Publications for Masuo Ohno, PhD

Requests for papers can be made by emailing Masuo Ohno.

Original Publications

  1. Ohno, M., Yamamoto, T., Araki, H., and Ueki, S. (1987). The effect of k-opioid agonist U-50,488H on wet-dog shaking behavior induced by hippocampal stimulation in rats. Psychopharmacology, 91, 189–192. PMID: 3107029. Click for abstract
  2. Ohno, M., Yamamoto, T., and Ueki, S. (1987). Clonidine attenuates wet-dog shaking induced by hippocampal stimulation in rats. Eur. J. Pharmacol., 137, 161–166. PMID: 3609139. Click for abstract
  3. Ohno, M., Yamamoto, T., and Ueki, S. (1987). Influences of electrical lesions of the dopaminergic system on morphine- and U-50,488H-induced analgesia in rats. Pharmacol. Biochem. Behav., 27, 457–461. PMID: 3659068. Click for abstract
  4. Watanabe, S., Ohta, H., Yamashita, K., Ohno, M., Tani, Y., Furuya, Y., and Ueki, S. (1987). Electroencephalographic (EEG) effect of quinupramine in the rabbit. Folia Pharmacol. Japon., 89, 339–354. (Abstract in English) PMID: 3623335. Click for abstract
  5. Yamamoto, T., Ohno, M., Takao, K., and Ueki, S. (1988). Anti-serotonin action in combination with noradrenaline-stimulating action is important for inhibiting muricide in midbrain raphe-lesioned rats. Neuropharmacology, 27, 123–127. PMID: 3352870. Click for abstract
  6. Watanabe, S., Ohta, H., Ohno, M., Tani, Y., Furuya, Y., Ueki, S., Man'no, K., and Sugihara, K. (1988). Electroencephalographic effects of the new antidepressant paroxetine in the rabbit. Arzneim.-Forsch./Drug Res., 38, 332–340. PMID: 2968081. Click for abstract
  7. Araki, H., Uchiyama, Y., Aihara, H., Yamamoto, T., Ohno, M., and Ueki, S. (1988). Inhibitory effect of apomorphine on hippocampal stimulation-induced "wet-dog shakes" in rats may be due to a stereotyped behavior. Arch. Int. Pharmacodyn. Ther., 292, 68–75. PMID: 3395175. Click for abstract
  8. Yamamoto, T., Ohno, M., and Ueki, S. (1988). A selective k-opioid agonist, U-50,488H, blocks the development of tolerance to morphine analgesia in rats. Eur. J. Pharmacol., 156, 173–176. PMID: 2850208. Click for abstract
  9. Ohno, M., Yamamoto, T., and Ueki, S. (1989) Effect of isofloxythepin, a novel neuroleptic, on hippocampal stimulation-induced wet-dog shaking in the rat. Japan. J. Pharmacol., 49, 21–26. HTML PDF
  10. Araki, H., Uchiyama-Tsuyuki, Y., Aihara, H., Yamamoto, T., Ohno, M., and Ueki, S. (1989) Effects of chronic administration of haloperidol, methamphetamine or cocaine on "wet-dog shakes" elicited by stimulation of the rat hippocampus. Arch. Int. Pharmacodyn. Ther., 297, 217–224. PMID: 2730237. Click for abstract
  11. Ohno, M., Yamamoto, T., and Ueki, S. (1989). Inhibitory effect of a selective kappa receptor agonist, U-50,488H, on methamphetamine-elicited ipsilateral circling behavior in rats with unilateral nigral lesions. Psychopharmacology, 97, 219–221. PMID: 2543013. Click for abstract
  12. Yatsugi, S., Yamamoto, T. Ohno, M., and Ueki, S. (1989). Effect of S-adenosyl-L-methionine on impairment of working memory induced in rats by cerebral ischemia and scopolamine. Eur. J. Pharmacol., 166, 231–239. PMID: 2792191. Click for abstract
  13. Yamamoto, T., Yatsugi, S., Ohno, M., and Ueki, S. (1989). Inhibition of mouse-killing behavior by S-adenosyl-L-methionine in midbrain raphe-lesioned and olfactory-bulbectomized rats. Pharmacol. Biochem. Behav., 34, 395–398. PMID: 2622996. Click for abstract
  14. Yamamoto, T., Shibata, S., Shimazoe, T., Iwasaki, K., Ohno, M., Minamoto, Y., Furuya, Y., Miyamoto, K., Watanabe, S., Ueki, S., Man'no, K., and Sugihara, K. (1989). Behavioral pharmacological properties of the novel antidepressant paroxetine, a selective 5-HT uptake inhibitor. Folia Pharmacol. Japon., 94, 189–206. (Abstract in English) PMID: 2530142. Click for abstract
