My Bibliography

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D'Acunzo P, Ungania JM, Kim Y, Barreto BR, DeRosa S, Pawlik M, Canals-Baker S, Erdjument-Bromage H, Hashim A, Goulbourne CN, Neubert TA, Saito M, Sershen H, Levy E. Cocaine perturbs mitovesicle biology in the brain. J Extracell Vesicles. 2023 Jan;12(1):e12301. doi: 10.1002/jev2.12301. PubMed PMID: 36691887; PubMed Central PMCID: PMC9871795.

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Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, Stavrides PH, Darji S, Malampati S, Peddy J, Bleiwas C, Pawlik M, Pensalfini A, Yang DS, Subbanna S, Basavarajappa BS, Smiley JF, Gardner A, Blackburn K, Chu HM, Prins ND, Teunissen CE, Harrison JE, Scheltens P, Nixon RA. Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration. Nat Commun. 2022 Sep 21;13(1):5308. doi: 10.1038/s41467-022-32944-3. PubMed PMID: 36130946; PubMed Central PMCID: PMC9492778.

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Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA. Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nat Neurosci. 2022 Jun;25(6):688-701. doi: 10.1038/s41593-022-01084-8. Epub 2022 Jun 2. PubMed PMID: 35654956; PubMed Central PMCID: PMC9174056.

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D'Acunzo P, Pérez-González R, Kim Y, Hargash T, Miller C, Alldred MJ, Erdjument-Bromage H, Penikalapati SC, Pawlik M, Saito M, Saito M, Ginsberg SD, Neubert TA, Goulbourne CN, Levy E. Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome. Sci Adv. 2021 Feb;7(7). doi: 10.1126/sciadv.abe5085. Print 2021 Feb. PubMed PMID: 33579698; PubMed Central PMCID: PMC7880603.

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Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell Rep. 2020 Nov 24;33(8):108420. doi: 10.1016/j.celrep.2020.108420. PubMed PMID: 33238112; PubMed Central PMCID: PMC7714675.

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Pérez-González R, Gauthier SA, Sharma A, Miller C, Pawlik M, Kaur G, Kim Y, Levy E. A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients. Neurobiol Aging. 2019 Dec;84:26-32. doi: 10.1016/j.neurobiolaging.2019.07.016. Epub 2019 Aug 1. PubMed PMID: 31479861; PubMed Central PMCID: PMC6960325.

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D'Acunzo P, Hargash T, Pawlik M, Goulbourne CN, Pérez-González R, Levy E. Enhanced generation of intraluminal vesicles in neuronal late endosomes in the brain of a Down syndrome mouse model with endosomal dysfunction. Dev Neurobiol. 2019 Jul;79(7):656-663. doi: 10.1002/dneu.22708. Epub 2019 Aug 1. PubMed PMID: 31278881; PubMed Central PMCID: PMC6894426.

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Pérez-González R, Sahoo S, Gauthier SA, Kim Y, Li M, Kumar A, Pawlik M, Benussi L, Ghidoni R, Levy E. Neuroprotection mediated by cystatin C-loaded extracellular vesicles. Sci Rep. 2019 Jul 31;9(1):11104. doi: 10.1038/s41598-019-47524-7. PubMed PMID: 31367000; PubMed Central PMCID: PMC6668451.

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Kaur G, Gauthier SA, Perez-Gonzalez R, Pawlik M, Singh AB, Cosby B, Mohan PS, Smiley JF, Levy E. Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome. Neurobiol Dis. 2018 Dec;120:165-173. doi: 10.1016/j.nbd.2018.08.025. Epub 2018 Sep 1. PubMed PMID: 30176349; PubMed Central PMCID: PMC6309243.

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Gauthier SA, Pérez-González R, Sharma A, Huang FK, Alldred MJ, Pawlik M, Kaur G, Ginsberg SD, Neubert TA, Levy E. Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities. Acta Neuropathol Commun. 2017 Aug 29;5(1):65. doi: 10.1186/s40478-017-0466-0. PubMed PMID: 28851452; PubMed Central PMCID: PMC5576289.

