. Nixon RA. Endosome function and dysfunction in Alzheimer’s disease and other neurodegenerative diseases. Neurobiology of Aging 2005; 26:373-382. PMID: 15639316
  29. Schmidt SD, Nixon RA, Mathews PM. ELISA method for measurement of amyloid-b levels. Methods in Molecular Biology: Amyloid Proteins, Methods and Protocols (Sigurdsson EM, editor), The Humana Press, Inc., Totowa, NJ, 2005; 299:279-297 PMID: 15980612. 
  30. Schmidt SD, Jiang Y, Nixon RA, Mathews PM. Tissue processing prior to protein analysis and amyloid-b quantitation.  Methods in Molecular Biology: Amyloid Proteins, Methods and Protocols (Sigurdsson EM, editor), The Humana Press, Inc., Totowa, NJ, 2005; 299:267-278 PMID:15980611.
  31. Nixon RA.  Niemann-Pick Type C disease and Alzheimer’s disease: The APP-endosome connection fattens up. American Journal of Pathology 2004; 164(3): 757-61. HTML PDF
  32. Tatton W, Chen D, Chalmers-Redman R, Wheeler L, Nixon R, Tatton N. Nixon RA. Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer’s disease: anti-apoptosis by alpha-2-adrenergic receptor activation. Survey of Ophthalmology 2003; 48: Supplement 1 p:S25- S37.
  33. Rao MV and Nixon RA. Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: A review. Neurochem Res 2003; 28:1041-1047.
  34. Mathews PM, Nixon RA. Setback for an Alzheimer’s disease vaccine: Lessons learned. Neurology 2003; 61:7-8.
  35. Nixon RA. The calpains in aging and aging-related diseases. Ageing Research Reviews 2003; 2:407-418.
  36. Nixon RA. Neural circuitry and signaling in dementia and Alzheimer’s disease. In: Brain Circuitry and Signaling in Psychiatry: Basic Science and Clinical Implications. Kaplan GB and Hammer RP, Jr. (eds.) American Psychiatric Publishing, Inc., WDC, 2002; 201-226.
  37. Nixon RA. Cell and molecular neuropathology of Alzheimer’s disease. In: Neuropsycho- pharmacology: The Fifth Generation of Progress; Davis KL, Charney D, Coyle JT, and Nemeroff C (eds.) American College of Neuropsychopharmacology 2002; Lippincott Williams & Wilkins, Philadelphia, PA.
  38. Nixon RA and Rao MV. Neurofilaments. In: Encyclopedia of Molecular Medicine. Creighton TE(ed.). John Wiley & Sons, Inc., New York 2001; 1589-1595.
  39. Nixon RA, Cataldo AM, Mathews PM. The endosomal-lysosomal system of neurons in Alzheimer’s disease pathogenesis: a review. Neurochem Res 2000; 25:1161-1172.
  40. Nixon RA. A ‘protease activation cascade’ in the pathogenesis of Alzheimer’s disease. In: Alzheimer’s Disease: A Compendium of Current Theories. Khachaturian ZS and Mesulam MM(eds.) Ann NY Acad Sci 2000; 924:117-131.
  41. Nixon RA. “Neurofilaments” In: Encyclopedia of Molecular Biology. Creighton TE (ed.) Wiley, New York, 1999; 1589-1595.
  42. Nixon RA, Mohan PS. “Calpains in the pathogenesis of Alzheimer’s disease” In: Calpain: Pharmacology and Toxicology of Calcium-Dependent Protease. Taylor & Francis, Ann Arbor1999, 267-291.
  43. Nixon RA. The dynamic behavior and organization of cytoskeletal proteins in neurons: Reconciling old and new findings. Bioessays 1998; 20:798-807.
  44. Nixon RA. Slow axonal transport of cytoskeletal proteins. Current Opinion in Cell Biol 1998; 10:87-92.
  45. Nixon RA. The slow axonal transport debate. Trends in Cell Biology 1998; 8:100.
  46. Nixon RA, Albert MS. Disorders of cognition. In: The Harvard Guide to Modern Psychiatry. Nicoli A (ed.) Harvard University Press, Cambridge, 1998; 328-361.
