Publications for Helen Scharfman, PhD

Requests for papers can be made by emailing Helen Scharfman.

Original Publications

  1. Scharfman H.E. and Sarvey J.M. (1985) Postsynaptic firing during repetitive stimulation is required for long-term potentiation in hippocampus.  Brain Res. 331:267-274.
  2. Scharfman H.E. and Sarvey J.M. (1985) GABA sensitivity does not change during long-term potentiation in rat hippocampal slices. Neuroscience. 15:695-702.
  3. Scharfman H.E. and Sarvey J.M. (1985) Responses to g-aminobutyric acid applied to cell bodies and dendrites of rat visual cortical neurons.  Brain Res. 358:385-389.
  4. Scharfman H.E. and Sarvey J.M. (1987) Responses to g-aminobutyric acid (GABA) recorded from identified rat visual cortical neurons.  Neuroscience. 23:407-422.
  5. Scharfman H.E. and Sarvey J.M. (1988) Physiological correlates of responses to g-aminobutyric acid (GABA) recorded from rat visual cortical neurons in vitro.  Synapse. 2:619-626.
  6. Scharfman  H.E. and Schwartzkroin P.A. (1988) Electrophysiology of morphologically identified mossy cells of the rat dentate hilus.  J. Neurosci. 8:3412-3421. HTML PDF
  7. Scharfman H.E. and Schwartzkroin P.A. (1988) Further studies of somatostatin and related peptides in area CA1 of rabbit hippocampus studied in vitro.  Cell. and Mol. Neurobiol. 8:4ll-429.
  8. Scharfman H.E., Kunkel D.D. and Schwartzkroin P.A. (1989) Intracellular dyes mask immunoreactivity of hippocampal neurons.  Neurosci. Lett. 96:23-28.
  9. Scharfman  H.E. and Schwartzkroin P.A. (1989) Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampus. Brain Res. 493:205-211.
  10. Scharfman H.E. and Schwartzkroin P.A. (1989) Protection of dentate hilar mossy cells from prolonged stimulation by intracellular calcium chelation.  Science. 246:257-260.
  11. Scharfman H.E. and Schwartzkroin P.A. (1990) Responses of cells of the fascia dentata to prolonged stimulation of the perforant path: sensitivity of hilar cells and changes in granule cell excitability. Neuroscience. 35:491-504.
  12. Scharfman H.E. and Schwartzkroin P.A. (1990) Consequences of prolonged afferent stimulation of the rat fascia dentata: epileptiform activity in area CA3 of hippocampus. Neuroscience. 35:505-517.
  13. Scharfman H.E. and Schwartzkroin P.A. (1990) Synaptic connections of dentate granule cells and hilar neurons established by simultaneous intracellular recording in rat hippocampal slices. Neuroscience. 37:693-707.
  14. Scharfman H.E., Lu F.-S., Guido W., Adams P.R. and Sherman S.M. (1990) N-methyl-D-aspartate (NMDA) receptors contribute to EPSPs of cat lateral geniculate neurons recorded in thalamic slices. Proc. Natl. Acad. Sci. U.S.A. 86:1056-1060. HTML PDF
  15. Scharfman H.E. (1991) Dentate hilar cells with dendrites in the molecular layer have lower thresholds for synaptic activation by perforant path than granule cells. J. Neurosci. 11:1660-1673. HTML PDF
  16. Scharfman H.E. (1992) Blockade of excitation reveals inhibition in dentate spiny hilar cells of rat hippocampal slices. J. Neurophysiol. 68:978-984.
  17. Kunkel D.D., Scharfman H.E. and Schwartzkroin P.A. (1993) Electron microscopy of intracellularly labeled neurons in the hippocampal slice preparation. J. Elec. Microscop. Tech. 24:67-84.
  18. Scharfman H.E. (1993) Spiny neurons of area CA3c in rat hippocampal slices have similar electrophysiological properties and synaptic responses despite morphological variation. Hippocampus. 3:9-28.
  19. Scharfman H.E. (1993) Activation of dentate hilar neurons by stimulation of the fimbria in rat hippocampal slices. Neurosci. Lett. 156:61-66.
  20. Scharfman  H.E. (1993) Characteristics of spontaneous and evoked EPSPs recorded from dentate spiny hilar cells in rat hippocampal slices. J. Neurophysiol. 70:742-757.
  21. Scharfman H.E. (1994) Synchronization of area CA3 hippocampal pyramidal cells and non-granule cells of the dentate gyrus in bicuculline-treated rat hippocampal slices. Neuroscience. 59:245-257.
  22. Scharfman H.E. (1994) Paradoxical enhancement of GABAA receptor-mediated IPSPs of dentate granule cells by bicuculline in rat hippocampal slices. Neurosci. Lett. 168:29-33.
  23. Scharfman H.E. (1994) EPSPs of dentate gyrus granule cells synchronized with epileptiform bursts of dentate hilar mossy cells and area CA3 pyramidal cells in disinhibited rat hippocampal slices. J. Neurosci. 14:6041-6057. HTMLPDF
  24. Scharfman H.E. (1994) Evidence from simultaneous intracellular recordings in rat hippocampal slices that area CA3 pyramidal cells innervate dentate hilar mossy cells. J. Neurophysiol. 72:2167-2180.
  25. Scharfman H.E. (1995) Electrophysiological evidence that dentate hilar mossy cells innervate both granule cells and interneurons. J. Neurophysiol. 74:179-194.