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Kaur G, Pawlik M, Gandy SE, Ehrlich ME, Smiley JF, Levy E. Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein. Mol Psychiatry. 2017 Jul;22(7):981-989. doi: 10.1038/mp.2016.189. Epub 2016 Oct 25. PubMed PMID: 27777419; PubMed Central PMCID: PMC5405008.

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Yang DS, Stavrides P, Kumar A, Jiang Y, Mohan PS, Ohno M, Dobrenis K, Davidson CD, Saito M, Pawlik M, Huo C, Walkley SU, Nixon RA. Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice. Hum Mol Genet. 2017 Mar 1;26(5):843-859. doi: 10.1093/hmg/ddx001. PubMed PMID: 28062666; PubMed Central PMCID: PMC6075207.

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Li W, Sultana N, Siraj N, Ward LJ, Pawlik M, Levy E, Jovinge S, Bengtsson E, Yuan XM. Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis. J Cell Mol Med. 2016 Sep;20(9):1664-72. doi: 10.1111/jcmm.12859. Epub 2016 Apr 14. PubMed PMID: 27079462; PubMed Central PMCID: PMC4988293.

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Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiol Aging. 2016 Mar;39:90-8. doi: 10.1016/j.neurobiolaging.2015.11.013. Epub 2015 Dec 2. PubMed PMID: 26923405; PubMed Central PMCID: PMC4773919.

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Yang DS, Stavrides P, Saito M, Kumar A, Rodriguez-Navarro JA, Pawlik M, Huo C, Walkley SU, Saito M, Cuervo AM, Nixon RA. Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits. Brain. 2014 Dec;137(Pt 12):3300-18. doi: 10.1093/brain/awu278. Epub 2014 Sep 29. PubMed PMID: 25270989; PubMed Central PMCID: PMC4240291.

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Kaur G, Sharma A, Xu W, Gerum S, Alldred MJ, Subbanna S, Basavarajappa BS, Pawlik M, Ohno M, Ginsberg SD, Wilson DA, Guilfoyle DN, Levy E. Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down's syndrome. J Neurosci. 2014 Apr 9;34(15):5099-106. doi: 10.1523/JNEUROSCI.5338-13.2014. PubMed PMID: 24719089; PubMed Central PMCID: PMC3983795.

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Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy. 2011 Jul;7(7):788-9. doi: 10.4161/auto.7.7.15596. Epub 2011 Jul 1. PubMed PMID: 21464620; PubMed Central PMCID: PMC3359468.

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Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain. 2011 Jan;134(Pt 1):258-77. doi: 10.1093/brain/awq341. PubMed PMID: 21186265; PubMed Central PMCID: PMC3009842.

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Kaur G, Mohan P, Pawlik M, DeRosa S, Fajiculay J, Che S, Grubb A, Ginsberg SD, Nixon RA, Levy E. Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy. Am J Pathol. 2010 Nov;177(5):2256-67. doi: 10.2353/ajpath.2010.100461. Epub 2010 Oct 1. PubMed PMID: 20889561; PubMed Central PMCID: PMC2966785.

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Tizon B, Sahoo S, Yu H, Gauthier S, Kumar AR, Mohan P, Figliola M, Pawlik M, Grubb A, Uchiyama Y, Bandyopadhyay U, Cuervo AM, Nixon RA, Levy E. Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PLoS One. 2010 Mar 23;5(3):e9819. doi: 10.1371/journal.pone.0009819. PubMed PMID: 20352108; PubMed Central PMCID: PMC2843718.

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Yang DS, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M, Levy E, Cataldo AM, Nixon RA. Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol. 2008 Sep;173(3):665-81. doi: 10.2353/ajpath.2008.071176. Epub 2008 Aug 7. PubMed PMID: 18688038; PubMed Central PMCID: PMC2527090.

