Publications for Mala Rao, PhD

Requests for papers can be made by emailing Mala Rao.

Original Publications

  1. Rao, M.V., Rangarajan, P.N. and Padmanaban, G. Dexamethasone negatively regulates phenobarbitone activated transcription but synergistically enhances cytoplasmic levels of Cytochrome P-450 b/e messenger RNA. J. Biol. Chem. 1990; 265: 5617-22. PMID: 2318828 Click for abstract
  2. Upadhya, P., Rao, M.V., Venkateswar, V., Rangarajan, P.N. and Padmanaban, G. Identification and functional characterization of a cis-acting positive DNA element regulating CYP2BI/B2 gene transcription in rat liver.  Nucleic Acids Res. 1992; 20; 557-62. PMID: 1741290 Full text available:
  3. Kim, M., Rao, M.V., Tweardy, D.J., Prakash., Galili, U. and Gorelick, E.  Lectin induced apoptosis of tumor cells.  Glycobiology 1993; 3: 447-53. PMID: 8286857 Click for abstract
  4. Ram, N., Rao, M.V., Prabhu, L., Nirodi, C.S., Vatsala, P.G. and Padmanaban, G. Characterization of a negative cis-acting DNA element regulating transcription of CYP2B I/B2 gene in rat liver.  Arch. Biochem. Biophys. 1995; 317: 39-45. PMID: 7872801 Click for abstract
  5. Muller, J., Khan, A.S., Li, M. Rao, M.V. Hearing, V.J., and Gorelik, E. Phenotypic changes and loss of melanoma-specific endogenous C-type retroviruses in BL6 melanoma cells transfected with the H-2Kb gene.  Melanoma Res. 1996; 6: 101 -11. PMID: 8791267 Click for abstract
  6. Li, M.F., Muller, J., Rao, M.V., Hearing, V., Lauders, K. and Gorelik, E. Loss of Intercistemal A type retroviral particles in B16 melanoma cells transfected with MHC class I genes. J. Gen. Virol. 1996; 77: 2757-65. PMID: 8922469 Click for abstract
  7. Rao, M.V., Donoghue, M.J., Merlie, J.P. and Sanes, J.R. Distinct regulatory elements control muscle specific, fiber type specific and axially graded expression of a myosin light chain gene in transgenic mice. Mol. Cell. Biol. 1996; 16:3909-22. PMID: 8668209 Full text available:
  8. Rao, M.V., Houseweart, M.K., Williamson, T.L., Crawford, T.O., Folmer, J. and Cleveland D.W. Neurofilament-dependent radial growth of motor axons and axonal Organization of neurofilaments does not require NF-H or its phosphorylation. J. Cell Biol. 1998; 143: 171-81. PMID: 9763429 Full text available:
  9. Duff, K., and Rao M.V. Progress in the modeling of neurodegenerative diseases in transgenic mice. Curr. Opinion Neurol. 2001; 14: 441-447. PMID: 11470959 Click for abstract
  10. Rao, M.V., Garcia, M.L., Miyazaki, Y., Gotow, T., Yuan, D., Mattina, S., Ward, C., Calcutt, N., Uchiyama, Y., Nixon, R.A., and Cleveland. D.W. Gene replacement in mice reveals that the heavily phosphorylated tail of NF-H does not affect axonal caliber or the transit of cargoes in slow axonal transport.  J. Cell Biol. 2002; 158:681-93. PMID: 12186852 Full text available:
  11. Rao, M.V., Engle, L.J., Mohan, P.S., Yuan. A., Qiu, D., Cataldo, A., Hassinger, L., Jacobsen, S., Lee, V.M.-Y., Andreadis, A., Julien, J. -P., Bridgman, P.C., and Ralph A. Nixon (2002b). Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J. Cell Biol. 2002; 159:279-89. PMID: 12403814 Full text available:
  12. Rao, M.V., Campbell, J., Yuan, D., Kumar, A., Gotow, T., Uchiyama, Y., and Nixon, R.A. The neurofilament middle molecular weight subunit carboxyl terminal tail domain is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate. J. Cell Biol. 2003; 163:1021-31. PMID: 14662746 Full text available:
  13. Yuan, D., Rao, M.V., Kumar, A., Julien, J.P., and Nixon, R.A. Neurofilament transport in vivo minimally requires hetero-oligomer formation. J. Neurosci. 2003; 23:9452-8. PMID: 14561875 Full text available:
  14. Rao, M.V., and Ralph. A. Nixon. Defective neurofilament transport in mouse models of Amyotrophic lateral sclerosis. Neurochem.  Res. 2003; 28:1041-47. PMID: 12737529 Click for abstract
  15. Yuan, A., Nixon, R.A., and Rao, M.V. Deleting the phosphorylated tail domain of the neurofilament heavy subunit does not alter neurofilament transport rate in vivo. Neurosci. Lett. 2006; 393:264-8. PMID: 16266786