  15. Yamamoto, T., Yatsugi, S., Ohno, M., Furuya, Y., Kitajima, I., and Ueki, S. (1990). Minaprine improves impairment of working memory induced by scopolamine and cerebral ischemia. Psychopharmacology, 100, 316–322. PMID: 2315427. Click for abstract
  16. Ohno, M., Yamamoto, T., Kitajima, I., and Ueki, S. (1990). WEB 1881 FU ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task. Japan. J. Pharmacol., 54, 53–60. HTML PDF
  17. Ohno, M., Yamamoto, T., and Ueki, S. (1991). Effect of the k-receptor agonist, U-50,488H, on cerebral ischemia-induced impairment of working memory assessed in rats by a three-panel runway task. Eur. J. Pharmacol., 193, 357–361. PMID: 1647321. Click for abstract
  18. Yamamoto, T., Shibata, S., Teshima, K., Inoue, Y., Ushio, M., Tominaga, K., Ohno, M., Watanabe, S., and Ueki, S. (1991). Behavioral pharmacological and electroencephalographic effects of the 5-HT1A partial agonist ipsapirone. Folia Pharmacol. Japon., 98, 41–52. (Abstract in English) PMID: 1679740. Click for abstract
  19. Ohno, M., Yamamoto, T., and Watanabe, S. (1991). Blockade of 5-HT2 receptors protects against impairment of working memory following transient forebrain ischemia in the rat. Neurosci. Lett., 129, 185–188. PMID: 1745398. Click for abstract
  20. Ohno, M., Yamamoto, T., and Watanabe, S. (1991). Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia. Eur. J. Pharmacol., 204, 113–116. PMID: 1804660. Click for abstract
  21. Ohno, M., Yamamoto, T., and Ueki, S. (1992). Analgesic and discriminative stimulus properties of U-62,066E, the selective kappa-opioid receptor agonist, in the rat. Psychopharmacology, 106, 31–38. PMID: 1346721. Click for abstract
  22. Kitajima, I., Yamamoto, T., Ohno, M., and Ueki, S. (1992). Working and reference memory in rats in the three-panel runway task following dorsal hippocampal lesions. Jpn. J. Pharmacol., 58, 175–183. HTML PDF
  23. Ohno, M., Yamamoto, T., Ueki, S., and Watanabe, S. (1992). Protection by N-methyl-D-aspartate receptor antagonists against impairment of working memory in rats following transient cerebral ischemia. Neurosci. Lett., 138, 1–4. PMID: 1407646. Click for abstract
  24. Yamamoto, T., Ohno, M., Yatsugi, S., Fujikawa, Y., and Ueki, S. (1992). Nootropic candidates inhibit head-twitches induced by mescaline in mice. Jpn. J. Pharmacol., 59, 419–421. HTML PDF
  25. Ohno, M., Yamamoto, T., and Watanabe, S. (1992). Intrahippocampal injections of benzodiazepine and muscimol impair working memory but not reference memory of rats in the three-panel runway task. Eur. J. Pharmacol., 219, 245–251. PMID: 1330607. Click for abstract
  26. Ohno, M., Yamamoto, T., and Watanabe, S. (1992). Involvement of cholinergic mechanisms in impairment of working memory in rats following basolateral amygdaloid lesions. Neuropharmacology, 31, 915–922. PMID: 1436398. Click for abstract
  27. Ohno, M., Yamamoto, T., and Watanabe, S. (1992). Effects of intrahippocampal injections of N-methyl-D-aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway task. J. Pharmacol. Exp. Ther., 263, 943–950. PMID: 1361577. Click for abstract
  28. Yamamoto, T., Ohno, M., Kitajima, I., Yatsugi, S., and Ueki, S. (1993). Ameliorative effects of the centrally active cholinesterase inhibitor, NIK-247, on impairment of working memory in rats. Physiol. Behav., 53, 5–10. PMID: 8434069. Click for abstract
  29. Ohno, M., Yamamoto, T., and Watanabe, S. (1993). Working memory deficits induced by intrahippocampal administration of 8-OH-DPAT, a 5-HT1A receptor agonist, in the rat. Eur. J. Pharmacol., 234, 29–34. PMID: 8472759. Click for abstract