  26. Scharfman H.E. (1995) Electrophysiological diversity of pyramidal-shaped neurons at the granule cell layer/hilus border of the rat dentate gyrus recorded in vitro.  Hippocampus. 5:287-305.
  27. Scharfman H.E. (1996) Conditions required for polysynaptic excitation of dentate granule cells by area CA3 pyramidal cells in rat hippocampal slices. Neuroscience. 72:655-668.
  28. Jackson M.B. and Scharfman H.E. (1996) Positive feedback from hilar mossy cells to granule cells in the dentate gyrus revealed by voltage-sensitive dye and microelectrode recording. J. Neurophysiol. 76:601-616.
  29. Scharfman H.E. (1997) Hyperexcitability of entorhinal cortex and hippocampus after application of amino-oxyacetic acid (AOAA) to medial entorhinal cortex in combined entorhinal and hippocampal slices.  J. Neurophysiol. 76:2986-3001.
  30. Scharfman H.E. and Ofer A.A. (1997) Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices. Neurosci. Lett. 224:115-118.
  31. Scharfman H.E. (1997) Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor. J. Neurophysiol. 78:1082-1095. HTML PDF
  32. Scharfman  H.E. and Goodman J.H. (1998) Effects of central and peripheral administration of kynurenic acid on hippocampal evoked responses in vivo and in vitro. Neuroscience. 86:751-764.
  33. Scharfman H.E., Goodman J.H., Du F. and Schwarcz R. (1998) Chronic changes in synaptic responses of entorhinal and hippocampal neurons after amino-oxyacetic acid (AOAA)- induced entorhinal cortical neuron loss. J. Neurophysiol. 80:3031-3046. HTML PDF
  34. Scharfman H.E., Goodman J.H. and Sollas A.L. (1999) Actions of BDNF in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus. J. Neurosci. 19:5619-5631. HTML PDF
  35. Croll S.D., Suri C., Compton D.L., Simmons M.V., Yancopoulos  G.D., Lindsay  R.M., Wiegand  S.J. and  Scharfman  H.E. (1999) Brain-derived neurotrophic factor (BDNF) transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience. 93:1491-1506. HTML PDF
  36. Scharfman H.E., Hodgkins P.S., Lee  S.-C. and Schwarcz  R.  (1999) Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices. Neurosci. Lett. 274:111-114.
  37. Wu H.Q., Guidetti P., Goodman J.H., Varasi M., Cersoli-Borroni G., Speciale C., Scharfman H.E. and Schwarcz R. (2000) Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo. Neuroscience. 97:243-251.
  38. Scharfman H.E., Goodman J.H. and Sollas A.L. (2000) Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis.  J. Neurosci. 20:6144-6158. HTML PDF
  39. Scharfman H.E., Smith K.S., Goodman J.H. and Sollas A.L. (2001) Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. Neuroscience. 104:741-759. HTML PDF
  40. Scharfman H.E., Sollas A.L. and Goodman J.H. (2001) Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus. Neuroscience. 111:71-81.
  41. Scharfman H.E., Goodman J.H., Sollas A.L. and Croll S.D. (2002) Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor (BDNF).  Exp. Neurol. 174:201-214.
  42. Wu H.Q., Lee S.C., Scharfman H.E. and Schwarcz R. (2002) L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat. Exp. Neurol. 177:1-11.
  43. Scharfman H.E., Goodman J.H., Sollas A.L., Smith K.L. and Jackson M.B. (2002) Structural and functional asymmetry in the normal and epileptic dentate gyrus. J. Comp. Neurol. 454:424-439. HTML PDF
  44. Howell O.W., Scharfman H.E., Beck-Sickinger A.G., Herzog H.H. and Gray W.P. (2003) Neuropeptide Y is neuroproliferative for hippocampal stem cells and neuroblasts.  J. Neurochem. 86:646-659.
  45. Scharfman H.E., Sollas A.L., Berger R.E. and Goodman J.H. (2003) Electrophysiological evidence of monosynaptic excitatory transmission between granule cells following seizure-induced mossy fiber sprouting. J. Neurophysiol. 90:2536-2547. HTML PDF
  46. Scharfman H.E., Sollas A.L., Berger R.E., Goodman J.H. and Pierce J.P. (2003) Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizures. Neuroscience. 121:1017-1029.
  47. Scharfman H.E., Mercurio T.C., Goodman J.H., Wilson M.A. and MacLusky N.J. (2003) Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor.  J. Neurosci. 23:11641-11652. HTML PDF
  48. Scharfman H.E., Goodman J.H., MacLeod A., Phani S., Antonelli C., and Croll S.D. (2005) Increased neurogenesis and ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Exp. Neurol. 192:348-356.
  49. Howell O.W., Doyle K., Goodman J.H., Scharfman H.E., Herzog H., Pringle A., Beck-Sickinger A.G. and Gray W.P. (2005) Neuropeptide Y stimulates neuronal precursor proliferation in the postnatal and adult dentate gyrus. J. Neurochem. 93:560-570.
  50. Wu H.Q., Rassoulpour A., Goodman J.H., Scharfman H.E., Bertram E.H., and Schwarcz R. (2005) Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats. Epilepsia.  46:1010-1016.