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Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet. 2007 Dec;39(12):1440-2. doi: 10.1038/ng.2007.29. Epub 2007 Nov 18. PubMed PMID: 18026100.

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Pawlik M, Otero DA, Park M, Fischer WH, Levy E, Saitoh T. Proteins that bind to the RERMS region of beta amyloid precursor protein. Biochem Biophys Res Commun. 2007 Apr 20;355(4):907-12. doi: 10.1016/j.bbrc.2007.02.047. Epub 2007 Feb 20. PubMed PMID: 17335780; PubMed Central PMCID: PMC1896148.

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Prelli F, Pawlik M, Frangione B, Levy E. Purification of human wild-type or variant cystatin C from conditioned media of transfected cells. Methods Mol Biol. 2005;299:221-6. doi: 10.1385/1-59259-874-9:221. PubMed PMID: 15980605.

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Sastre M, Calero M, Pawlik M, Mathews PM, Kumar A, Danilov V, Schmidt SD, Nixon RA, Frangione B, Levy E. Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation. Neurobiol Aging. 2004 Sep;25(8):1033-43. doi: 10.1016/j.neurobiolaging.2003.11.006. PubMed PMID: 15212828.

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Pawlik M, Sastre M, Calero M, Mathews PM, Schmidt SD, Nixon RA, Levy E. Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide. J Mol Neurosci. 2004;22(1-2):13-8. doi: 10.1385/JMN:22:1-2:13. PubMed PMID: 14742906.

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Calero M, Pawlik M, Soto C, Castaño EM, Sigurdsson EM, Kumar A, Gallo G, Frangione B, Levy E. Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. J Neurochem. 2001 Apr;77(2):628-37. doi: 10.1046/j.1471-4159.2001.00256.x. PubMed PMID: 11299325.

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Pawlik M, Fuchs E, Walker LC, Levy E. Primate-like amyloid-beta sequence but no cerebral amyloidosis in aged tree shrews. Neurobiol Aging. 1999 Jan-Feb;20(1):47-51. doi: 10.1016/s0197-4580(99)00017-2. PubMed PMID: 10466892.

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Saitoh T, Jin L, Roch J, Pawlik M. Induction of Signal Transducing Pathways by SPP binding to the Cell Surface Receptor. In: Iqbak K, Mortimer J, Weinblad B, Wisniewski H, editors. Research Advances in Alzheimer's Disease and Related Disorders New York: Wiley; 1995. p.693 - 699.

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May T, Pawlik M, Rommelspacher H. [3H]harman binding experiments. II: Regional and subcellular distribution of specific [3H]harman binding and monoamine oxidase subtypes A and B activity in marmoset and rat. J Neurochem. 1991 Feb;56(2):500-8. doi: 10.1111/j.1471-4159.1991.tb08178.x. PubMed PMID: 1988553.

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May T, Rommelspacher H, Pawlik M. [3H]harman binding experiments. I: A reversible and selective radioligand for monoamine oxidase subtype A in the CNS of the rat. J Neurochem. 1991 Feb;56(2):490-9. doi: 10.1111/j.1471-4159.1991.tb08177.x. PubMed PMID: 1988552.

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Pawlik M, Kaulen P, Baumgarten HG, Rommelspacher H. Quantitative autoradiography of [3H]norharman [( 3H]beta-carboline) binding sites in the rat brain. J Chem Neuroanat. 1990 Jan-Feb;3(1):19-24. PubMed PMID: 2156525.

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Pawlik M, Rommelspacher H. Demonstration of a distinct class of high-affinity binding sites for [3H]norharman [( 3H]beta-carboline) in the rat brain. Eur J Pharmacol. 1988 Mar 1;147(2):163-71. doi: 10.1016/0014-2999(88)90775-3. PubMed PMID: 3366173.