  30. Yamamoto, T., Ohno, M., Sugimachi, K., and Ueki, S. (1993). Discriminative stimulus properties of NIK-247 and tetrahydroaminoacridine, centrally active cholinesterase inhibitors, in rats. Pharmacol. Biochem. Behav., 44, 769–775. PMID: 8469688. Click for abstract
  31. Ohno, M., Yamamoto, T., and Watanabe, S. (1993). Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats. Pharmacol. Biochem. Behav., 45, 89–93. PMID: 8516378. Click for abstract
  32. Ohno, M., Shibata, S., Yamamoto, T., and Watanabe, S. (1993). Working memory deficits following muscarinic blockade combined with depletion of brain somatostatin in rats. Brain Res., 610, 348–353. PMID: 8100474. Click for abstract
  33. Ohno, M., Yamamoto, T., Kobayashi, M., and Watanabe, S. (1993). Impairment of working memory induced by scopolamine in rats with noradrenergic DSP-4 lesions. Eur. J. Pharmacol., 238, 117–120. PMID: 8405074. Click for abstract
  34. Ohno, M., Yamamoto, T., and Watanabe, S. (1993). Amygdaloid NMDA and muscarinic receptors involved in working memory performance of rats. Physiol. Behav., 54, 993–997. PMID: 8248394. Click for abstract
  35. Ohno, M., Yamamoto, T., and Watanabe, S. (1993). Deficits in working memory following inhibition of hippocampal nitric oxide synthesis in the rat. Brain Res., 632, 36–40. PMID: 7511980. Click for abstract
  36. Ohno, M., Yamamoto, T., and Watanabe, S. (1994). Intrahippocampal administration of the NO synthase inhibitor L-NAME prevents working memory deficits in rats exposed to transient cerebral ischemia. Brain Res., 634, 173–177. PMID: 7512427 Click for abstract
  37. Ohno, M., Yamamoto, T., and Watanabe, S. (1994). Intrahippocampal administration of a glycine site antagonist impairs working memory performance of rats. Eur. J. Pharmacol., 253, 183–187. PMID: 8013546. Click for abstract
  38. Ohno, M., Yamamoto, T., and Watanabe, S. (1994). Blockade of hippocampal M1 muscarinic receptors impairs working memory performance of rats. Brain Res., 650, 260–266. PMID: 7953691. Click for abstract
  39. Ohno, M., Yoshida, H., and Watanabe, S. (1994). NMDA receptor-mediated expression of Fos protein in the rat striatum following methamphetamine administration: relation to behavioral sensitization. Brain Res., 665, 135–140. PMID: 7882006. Click for abstract
  40. Ohno, M., Kikusui, M., Yoshimatsu, A., Yamamoto, T., and Watanabe, S. (1994). Somatostatin alleviates impairment of working memory induced by hippocampal muscarinic M1 receptor blockade in rats. Eur. J. Pharmacol., 271, 557–560. PMID: 7705459. Click for abstract
  41. Ohno, M., and Watanabe, S. (1995). Nitric oxide synthase inhibitors block behavioral sensitization to methamphetamine in mice. Eur. J. Pharmacol., 275, 39–44. PMID: 7539765. Click for abstract
  42. Ohno, M., and Watanabe, S. (1995). Intrahippocampal administration of (+)-SKF 10,047, a s ligand, reverses MK-801-induced impairment of working memory in rats. Brain Res., 684, 237–242. PMID: 7583231. Click for abstract
  43. Kobayashi, M., Ohno, M., Yamamoto, T., and Watanabe, S. (1995). Concurrent blockade of b-adrenergic and muscarinic receptors disrupts working memory but not reference memory in rats. Physiol. Behav., 58, 307–314. PMID: 7568434. Click for abstract
  44. Yoshida, H., Ohno, M., and Watanabe, S. (1995). Roles of dopamine D1 receptors in striatal Fos protein induction associated with methamphetamine behavioral sensitization in rats. Brain Res. Bull., 38, 393–397. PMID: 8535862. Click for abstract
  45. Ohno, M., and Watanabe, S. (1995). Persistent increase in dopamine release following activation of metabotropic glutamate receptors in the rat nucleus accumbens. Neurosci. Lett., 200, 113–116. PMID: 8614557. Click for abstract