  51. Scharfman H.E., Goodman J.H., Rigoulot M.-A., Berger R.E., Walling S.G., Mercurio T.C., Stormes K.A. and MacLusky  N.J. (2005) Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine. Exp. Neurol. 196:73-86. HTML PDF
  52. McCloskey D.P., Croll S.D., Scharfman H.E. (2005) Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures. J. Neurosci. 25:8889-8897. HTML PDF
  53. Pierce J.P., Melton J., Punsoni, M., McCloskey D.P., and Scharfman H.E. (2005) Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures.  Exp. Neurol. 196:316-331. HTML PDF
  54. McCloskey D.P., Hintz T., Pierce J.P. and Scharfman H.E. (2006) Stereological estimation of the number of ectopic granule cells in the hilus following pilocarpine-induced status epilepticus. Eur. J. Neurosci. 24:2203-2210.
  55. Scharfman H.E., Goodman J.H., and McCloskey D.P. (2007) Ectopic granule cells of the rat dentate gyrus. Dev. Neurosci. 29:14-27.
  56. Howell O.W., Silva S., Scharfman H.E., Sosunov A.A., Zaben M., McKhann G.M., Lawskowski A., Gray, W.P. (2007) Neuropeptide Y is important for basal and seizure induced precursor cell proliferation in the hippocampus. Neurobiol. Dis. 26:174-188.
  57. Pierce J.P., Punsoni M., McCloskey D.P. and Scharfman H.E. (2007) Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures. Neuroscience Lett. 422:136-140. HTML PDF
  58. Scharfman H.E., Hintz T.M., Gomez J., Stormes K.A., Barouk S., Malthankar-Phatak G.H., McCloskey D.P., Luine V.N., and MacLusky N.J. (2007) Changes in hippocampal function in ovariectomized rats after sequential low doses of estradiol to simulate the preovulatory estrogen surge. Eur. J. Neurosci. 26:2595-612. HTML PDF
  59. Walling S.G., Rigoulot M.-A., and Scharfman H.E. (2007) Acute and chronic changes in glycogen phosphorylase in hippocampus and entorhinal cortex after status epilepticus in the adult male rat.  Eur. J. Neurosci. 26:178-189. HTML PDF
  60. Winawer M.R., Makarenko N, McCloskey D.P., Hintz T.M., Nair, N, Palmer A.A. and Scharfman H.E. (2007) Acute and chronic responses to the convulsant pilocarpine in DBA and A/J mice. Neuroscience. 149:465-475. HTML PDF
  61. MacBeth A.H., Scharfman H.E., MacLusky N.J. and Luine V.N. (2008) Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF). Horm Beh., 76:36-44. HTML PDF
  62. Nicoletti J.N., Shah S.K., McCloskey D.P., Goodman J.H., Elkady A., Atassi H., Hylton D., Rudge J.S., Scharfman H.E. and Croll S.D. (2008) Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience, 151:232-241. HTML PDF
  63. McCloskey D.P., Hintz T.M. and Scharfman H.E. (2008) Modulation of vascular endothelial growth factor (VEGF) expression in motor neurons and its electrophysiological effects.  Brain Res. Bull. 76:36-44. HTML PDF
  64. Scharfman H.E., Kim M., Hintz T.M., MacLusky N.J. (2008) Seizures and reproductive function: insights from female rats with epilepsy. Ann Neurol. 64:687-697. HTML PDF
  65. Scharfman H.E., Malthankar-Phatak G.H., Friedman D., Pearce P., McCloskey D.P., Harden C.L., MacLusky N.J. (2009) A rat model of epilepsy in women: a tool to study physiological interactiosn between endocrine systems and seizures. Endocrynology. 150:4437-4442. HTML
  66. Myers C.E., Scharfman H.E. (2009) The role of hilar neurons in pattern separation: a computational approach. Hippocampus. 19:321-337. HTML PDF
  67. Kimura A., Hsu M., Seldin M., Scharfman H.E., Binder D.K. (2010) Protective role of aquaporin-4 water channels following contusion spinal cord injury. Ann. Neurol. 67:794-801.
  68. Myers C.E., Scharfman H.E. (2010) Pattern separation in the dentate gyrus: A role for the CA3 backprojection. Hippocampus.
  69. Schroeder CE, Wilson DA, Radman T, Scharfman H, Lakatos P (2010) Dynamics of active sensing and perceptual selection. Curr Opin. Neurol. 20:172-176.
  70. Pierce, J.P., McCloskey, D.P., Scharfman, H.E. (2011) The morphometry of hilar ectopic granule cells. J. Comp. Neurol.,519:1196-218.
    73.