  16. Yuan, A., Rao, M.V., Sasaki, T., Chen, Y., Kumar, A., Veeranna, Liem, R.K., Eyer, J., Julien, J.P., and Nixon, R.A. Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. J. Neurosci. 2006; 26:10006-19. PMID: 17005864 Full text available:
  17. Rao, M.V., Mohan, P.S., Peterhoff, C.M., Yang, D.S., Schmidt, S.D., Stavrides P.H., Campbell, J., Chen, Y., Jiang, Y., Paskevich, P.A., Cataldo, A.M.,  Haroutunian, V., and Nixon, R.A. Marked Calpastatin (CAST) depletion in Alzheimer’s disease accelerates cytoskeleton disruption and neurodegeneration: Neuroprotection by CAST overexpression. J. Neurosci. 2008; 29:11316-29. PMID: 19741138. Full text available:
  18. Garcia, M.L., Rao, M.V., Fujimoto, J., Garcia, V.B., Crum, J., Gotow, T., Uchiyama, Y., Ellisman, M., Calcutt, N.A., and Cleveland D.W. Neurofilament M KSP phosphorylation is not required for myelin-dependent radial axonal growth. J. Neurosci. 2009; 29:1277-84. PMID: 19193875. Full text available:
  19. Yuan, A., Sasaki, T., Rao, MV., Kumar, A., Kanumuri, V., Dunlop, DS., Liem, RK., and Nixon, RA. Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons. J Neurosci. 2009; 36:11316-29. PMID: 19741138. Full text available:
  20. Dyakin V, Chen Y, Branch CA, Veeranna, Yuan A, Rao M, Kumar A, Peterhoff C, Nixon RA.  The Contribution of myelin to brain white matter MRI transverse relaxation time (T2)Neuroimage, 2010; 51:1098-105. PMID: 20226865 Full text available:
  21. Rao MV, Mohan PS, Kumar A, Yuan A, Montagna L, Campbell J, Veeranna, Espreafico EM, Julien JP, Nixon RA. The Myosin Va Head Domain Binds to the Neurofilament-L Rod and Modulates Endoplasmic Reticulum (ER) Content and Distribution within Axons. PLoS One. 2011 6(2):e17087.PMID: 21359212. Full text available:
  22. Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA and Mathews PA. Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild type mice. Neurobiol. Aging 2012, 33(6):1125.e9-18. PMID: 22206846 PMCID:PMC3318946 Click for abstract Full text available:
  23. Yuan A, Sasaki T, Kumar S, Peterhoff C, Rao MV, Liem RK, Julien J-P, Nixon RA. Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and PNS axons. J Neurosci, 2012, 32(25):8501-8. PMID: 22723690 PMCID: PMC3405552 Click for abstract Full text available:
  24. Yuan A, Rao MV, Veeranna, Nixon RA. Neurofilaments at a glance. J Cell Sci,2012;125(Pt 14):3257-63. Click for abstract. Full text not available.
  25. Rao MV, Yuan A, Campbell J, Kumar S, Nixon RA. The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network. PLoS ONE, 2012, 7(9):e44320. PMID: 23028520 PMCID: PMC3448626 Full text available:
  26. Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S. Overexpression of the Calpain-specific Inhibitor Calpastatin reduceshuman alpha-Synuclein Processing, Aggregation and Synaptic Impairment in[A30P]αSyntransgenic mice. Hum Mol Genet, 2014, 23(15):3975-89. PMID:24619358 PMCID:PMC4110482 [Available on 2015/8/1] Click for abstract
  27. Rao MV, McBrayer MK, Campbell J, Kumar A, Hashim A, Sershen H, Stavrides PH, Ohno M, Hutton M, Nixon RA. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in Tau P301L mice J Neurosci, 2014, 34(28):9222-34. PMID:25009256 PMCID:PMC4087203 [Available on 2015/1/9] Click for abstract
  28. Menzies FM, Garcia-Arencibia M, Imarisio S, O’Sullivan NC, Ricketts T, Kent BA, Rao MV, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O’Kane CJ, Lam W, Rubinsztein DC. Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity. Cell Death Diff, 2014 Sept 26 [Epub ahead of print] PMC—In Process Click for abstract
  29. Yuan A, Hassinger L, Rao MV, Julien JP, Miller CC, Nixon RA. Dissociation of Axonal Neurofilament Content from Its Transport Rate. PLOS one, 2015 July 24; 10(7):e0133848 doi: 10.1371/journal.pone.0133848 PMID: 26208164 PMCID:4514674 Click for abstract
  30. Rao MV, Campbell J, Palaniappan A, Kumar A, Nixon RA. Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice. J Neurochem 2016 Apr;137(2):253-65. doi:10.1111/jnc.13536 PMID:26756888 Click for abstract
  31. Yuan A, Rao MV, Veeranna, Nixon RA. Neurofilaments and Neurofilament Proteins in Health and Disease. Cold Spring Harb Perspect Biol. 2017 Apr;3(4) doi: 10.1101/cshperspect.a18309 PMID: 28373358 Click for abstract

[last updated 2.8.18]