  46. Ohno, M., Arai, I., and Watanabe, S. (1995). N-Methyl-D-aspartate stimulates dopamine release through nitric oxide formation in the nucleus accumbens of rats. Brain Res., 699, 332–335. PMID: 8616639. Click for abstract
  47. Ohno, M., and Watanabe, S. (1996). Concurrent blockade of hippocampal metabotropic glutamate and N-methyl-D-aspartate receptors disrupts working memory in the rat. Neuroscience, 70, 303–311. PMID: 8848141. Click for abstract
  48. Miyamoto, A., Yamamoto, T., Ohno, M., Watanabe, S., Tanaka, H., Morimoto, S., and Shoyama, Y. (1996). Roles of dopamine D1 receptors in D9-tetrahydrocannabinol-induced expression of Fos protein in the rat brain. Brain Res., 710, 234–240. PMID: 8963664. Click for abstract
  49. Ohno, M., and Watanabe, S. (1996) Ischemic tolerance to memory impairment associated with hippocampal neuronal damage after transient cerebral ischemia in rats. Brain Res. Bull., 40, 229–236. PMID: 8736585. Click for abstract
  50. Ohno, M., Yoshimatsu, A., Kobayashi, M., and Watanabe, S. (1996). b-Adrenergic dysfunction exacerbates impairment of working memory induced by hippocampal NMDA receptor blockade in rats. Eur. J. Pharmacol., 307, 21–26. PMID: 8831099. Click for abstract
  51. Ohno, M., and Watanabe, S. (1996) Interactive processing between glutamatergic and cholinergic systems involved in inhibitory avoidance learning of rats. Eur. J. Pharmacol., 312, 145–147. PMID: 8894588. Click for abstract
  52. Ohno, M., and Watanabe, S. (1996). Blockade of 5-HT1A receptors compensates loss of hippocampal cholinergic neurotransmission involved in working memory of rats. Brain Res., 736, 180–188. PMID: 8930323. Click for abstract
  53. Ohno, M., Kishi, A., and Watanabe, S. (1996). Effect of cholinergic activation by physostigmine on working memory failure caused in rats by pharmacological manipulation of hippocampal glutamatergic and 5-HTergic neurotransmission. Neurosci. Lett., 217, 21–24. PMID: 8905730. Click for abstract
  54. Shishido, Y., Furushiro, M., Tanabe, S., Nishiyama, S., Hashimoto, S., Ohno, M., Yamamoto, T., and Watanabe, S. (1996). ZTTA, a postproline cleaving enzyme inhibitor, improves cerebral ischemia-induced deficits in a three-panel runway task in rats. Pharmacol. Biochem. Behav., 55, 333–338. PMID: 8951974. Click for abstract
  55. Ohno, M., and Watanabe, S. (1996). Working memory failure by stimulation of hippocampal adenosine A1 receptors in rats. Neuroreport, 7, 3013–3016. PMID: 9116230. Click for abstract
  56. Ohno, M., and Watanabe, S. (1996). D-Cycloserine, a glycine site agonist, reverses working memory failure by hippocampal muscarinic blockade in rats. Eur. J. Pharmacol., 318, 267–271. PMID: 9016914. Click for abstract
  57. Ohno, M., Yoshimatsu, A., Kobayashi, M., and Watanabe, S. (1997). Noradrenergic DSP-4 lesions aggravate impairment of working memory produced by hippocampal muscarinic blockade in rats. Pharmacol. Biochem. Behav., 57, 257–261. PMID: 9164580. Click for abstract
  58. Ohno, M., Kobayashi, M., Kishi, A., and Watanabe, S. (1997). Working memory failure by combined blockade of muscarinic and b-adrenergic transmission in the rat hippocampus. Neuroreport, 8, 1571–1575. PMID: 9189894. Click for abstract
  59. Ohno, M., and Watanabe, S. (1997). Differential effects of 5-HT3 receptor antagonism on working memory failure due to deficiency of hippocampal cholinergic and glutamatergic transmission in rats. Brain Res., 762, 211–215. PMID: 9262175. Click for abstract
  60. Miyamoto, A., Yamamoto, T., Ohno, M., and Watanabe, S. (1997). Desensitization of Fos protein induction in rat striatum and nucleus accumbens following repeated administration of D9-tetrahydrocannabinol. Brain Res., 763, 137–140. PMID: 9272839. Click for abstract