  71. Barouk S., Hintz, T., Li, P., Duffy, A.M., MacLusky N.J., Scharfman, H.E. (2011)17b-Estradiol increases astrocytic vascular endothelial growth factor (VEGF) in adult female rat hippocampus. Endocrinology, 152:1745-51. HTML PDF
  72. Duffy A.M., Schaner M.J., Wu S.H., Staniszewski A., Kumar A., Arevalo J-C., Arancio O., Chao M.V., Scharfman H.E. (2011) A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Exp Neurol., 229: 409-420. PMCID: PMC3100364HTMLPDF
  73. Skucas V., Mathews I.B., Yang J., Duffy A.M., Verkman A.S., Hempstead B.L., Wood M.A., Binder D.K., Scharfman H.E. (2011) Impairment in spatial memory and selective forms of synaptic plasticity after deletion of glial aquaproin-4. J. Neurosci., 31:6392-7. HTML PDF
  74. McCloskey D.P., Scharfman H.E. (2011) Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures. Epi. Res., 97(1-2):92-102. PMID: 21880468 PMC3215800 HTMLPDF
  75. Myers CE, Scharfman HE. (2011) Pattern separation in the dentate gyrus: a role for the CA3 backprojection. Hippocampus, 21(11):1190-215. PMID: 20683841
  76. Chakraborty G, Magagna-Poveda A, Parratt C, Umans JG, MacLusky NJ, Scharfman HE. Reduced hippocampal brain-derived neurotrophic factor (BDNF) in neonatal rats after prenatal exposure to propylthiouracil (PTU). Endocrinology, 153(3):1311-6. PMID: 22253429 PMCID: PMC3384077 [Available on 2013/3/1]
  77. Scharfman HE, Pierce JP. (2012) New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruciton. Epilepsia, 53 Suppl 1:109-15. PMID: 22612815
  78. Lee H, Dvorak D, Kao H-Y, Duffy AM, Scharfman HE, Fenton AA. (2012) Early cognitive experience prevents adult deficits in a neurodevelopmental schizophrenia model. Neuron, 75(4):714-24. PMID:22920261 PMCID:PMC3437240 [Free full text available 8/23/2013]
  79. Harte-Hargrove LC, Maclusky NJ, Scharfman HE. Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease. Neuroscience. 2013 Jun 3;239:46-66. doi: 10.1016/j.neuroscience.2012.12.029. Epub 2012 Dec 29. PubMed PMID: 23276673; PMCID: PMC3628287 [Available on 2014/6/3] Click for abstract
  80. Bath KG, Scharfman HE. Impact of early life exposure to antiepileptic drugs on neurobehavioral outcomes based on laboratory animal and clinical research. Epilepsy Behav. 2013 Mar;26(3):427-39. doi: 10.1016/j.yebeh.2012.10.031. Epub 2013 Jan 8. PubMed PMID: 23305780. Click for abstract
  81. Chin J, Scharfman HE. Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms. Epilepsy Behav. 2013 Mar;26(3):343-51. doi: 10.1016/j.yebeh.2012.11.040. Epub 2013 Jan 13. PubMed PMID: 23321057. Click for abstract
  82. Skucas VA, Duffy AM, Harte-Hargrove LC, Magagna-Poveda A, Radman T, Chakraborty G, Schroeder CE, MacLusky NJ, Scharfman HE. Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus. J Neurosci. 2013 Feb 6;33(6):2338-55. doi: 10.1523/JNEUROSCI.3857-12.2013. PubMed PMID: 23392664; PubMed Central PMCID: PMC3711621. Click for abstract PDF
  83. Myers CE, Bermudez-Hernandez K, Scharfman HE. The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function. PLoS One. 2013 Jun 28;8(6):e68208. doi: 10.1371/journal.pone.0068208. Print 2013. PubMed PMID: 23840835; PubMed Central PMCID: PMC3695928. Click for abstract PDF
  84. Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia. 2013 Aug;54 Suppl 4:44-60. doi: 10.1111/epi.12298. PubMed PMID: 23909853. Click for abstract
  85. Scharfman HE, Myers CE. Hilar mossy cells of the dentate gyrus: a historical perspective. Front Neural Circuits, 2013 Jan 9;6:106 doi:10.3389/fncir.2012.00106. PMID:23420672 PMCID: PMCID:PMC3572871. Click for abstract
  86. Duffy AM, Schaner MJ, Chin J, Scharfman HE. Expression of c-fos in hilar mossy cells of the dentate gyrus in vivo. Hippocampus. 2013, 23(8):649-55. doi: 10.1002/hipo.22138. PMID: 23640815 PMCID:PMC3732572 Click for abstract
  87. Pearce PS, Friedman D, Lafrancois JJ, Iyengar SS, Fenton AA, Maclusky NJ, Scharfman HE. Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy.Epilepsy Behav. 2014, 32:121-31. doi: 10.1016/j.yebeh.2014.01.004. PMID:24534480 [PubMed - in process] Click for abstract
  88. Yang J, Harte-Hargrove LC, Saio CJ, Marinic T, Clarke R, Ma Q, Jing D, LaFrancois JJ, Bath KG, Mark W, Ballon D, Lee FS, Scharfman HE, Hempstead BL. proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell Rep, 2014, 7(3):796-806. PMID: 24746813 PMCID: PMC4118923 [Available on 2015/5/8] Click for abstract
  89. VonDran MW, LaFrancois J, Padow VA, Friedman WJ, Scharfman HE, Milner TA, Hempstead BL. p75NTR, but not proNGF, is upregulated following status epilepticus in mice. ASN Neuro, 2014, 6(5). pii:1759091414552185. PMID:25290065 PMCID:PMC4187006 Click for abstract
  90. Scharfman HE, MacLusky NJ. Sex differences in the neurobiology of epilepsy: a preclinical perspective. Neurobiol Aging, 2014, 72Pt B: 180-92 PMID:25058745 PMCID: PMC4252793Click for abstract