  47. Nixon RA, Cataldo AM. The endosomal‑lysosomal system in Alzheimer disease. Intl Comm on Proteolysis Newsletter, Feb. 1995.
  48. NixonRA, Cataldo AM. The endosomal‑lysosomal system of neurons: New roles.Trends Neurosci 1995; 18:489-96.
  49. Nixon RA, Cataldo AM. Free radicals, proteolysis and the degeneration of neurons in Alzheimer disease: How essential is the b-amyloid link? Neurobiol Aging 1994; 15:463-69.
  50. Nixon RA, Saito K‑I, Grynspan F, Griffin WR, Katayama S, Honda T, Mohan PS, Shea TB, Beermann ML. Calcium‑activated neutral proteinase (calpain) system in aging and Alzheimer disease. Ann N Y Acad Sci 1994; 747:77-91.
  51. Nixon RA. Neuronal degenerative mechanisms as clues to pathogenesis and treatment of Alzheimer's disease. Neurobiol Aging 1994; 15:S61-S65. 169.
  52. Nixon RA. The regulation of neurofilament protein dynamics by phosphorylation: Clues to neurofibrillary pathobiology. Brain Pathol 1993; 3:29-38.
  53. Nixon RA. Slow axonal transport. In: Current Opinion in Cell Biology 1992; 4:8-14.
  54. Nixon RA, Shea TB. Dynamics of neuronal intermediate filaments: A developmental perspective. In: Cell Motil Cytoskel 1992; 22:81-91.
  55. Nixon RA. Axonal transport of cytoskeletal proteins. In: Burgoyne RD, ed. The Neuronal Cytoskeleton. New York: Wiley‑Liss, Inc., 1991; 283-307.
  56. Nixon RA, Sihag RK. Neurofilament phosphorylation: A new look at regulation and function. Trends Neurosci 1991; 14:501-506.
  57. Pope A, Nixon RA. Proteases of human brain. In: Neurochem Res 1984; 9:291-323.
  58. Nixon RA. Proteolysis of neurofilaments. In: Marotta CA, ed. Neurofilaments. Minneapolis: University of Minnesota Press, 1983; 17-54
  59. Colacurcio DJ, Nixon RA. Disorders of lysosomal acididification-The emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Res Rev 2016 32:75-88.
  60. Klionsky DJ, Adbelmohsen K, Abe A, Adedin MJ, Abeliovich H, Bodi M, Jiang Y, Nixon RA, Nakano IR, Nakatogawa H Etal Guidekines for the use and interpretation of assays for monitoring autophagy (3rd Edition). Autophagy 201612(1):1-222 Click for abstract PDF
  61. Yuan A, Nixon RA. Specialized roles of neurofilament protein in synapses: Relevance to neuropsychiatric disorders. Brain Res Bull 2016 126(Pt3):334-346
  62. Yuan A, Rao MV, Veeranna, Nixon RA. Neurofilaments and Neurofilament Proteins in Health and Disease. Cold Spring Harb Perspect Biol 2017 Apr 3;9(4).
  63. Nixon RA. Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease. FASEB J 2017; 31(7):2729-2743.
  64. Colacurcio DJ, Pensalfini A, Jiang Y, Nixon RA. Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease. Free Radic Biol Med 2018 114:40-51.
  65. Lie PPY, Nixon RA. Lysosome trafficking and signaling in health and neurodegenerative diseases. Neurobiol Dis 2018 doi:10.1016/j.nbd.2018.05.015[Epub ahead of print]
  66. Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, Spedding M, Louis C, Martin OR, Millan MJ. Promoting the clerance of neurotoxic proteins in neurodegenerative disorders of aging. Nature Reviews 2018 doi:10.1038/nrd.2018.109

[Last updated 08.29.19]