  61. Kobayashi, M., Ohno, M., Shibata, S., Yamamoto, T., and Watanabe, S. (1997). Concurrent blockade of b-adrenergic and muscarinic receptors suppresses synergistically long-term potentiation of population spikes in the rat hippocampal CA1 region. Brain Res., 777, 242–246. PMID: 9449436. Click for abstract
  62. Ohno, M., and Watanabe, S. (1998). Enhanced N-methyl-D-aspartate function reverses working memory failure induced by blockade of group I metabotropic glutamate receptors in the rat hippocampus. Neurosci. Lett., 240, 37–40. PMID: 9488169 Click for abstract
  63. Nakazato, E., Ohno, M., and Watanabe, S. (1998). MK-801 reverses Fos expression induced by the full dopamine D1 receptor agonist SKF-82958 in the rat striatum. Eur. J. Pharmacol., 342, 209–212. PMID: 9548387. Click for abstract
  64. Kishi, A., Ohno, M., and Watanabe, S. (1998). Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats. Brain Res., 793, 311–314. PMID: 9630697. Click for abstract
  65. Kishi, A., Ohno, M., and Watanabe, S. (1998). Concurrent activation of hippocampal glycine and polyamine sites of the N-methyl-D-aspartate receptor synergistically reverses working memory deficits in rats. Neurosci. Lett., 257, 131–134. PMID: 9870337. Click for abstract
  66. Nakazato, E., Yamamoto, T., Ohno, M., and Watanabe, S. (2000). Cholinergic and glutamatergic activation reverses working memory failure by hippocampal histamine H1 receptor blockade in rats. Life Sci., 67, 1139–1147. PMID: 10954048. Click for abstract
  67. Frankland, P.W., O'Brien, C., Ohno, M., Kirkwood, A., and Silva, A.J. (2001). a-CaMKII-dependent plasticity in the cortex is required for permanent memory. Nature, 411, 309–313. PMID: 11357133.This article was featured by “news and views” in Nature 411, 248–249, 2001. Click for abstract
  68. Ohno, M., Frankland, P.W., Chen, A.P., Costa, R.M., and Silva, A.J. (2001). Inducible, pharmacogenetic approaches to the study of learning and memory. Nat. Neurosci., 4, 1238–1243. PMID: 11713472. This article was featured by “Research Update” in TINS 25, 277–279, 2002. Click for abstract
  69. Costa, R.M., Fedorov, N.B., Kogan, J.H., Murphy, G.G., Stern, J., Ohno, M., Kucherlapati, R., Jacks, T., and Silva, A.J. (2002). Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 415, 526–530. PMID: 11793011. Click for abstract
  70. Ohno, M., Frankland, P.W., and Silva, A.J. (2002). A pharmacogenetic inducible approach to the study of NMDA/aCaMKII signaling in synaptic plasticity. Curr. Biol., 12, 654–656. PMID: 11967152. Click for abstract
  71. Ohno, M., Sametsky, E.A., Younkin, L.H., Oakley, H., Younkin, S.G., Citron, M., Vassar, R., and Disterhoft, J.F. (2004). BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer’s disease. Neuron, 41, 27–33.PMID: 14715132. This article was featured by “news and views in brief” in Nature 427, 210, 2004. Click for abstract
  72. Murphy, G.G., Fedorov, N.B., Giese, K.P., Ohno, M., Friedman, E., Chen, R., and Silva, A.J. (2004). Increased neuronal excitability, synaptic plasticity, and learning in aged Kvb1.1 knockout mice. Curr. Biol., 14, 1907–1915. PMID: 15530391. Click for abstract
  73. Ohno, M., Tseng, W., Silva, A.J., and Disterhoft, J.F. (2005). Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of aCaMKII in mice. Learn. Mem., 12, 211–215. HTML PDF
  74. Chen, A.P., Ohno, M., Giese, K.P., Kühn, R., Chen, R.L., and Silva, A.J. (2006). Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J. Neurosci. Res., 83, 28–38. PMID: 16342120. Click for abstract
  75. Ohno, M., Chang, L., Tseng, W., Oakley, H., Citron, M., Klein, W.L., Vassar, R., and Disterhoft, J.F. (2006). Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. Eur. J. Neurosci., 23, 251–260. PMID: 16420434. Click for abstract