  91. Scharfman HE, Brooks-Kayal AR 2014 Is plasticity of GABAergic mechanisms relevant to epileptogenesis? Adv Exp Med Biol, 2014 813:133-50 PMID:25012373 PMCID: PMC4370216 Click for abstract
  92. Harte-Hargrove LC, Varga-Wesson A, Duffy AM, Milner TA, Scharfman HE. Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat.J Neurosci. 2015 Jan 28;35(4):1723-38. doi: 10.1523/JNEUROSCI.0820-14.2015. PMID: 25632146
  93. Duffy AM, Morales-Corraliza J, Bermudez-Hernandez KM, Schaner MJ, Magagna-Poveda A, Mathews PM, Scharfman HE. Neurobiol Aging, 2015 36(1):134-48. PMID: 25109765 PMCID: PMC4268389 Click for abstract
  94. Iyengar SS, LaFrabcois JJ, Friedman D, Drew LJ, Denny CA, Burghardt NS, Wu MV , Hsieh J, Hen R, Scharfman HE. Suppression of adult neurogenesis increases the acute effects of kainic acid. Exp Neurol, 2015 264:135-49 PMID:2547694 PMCID:PMC4800819 Click for abstract
  95. Scharfman HE.Neuroscience. Metabolic control of epilepsy.Science. 2015 Mar 20;347(6228):1312-3. doi: 10.1126/science.aaa9607. No abstract available. PMID: 25792315
  96. Cho KO, Lybrand ZR, Ito N, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J.Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Cho KO, Lybrand ZR, Ito N, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J.Nat Commun. 2015 Mar 26;6:6606. doi: 10.1038/ncomms7606.PMID: 25808087
  97. Scharfman HE, Bernstein HL.Potential implications of a monosynaptic pathway from mossy cells to adult-born granule cells of the dentate gyrus.Front Syst Neurosci. 2015 Aug 19;9:112. doi: 10.3389/fnsys.2015.00112. eCollection 2015. Review.PMID: 26347618
  98. D'Amour J, Magagna-Poveda A, Moretto J, Friedman D, LaFrancois JJ, Pearce P, Fenton AA, MacLusky NJ, Scharfman HE.Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy.D'Amour J, Magagna-Poveda A, Moretto J, Friedman D, LaFrancois JJ, Pearce P, Fenton AA, MacLusky NJ, Scharfman HE.Exp Neurol. 2015 Jul;269:102-19. doi: 10.1016/j.expneurol.2015.04.003. Epub 2015 Apr 10.PMID: 25864929
  99. Kam K, Duffy ÁM, Moretto J, LaFrancois JJ, Scharfman HE.Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology.Sci Rep. 2016 Jan 28;6:20119. doi: 10.1038/srep20119.PMID: 26818394
  100. Blackstad JS, Osen KK, Scharfman HE, Storm-Mathisen J, Blackstad TW, Leergaard TB.Observations on hippocampal mossy cells in mink (Neovison vison) with special reference to dendrites ascending to the granular and molecular layers.Hippocampus. 2016 Feb;26(2):229-45. doi: 10.1002/hipo.22518. Epub 2015 Sep 12.PMID: 26286893
  101. Scharfman HE, Myers CE.Corruption of the dentate gyrus by "dominant" granule cells: Implications for dentate gyrus function in health and disease.Neurobiol Learn Mem. 2016 Mar;129:69-82. doi: 10.1016/j.nlm.2015.09.005. Epub 2015 Sep 29. Review.PMID: 26391451
  102. Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R.Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons.Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R.Hippocampus. 2016 Jun;26(6):763-78. doi: 10.1002/hipo.22557. Epub 2016 Feb 8. PMID: 26662922
  103. Scharfman HE.The enigmatic mossy cell of the dentate gyrus.Nat Rev Neurosci. 2016 Sep;17(9):562-75. doi: 10.1038/nrn.2016.87. Epub 2016 Jul 28. Review.PMID: 27466143
  104. Mendell AL, Atwi S, Bailey CD, McCloskey D, Scharfman HE, MacLusky NJ.Expansion of mossy fibers and CA3 apical dendritic length accompanies the fall in dendritic spine density after gonadectomy in male, but not female, rats.Brain Struct Funct. 2017 Jan;222(1):587-601. doi: 10.1007/s00429-016-1237-6. Epub 2016 Jun 9.PMID: 27283589
  105. Scharfman HE, MacLusky NJ.Sex differences in hippocampal area CA3 pyramidal cells.J Neurosci Res. 2017 Jan 2;95(1-2):563-575. doi: 10.1002/jnr.23927. Review. PMID: 27870399
  106. Bermudez-Hernandez K, Lu YL, Moretto J, Jain S, LaFrancois JJ, Duffy AM, Scharfman HE.Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX. Brain Struct Funct. 2017 Mar 17. doi: 10.1007/s00429-017-1391-5. [Epub ahead of print]PMID: 28314928
  107. Moretto JN, Duffy ÁM, Scharfman HE.Acute restraint stress decreases c-fos immunoreactivity in hilar mossy cells of the adult dentate gyrus.Moretto JN, Duffy ÁM, Scharfman HE.Brain Struct Funct. 2017 Jul;222(5):2405-2419. doi: 10.1007/s00429-016-1349-z. Epub 2017 Feb 11.PMID: 28190104
  108. Magagna-Poveda A, Moretto JN, Scharfman HE.Increased gyrification and aberrant adult neurogenesis of the dentate gyrus in adult rats. Brain Struct Funct. 2017 Dec;222(9):4219-4237. doi: 10.1007/s00429-017-1457-4. Epub 2017 Jun 27.PMID: 28656372
  109. You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J. Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits.Nat Med. 2017 Nov;23(11):1377-1383. doi: 10.1038/nm.4413. Epub 2017 Oct 16.PMID: 29035369