  76. Ohno, M., Sametsky, E.A., Silva, A.J., and Disterhoft, J.F. (2006). Differential effects of aCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability. Eur. J. Neurosci., 23, 2235–2240. PMID: 16630070. Click for abstract
  77. Oakley, H., Cole, S.L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., Berry, R., and Vassar, R. (2006). Intraneuronal b-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J. Neurosci., 26, 10129–10140. HTML PDF
  78. Ohno, M., Cole, S.L., Yasvoina, M., Zhao, J., Citron, M., Berry, R., Disterhoft, J.F., and Vassar, R. (2007). BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice. Neurobiol. Dis., 26, 134–145. HTML PDF
  79. Kimura, R., Silva, A.J., and Ohno, M. (2008). Autophosphorylation of aCaMKII is differentially involved in new learning and unlearning mechanisms of memory extinction. Learn. Mem., 15, 837–843. HTML PDF
  80. Kimura, R., and Ohno, M. (2009). Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model. Neurobiol. Dis., 33, 229–235. HTML PDF
  81. Sametsky, E.A., Disterhoft, J.F., and Ohno, M. (2009). Autophosphorylation of aCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation. Neurobiol. Learn. Mem., 92, 120–123. PMID: 19245842. Click for abstract
  82. Ohno, M. (2009). Failures to reconsolidate memory in a mouse model of Alzheimer’s disease. Neurobiol. Learn. Mem., 92, 455–459. HTML PDF
  83. Devi, L., and Ohno, M. (2010). Genetic reductions of b-site amyloid precursor protein-cleaving enzyme 1 and amyloid-b ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer’s disease model mice. Eur. J. Neurosci., 31, 110–118. HTML PDF
  84. Kimura, R., Devi, L., and Ohno, M. (2010). Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer’s disease transgenic mice. J. Neurochem., 113, 248–261. HTML PDF
  85. Devi, L., and Ohno, M. (2010). Phospho-eIF2a level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice. PLoS One, 5, e12974. HTML PDF
  86. Devi, L., Alldred, M.J., Ginsberg, S.D., and Ohno, M. (2010). Sex- and brain region-specific acceleration of b-amyloidogenesis following behavioral stress in a mouse model of Alzheimer’s disease. Mol. Brain, 3, 34. HTML PDF
  87. Yang, D.-S., Stavrides, P., Mohan, P.S., Kaushik, S., Kumar, A., Ohno, M., Schmidt, S.D., Wesson, D., Bandyopadhyay, U., Jiang, Y., Pawlik, M., Peterhoff, C.M., Yang, A.J., Wilson, D.A., St George-Hyslop, P., Westaway, D., Mathews, P.M., Levy, E., Cuervo, A.M., and Nixon, R.A. (2011). Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain, 134, 258–277. HTML PDF
  88. Devi, L., and Ohno, M. (2011). 7,8-Dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer’s disease. Neuropsychopharmacology, 37(2): 434-44. doi:10.1038/npp.2011.191. PMID: 21900882. PMCID:PMC3242305 Click for abstract PDF
  89. Devi, L., and Ohno, M. (2012). Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer’s disease transgenic mice. Neurobiol. Dis., 45, 417–424. PMID: 21933711 PMCID:PMC3225635 Click for abstract PDF
  90. Devi L, Alldred MJ, Ginsberg SD, Ohno M. (2012). Mechanisms underlying insulin deficiency-induced acceleration of beta-amyloidosis in a mouse model of Alzheimer's disease. PLoS One. 7(3):e32792. PMID: 22403710 PMCID:PMC3293895 HTML PDF
  91. Devi L, Ohno M. Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer's disease in mice. Neurobiol Learn Mem, 2013, 102:7-11. PMID:23416036 PMCID: In Process Click for abstract
  92. Devi L, Ohno M. Mechanisms that lessen benefits of beta-secretase reduction in a mouse model of Alzheimer's disease. Transl Psychiatry, 2013, 3:e284. PMID:23880880 PMCID:PMC3731791 Click for abstract PDF
  93. Devi L, Ohno M. Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease. PLoS One, 2013, 8(10):e77335. PMID: 2414697 PMCID: PMC3795630 Click for abstract PDF
  94. Rao M, McBrayer MK, Campbell J, Kumar A, Hashim A, Sershen H, Stavrides PH, Ohno M, Hutton M, Nixon RA. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in Tau P301L mice. J Neurosci, 2014, 34(28):9222-34. PMC4087203 [Available 2015/1/9] Click for abstract
  95. Kaur G, Sharma A, Xu W, Gerum S, Alldred MJ, Subbanna S, Basavarajappa BS, Pawlik M, Ohno M, Ginsberg SD, Wilson DA, Guilfoyle DN, Levy E. Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down's syndrome. J Neurosci, 2014;34(15):5099-106. PMCID: PMC3983795 [Available on 10/9/2014] Click for abstract
  96. Devi L, Ohno M. PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease. Neurobiol Aging, 2014;35(10):2272-81. Click for abstract

Reviews, Books, and Book Chapters

  1. Yamamoto, T., and Ohno, M. (1995). Anxiety and depression: from standpoints of animal behavioral sciences. In S. Nomura and K. Nakazawa (Eds.), Biology of Anxiety and Depression, Biol. Psychiatry, Vol.10, pp.89–119. (in Japanese) [no abstract available]
  2. Watanabe, S., and Ohno, M. (1996). Pharmacological study on neural mechanisms underlying working memory in the hippocampus of rats. In K. Ishikawa, J.L. McGaugh and H. Sakata (Eds.), Brain Processes and Memory, Elsevier, Amsterdam, pp.3–13. [no abstract available]
  3. Yamamoto, T., and Ohno, M. (1996). Pharmacological application of a three-panel runway task to elucidate learning and memory in rats. In K. Onodera (Ed.), Advances in Neurobehavioral Pharmacology, Meth. Find. Exp. Clin. Pharmacol., Vol.18 (Supple. A), pp.5–15. [no abstract available]
  4. Ohno, M., and Watanabe, S. (1997). Glutamate receptors. Life Sci., 48, 330–335. (in Japanese) [no abstract available]
  5. Ohno, M., Frankland, P.W., and Silva, A.J. (2002). Roles of CaMKII as a key molecular component of cortical permanent memory. Cell Technology, 21, 1017–1021. (in Japanese) [no abstract available]
  6. Frankland, P.W., Ohno, M., Takahashi, E., Chen, A.P., Costa, R.M., Kushner, S.A., and Silva, A.J. (2003). Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory. Neuroscientist, 9, 104–109. PMID: 12708614. Click for abstract
  7. Disterhoft, J.F., Wu, W.W., and Ohno, M. (2004). Biophysical alterations of hippocampal pyramidal neurons in learning, ageing and Alzheimer's disease. Ageing Res. Rev., 3, 383–406. PMID: 15541708. Click for abstract
  8. Ohno, M. (2006). Genetic and pharmacological basis for therapeutic inhibition of b- and g-secretases in mouse models of Alzheimer’s memory deficits. Rev. Neurosci., 17, 429–454. PMID: 17139843. Click for abstract
  9. Ohno, M., and Disterhoft, J.F. (2007). Alzheimer’s disease therapies: updates on genetic and pharmacological manipulations of b-secretase. In M.-K. Sun (Ed.), Research Progress in Alzheimer’s Disease and Dementia, Vol.1, Nova Science Publishers, New York, pp.39–59. [no abstract available]
  10. Ohno, M. (2008). b-Secretase as a prime therapeutic target for Alzheimer’s disease: a perspective from mouse model studies. In W. Araki (Ed.), Recent Advances in the Biology of Secretases, Key Proteases in Alzheimer’s Disease, Research Signpost, Kerala, pp.1–25. [no abstract available]
  11. Ohno, M. (2012). Impaired memory mechanisms in mouse models of Alzheimer's disease. In K.P. Giese (Ed.), Memory Mechanisms in Health and Diseases: Mechanistic Basis of Memory, World Scientific Publishing, London, pp.343-379. [no abstract available]
  12. Ohno M. Roles of eIF2α kinases in the pathogenesis of Alzheimer's disease. Front Mol Neurosci. 2014;7:22. eCollection 2014. Review. Click for abstract PMID:24795560 PMCID:PMC3997008 PDF

[last updated 11.14.14]