  110. Scharfman HE, Kanner AM, Friedman A, Blümcke I, Crocker CE, Cendes F, Diaz-Arrastia R, Förstl H, Fenton AA, Grace AA, Palop J, Morrison J, Nehlig A, Prasad A, Wilcox KS, Jette N, Pohlmann-Eden B. Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research? Epilepsy Behav. 2017 Oct 30. pii: S1525-5050(17)30763-1. doi:10.1016/j.yebeh.2017.09.016. [Epub ahead of print] Review.PMID: 29097123
  111. Harte-Hargrove LC, French JA, Pitkänen A, Galanopoulou AS, Whittemore V, Scharfman HE. Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 Nov;58 Suppl 4:78-86. doi: 10.1111/epi.13906. PMID: 29105074
  112. Kanner AM, Scharfman H, Jette N, Anagnostou E, Bernard C, Camfield C, Camfield P, Legg K, Dinstein I, Giacobbe P, Friedman A, Pohlmann-Eden B. Epilepsy as a Network Disorder (1): What can we learn from other network disorders such as autistic spectrum disorder and mood disorders? Epilepsy Behav. 2017 Dec;77:106-113. doi: 10.1016/j.yebeh.2017.09.014. Epub 2017 Oct 26. Review. PMID: 29107450
  113. Greenwood SG, Montroull L, Volosin M, Scharfman HE, Teng KK, Light M, Torkin R, Maxfield F, Hempstead BL, Friedman WJ. A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75 NTR- Sortilin Receptor Complex and Attenuates pro NGF-Induced Neuronal Death In Vitro and In Vivo. eNeuro 2018 Jan 17;5(1). doi: 10.1523/ENEURO.0257-17.2017. PMID: 29349290
  114. Scharfman HE. Controlling learning and epilepsy together. Science 2018 Feb;359(6377):740-741 doi:10.1126/science.aas8993 PMID:29449476
  115. Gorter JA, van Vilet EA, Dedeurwaerdere S, Buchanan GF, Friedman D, Borges K, Grabenstatter H, Lukasiuk K, Scharfman HE, Nehlig A. A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force. Epilepsia Open 2018 Oct 11;3(Suppl Suppl 1): 69-89 doi: 10.1002/epi4.12261 PMID: 30411072
  116. Scharfman HE, Galanopoulou AS, French JA, Pitkanen A, Whittemore V, Harte-Hargrove LC. Preclinical common data elements (CDEs) for eplepsy: A joint ILAE/AES and NINDS translational initiative. Epilepsia Open 2018 Jul 18;3(Suppl Suppl 1):9-12 doi: 10.1002/epi4.12235 PMID: 30450482
  117. Harte-Hargrove LC, Galanopoulou AS, French JA, Pitkanen A, Whittemore V, Scharfman HE. Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force. Epilepsia Open 2018 Jul 26;3(Suppl Suppl1): 13-23 doi: 10.1002/epi4.12234 PMID: 30450483
  118. Jain S, LaFrancois JJ, Botterill JJ, Alcantara-Gonzalez D, Scharfman HE. Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures. Hippocampus 2019 Jan 23 doi: 10.1002/hipo.23062

Reviews, Books, and Book Chapters

  1. Schwartzkroin P.A., Scharfman H.E. and Sloviter R.S. (1990) Similarities in circuitry between Ammon's horn and dentate gyrus: local interactions and parallel processing. Prog. Brain Res. 83:269-287.
  2. Scharfman H.E. (1992) Differentiation of rat dentate neurons by morphology and electrophysiology in hippocampal slices: granule cells, spiny hilar cells and aspiny, "fast-spiking" cells. In: The Dentate Gyrus and Its Role in Seizures. Eds: Ribak C.E., Gall C.  and Mody I. New York, Elsevier, pp. 93-109.
  3. Scharfman H.E. (1993) Pre- and postsynaptic actions of somatostatin in rat and rabbit hippocampal slices. In: Presynaptic Receptors in the CNS: Physiology and Pharmacology.  Eds: Dunwiddie T. and Lovinger D. Boston, Birkäuser, pp. 42-70.
  4. Scharfman H.E. (1999) The role of nonprincipal cells in dentate gyrus excitability and its relevance to animal models of epilepsy and temporal lobe epilepsy. In: Basic Mechanisms of the Epilepsies: Molecular and Cellular Approaches, Third edition.  Eds: Delgado-Esqueta A.V., Wilson W., Olsen R.W., and Porter R.J. New York, Lippincott-Raven, pp. 805-820.
  5. Scharfman  H.E., Witter M.P. and Schwarcz R., Eds. (2000) The Parahippocampal Region: Basic Science and Clinical Implications. New York, New York Academy of Sciences.
  6. Scharfman H.E., Goodman J.H. and Schwarcz R. (2000) Electrophysiological effects of exogenous and endogenous kynurenic acid in the rat brain: studies in vivo and in vitro. Amino Acids 19:283-297.
  7. Binder D.K., Croll S.D., Gall C.M. and Scharfman H.E. (2001) BDNF and epilepsy: too much of a good thing? Trends Neurosci. 24:47-53.
  8. Schwarcz R., Scharfman H.E. and Bertram E.H. (2001) Temporal lobe epilepsy: renewed emphasis on extrahippocampal areas.  In: ACNP 5th Generation of Progress. Eds: Davis K.L., Charney D., Coyle J.T. and Nemeroff C.  Lippincott Williams and Wilkins. pp. 1843-1855.
  9. Scharfman H.E. (2002) The parahippocampal region in temporal lobe epilepsy. In: The Parahippocampal Region: Organization and Role in Cognitive Functions.  Eds. Witter M.P. and Wouterlood F.G.  Oxford University Press, pp. 319-338.
  10. Scharfman H.E. (2002) Epilepsy as an example of neural plasticity. The Neuroscientist 8:155-174. HTML
  11. Scharfman H.E. (2002) Does the development of a GABAergic phenotype by hippocampal dentate gyrus granule cells contribute to epileptogenesis? Epilepsy Currents 2:63-65. HTML
  12. Scharfman H.E. (2002) Brain-derived neurotrophic factor enhances fast excitatory synaptic transmission in human epileptic dentate gyrus. Epilepsy Currents 2:93-94.
  13. Scharfman H.E. (2002) Grafts of encapsulated fibroblasts engineered to release an anticonvulsant substrate. Epilepsy Currents 2:125-126.
  14. Scharfman H.E. (2002) A novel animal model of epilepsy caused by inhibiting neuronal activity during development. Epilepsy Currents 2:127-128.
  15. Binder D.K. and Scharfman H.E, Eds. (2004) Recent Advances in Epilepsy Research. New York,Kluwer Press.
  16. Scharfman H.E. (2004) Functional implications of seizure-induced neurogenesis. In: Recent Advances in Epilepsy Research.  Eds.  Binder D.K. and  Scharfman H.E.  New York, Landes/Kluwer Press. HTML
  17. Croll S.D., Goodman J.H. and Scharfman H.E. (2004) VEGF and seizures: a double-edged Sword? In: Recent Advances in Epilepsy Research.  Eds.  Binder D.K. and  Scharfman H.E. New York, Landes/Kluwer Press. HTML
  18. Binder D.K. and Scharfman H.E. (2004) Brain-derived neurotrophic factor.  Growth Factors22:123-131. HTML
  19. Scharfman H.E. and MacLusky N.M. (2005) Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue? Trends Neurosci. 28:79-85.
  20. Croll S.D., McCloskey D.P., Nicoletti J.N. and Scharfman H.E. (2005) VEGF as a novel seizure therapeutic: killing two birds with one stone. In: Growth Factors and Epilepsy. Eds. Binder D.K. and Scharfman H.E. New York, Nova Sciences.
  21. Scharfman H.E. (2005) Seizure-induced neurogenesis and its dependence on growth factors and cytokines. In: Growth Factors and Epilepsy.  Eds. Binder D.K. and Scharfman H.E. New York, Nova Sciences.
  22. Binder D.K and  Scharfman, H.E., Eds. (2005) Growth Factors and Epilepsy. New York, Nova Sciences.
  23. Scharfman H.E. (2005) The absence of information  about hormones and absence. Epilepsy Currents 5:101-103. HTML
  24. Scharfman H.E. (2005) BDNF and epilepsy: a missing link? Epilepsy Currents 5:83-88. HTML
  25. Scharfman H.E. and MacLusky N.J. (2005) Similarities between BDNF and estrogen in hippocampus: coincidence or clue?  Trends Neurosci. 28:79-85.
  26. Stanton P.K., Bramham C.V. and Scharfman H.E., Eds. (2005) Synaptic plasticity and transsynaptic signaling. New York, Springer Science & Business Media.
  27. Scharfman H.E. and MacLusky N.J. (2006) Estrogen and BDNF: complexity of steroid hormone-growth factor interactions. Frontiers Neuroendocrinol. 27:415-435. HTML
  28. Scharfman H.E. and MacLusky N.J. (2006) The influence of gonadal hormones on excitability, seizures and epilepsy in the female. Epilepsia 47:1423-1440. HTML
  29. Scharfman H.E. and Pedley T.A. (2006) Temporal lobe epilepsy. In: The Neurobiology of Disease. Ed: Gilman, S. New York, Academic Press, pp. 349-370.
  30. Scharfman H.E. and Hen R. (2007) Is more neurogenesis better?  Science. 315:316-318. HTML
  31. Scharfman H.E, Ed. (2007) The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications. New York, Elsevier.
  32. Scharfman H.E. and Gray W.P. (2007) Relevance of seizure-induced neurogenesis to the etiology of temporal lobe epilepsy. Epilepsia. 48 (Suppl 2):33-41. HTML
  33. Scharfman H.E. and Schwarcz R. (2007) Neuromodulators in seizures, epileptogenesis, and epilepsy. In: Epilepsy: A Comprehensive Guide. Eds: Engel J., Pedley T.A., New York, Lippincott-Raven, pp. 289-306.
  34. Scharfman H.E. (2007) The neurobiology of epilepsy.  Curr Neurosci Res Rep. 7:348-354. HTML
  35. Scharfman H.E. (2007) The CA3 “backprojection" to the dentate gyrus. Prog Brain Res. 163:627-637. HTML
  36. Amaral D.G., Scharfman H.E., Levanex P. (2007) The dentate gyrus: fundamental neuroanatomical organization (the dentate gyrus for “dummies”). Prog Brain Res. 163:3-22. HTML
  37. Scharfman H.E., MacLusky N.J. (2008) Estrogen-growth factor interactions and their contributions to neurological disorders. Headache. 48:S77-S89. HTML
  38. Scharfman H.E. (2009) The role of neurotrophins in excitability in hippocampus and its potential relevance to epilepsy. In: The Encyclopedia of Basic Epilepsy Res. Ed: Schwartzkroin PA. New York: Elsevier.
  39. Scharfman H.E. (2009) Neurogenesis in the dentate gyrus and its potential role in epileptogenesis. In: The Encyclopedia of Basic Epilepsy Res. Ed: Schwartzkroin PA. New York: Elsevier.
  40. Scharfman H.E. and McCloskey D.P. (2009) Postnatal neurogenesis as a potential therapeutic target in epilepsy. Epilepsy Res. 85:150-161. HTML
  41. Schroeder C.E., Wilson D.A., Radman T., Scharfman H.E, Lakatos P. (2010) Dynamics of active sensing and perceptual selection. Curr Opin. Neurol. 20:172-176.
  42. Scharfman, H.E. (2010) Seizing an opportunity: a broader definition of epilepsy will lead to better treatment. Cerebrum,HTML
  43. McNamara J.O., Scharfman H.E. (2011) Multiple roles of the neurotrophin BDNF in epilepsy. In: Jasper’s Basic Mechanisms of the Epilepsies. Eds: Noebels J, Rogawski M, Avoli M, Olsen R, Delgado-Escueta A, in press.
  44. Scharfman HE. (2012) Alzheimer's disease and epilepsy: insight from animal models. Future Neruol., 7(2):177-92. PMCID: 22723738 HTML
  45. McNamara JO, Scharfman HE. (2012) Temporal lob epilepsy and the BDNF receptor, TrkB. In: Jasper's Basic Mechanisms of the Epilepsies [Internet]. Eds: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV. 4th edition. Bethesda, MD. PMID:22787630 HTML
  46. Scharfman HE. (2012) "Untangling" Alzheimer's disease and epilepsy. Epilepsy Curr. 2012 Sep;12(5):178-83. PMID:23118602 [PubMed] PMCID: PMC3482723 HTMLPDF
  47. Scharfman HE, Kramer EA, Luine V, Srivastava DP. (2012) Introduction to 'steroid hormone actions in the CNS: The role of brain-derived neurotrophic factor (BDNF)'Neuroscience. 2012 Nov 17. doi:pii: S0306-4522(12)01030-5. 10.1016/j.neuroscience.2012.10.022. [Epub ahead of print] No abstract available. PMID: 23164677
  48. Duffy AM, Schaner MJ, Chin J, Scharfman HE. Expression of c-fos in hilar mossy cells of the dentate gyrus in vivo. Hippocampus. 2013 Aug;23(8):649-55. doi: 10.1002/hipo.22138. Epub 2013 May 27. PMID: 23640815; PMCID: PMC3732572
    [Available on 2014/8/1] Click for abstract
  49. Scharfman HE, Myers CE. Hilar mossy cells of the dentate gyrus: a historical perspective. Front Neural Circuits. 2012;6:106. doi: 10.3389/fncir.2012.00106. Epub 2013 Jan 9. PubMed PMID: 23420672; PubMed Central PMCID: PMC3572871. Click for abstract PDF
  50. Scharfman HE, Maclusky NJ. Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats. Neuropharmacology. 2013 May 6. doi:pii: S0028-3908(13)00175-5. 10.1016/j.neuropharm.2013.04.029. [Epub ahead of print] PubMed PMID: 23660230. Click for abstract
  51. Scharfman HE. Preface to the special issue entitled "The future of translational epilepsy research". Epilepsy Behav. 2013 Mar;26(3):209. doi: 10.1016/j.yebeh.2012.12.016. Epub 2013 Jan 23. PubMed PMID: 23352321. No abstract available.
  52. Scharfman HE, Binder DK. Aquaporin-4 water channels and synaptic plasticity in the hippocampus. Neurochem Int. 2013 May 15. doi:pii: S0197-0186(13)00138-1. 10.1016/j.neuint.2013.05.003. [Epub ahead of print] PubMed PMID: 23684954. Click for abstract
  53. Scharfman HE, Kramár EA, Luine V, Srivastava DP. Introduction to 'steroid hormone actions in the CNS: the role of brain-derived neurotrophic factor (BDNF)'.Neuroscience. 2013, 239:1-2. doi: 10.1016/j.neuroscience.2012.10.022. PMID: 2316467 [No abstract available.]
  54. Scharfman HE. Cutting through the complexity: the role of brain-derived neurotrophic factor in post-traumatic epilepsy (Commentary on Gill et al.). Eur J Neurosci. 2013, 38(11):3552-3. doi: 10.1111/ejn.12419. PMID: 24289826 [PubMed - in process] [No abstract available.]
     
  55. Harte-Hargrove LC, Maclusky NJ, Scharfman HE. Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease.Neuroscience. 2013, 239:46-66. doi: 10.1016/j.neuroscience.2012.12.029. Epub 2012 Dec 29. Review. PMID: 23276673 Click for abstract
     
  56. Scharfman HE, MacLusky NJ. Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats. Neuropharmacology. 2014, 76 Pt C:696-708. doi: 10.1016/j.neuropharm.2013.04.029. Epub 2013 May 6. PMID: 23660230 [PubMed - in process] Click for abstract
  57. Duffy AM, Morales-Corraliza J, Bermudez-Hernandez KM, Schaner MJ, Magagna-Poveda A, Mathews PM, Scharfman HE. Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age. 2014 [Epub ahead of print] PMID:25109765 Click for abstract
  58. Scharfman HE, MacLusky NJ. Sex differences in the neurobiology of epilepsy: A preclinical perspective. Neurobiol Dis, 2014, 72PB:180-92. Review. PMID:25058745 Click for abstract
  59. Scharfman HE. Advances in understanding hilar mossy cells of the dentate gyrus.Cell Tissue Res. 2017 Dec 8. doi: 10.1007/s00441-017-2750-5. [Epub ahead of print] Review. PMID: 29222692

[last updated 02.25.19]