Publications for Dun Sheng Yang, PhD

Requests for papers can be made by emailing Dun Sheng.

Original Publications

  1. Yang DS, Smith JD, Zhou ZM, Gandy SE and Martins R (1997) Characterization of the binding of amyloid b peptide to cell cultured-derived native apolipoprotein E2, E3 and E4 isoforms and to isoforms from human plasma. J. Neurochem. 68:721-25. Full text available:
  2. Taddei K, Yang D, Fisher C, Clarnette R, Hallmayer J, Barnetson R, Maller R, Brooks WS, Whyte S, Nicholson GA, Masters CL, Broe GA, Gandy SE and Martins RN (1998) No association of presenelin-1 intronic polymorphism and Alzheimer’s disease in Australia. Neurosci. Lett. 246:178-180. Click for abstract
  3. Yang DS, Small DH, Seydel U, Smith JD, Hallmayer J, Gandy SE and Martins RN (1999) Apolipoprotein E promotes the binding and uptake of b-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neurosci. 90:1217-26. Click for abstract
    Kisilevsky R, Lemieux L, Boudreau L, Yang DS and Fraser P (1999) New clothes for amyloid enhancing factor (AEF): silk as AEF. Amyloid. 6:98-106. Click for abstract
  4. Yang DS, Yip CM, Huang THJ, Chakrabartty A and Fraser PE (1999) Manipulating the amyloid-b aggregation pathway with chemical chaperons. J. Biol. Chem. 74:32970-4. Full text available:
  5. Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer L, Sorbi S, Bruni A, Fraser P and St George-Hyslop P (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and bAPP processing. Nature 407:48-54. Click for abstract
  6. Chen FS, Yang DS, Petanceska S, Yang A., Tandon A., Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P and Fraser PE (2000) Carboxyl-terminal fragments of Alzheimer b-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1 deficient cells. J. Biol. Chem. 275:36794-802. Full text available:
  7. Huang THJ, Yang DS, Fraser PE and Chakrabartty A. (2000) Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: an in vitro model of preamyloid. J. Biol. Chem. 275:36436-40. Full text available:
  8. Qin KF, Yang DS, Yang Y, Chishti MA, Meng LJ, Kretzschmar HA, Yip CM, Fraser PE and Westaway D (2000) Copper(II)-induced conformational changes and protease-resistance in recombinant and cellular PrP: effect of protein age and deamidation. J. Biol. Chem. 275:19121-31. Full text available:
  9. Yang DS, McLaurin J, Qin K, Westaway D and Fraser PE (2000) Examining the zinc binding site of the amyloid-b peptide. Eur. J. Biochem. 267:6692-8. Full text available:
  10. Huang THJ, Yang DS, Plaskos NP, Go S, Yip CM, Fraser PE and Chakrabartty A. (2000) Structural studies of soluble oligomers of the Alzheimer b-amyloid peptide. J. Mol. Biol. 297:73-87. Click here for abstract
  11. McLaurin J, Yang DS, Yip CM and Fraser PE (2000) Modulating factors in amyloid-b fibril formation. J. Struct. Biol. 130:259-70. Click for abstract
  12. Fraser PE, Yang DS, Yu G, Levesque L, Nishimura M, Arawaka S, Serpell LC, Rogaeva E and St George-Hyslop P (2000) Presenilin structure, function and role in Alzheimer's disease. Biochim. Biophys. Acta 61944:1-15. Click for abstract
  13. Yang DS, Serpell LC, Yip CM, McLaurin J, Chrishti MA, Horne P, Boudreau L, Kisilevsky R, Westaway D and Fraser PE (2001) Assembly of Alzheimer’s amyloid-b fibrils and approaches for therapeutic intervention. Amyloid 8 Suppl 1:10-9. Click for abstract
  14. Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, St George-Hyslop P, Westaway D (2001) Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of APP695. J. Biol. Chem. 276:21562-70. Full text available:
  15. Zou WQ, Yang DS, Fraser PE, Cashman NR and Chakrabartty A (2001) All or none fibrillogenesis of a prion peptide. Eur. J. Biochem. 268:4885-91. Full text available:
  16. Fraser PE, Yu G, Levesque L, Nishimura M, Yang DS, Mount HTJ, Westaway D and St George-Hyslop P (2001) Presenilin function: connections to Alzheimer's disease and signal transduction. Biochem. Soc. Symp. 67:89-100. Click for abstract
  17. Serpell LC, McLaurin J, Yang DS, Sunde M, Yip CM, Fraser PE. (2001) Examining the molecular structure of Alzheimer's amyloid-beta protein. Amyloid 8 Suppl. 2:135-7.
  18. Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasagawa H, Duthie M, Schmidt S, Nixon RA. Ramabhadran TV, Mathews PM, Gandy SE, Mount HTJ, St George-Hyslop P, Fraser PE (2002) Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J. Biol. Chem. 277:28135-42. Full text available:
  19. Yang DS, Kumar A, Peterson J, Jeyathevan R, Peterhoff CM, Martins RN, Duff K, Cataldo AM, Ralph Nixon RA (2004) Neurodegeneration in a mouse model of Alzheimer’s disease (AD): Roles of apoptosis and autophagy. Neurobiol. Aging  25(10):S437
  20. Nixon RA, Yu WH, Cuervo AM, Cataldo AM, Mathews PM, Yang DS, Zheng P, Peterhoff CM, Kumar A, Jiang Y, Peterson J, Schmidt SD, Mohan P, Duff K, Hassinger L, Wegiel J, Lamb B (2004)  Autophagy in Alzheimer's disease pathogenesis. Neurobiol. Aging 25(10):S70-S71.
  21. Nixon RA, Yu WH, Cuervo AM, Kumar A, Yang DS, Peterhoff CM (2005) Autophagy in Alzheimer's Disease:  Failure of a Neuroprotective Mechanism. In: Alzheimer's Disease and Related Disorders: Research Advances (Khalid I, Winblad B, eds), pp190-201. Bucharest: "Ana Aslan" International Academy of Aging.
  22. Dyakin VV., Chen Y, Branch CA, Ardekani B, Yang DS, Guilfoil DN, Peterson J, Peterhoff C, Cataldo AM, Nixon RA (2006) In vivo MRI correlates of specific cholinergic circuitry loss in murine models of Down syndrome. Alzheimer's & Dementia2(3):S126-7.
  23. Lee S, Yang DS, Kumar A, Levy E, Hassinger L, Cataldo AM, Nixon RA (2006) In vivo turnover of retrogradely transported proteins by autophagy is impaired in PS/APP transgenic mice. Alzheimer's & Dementia2(3):S543.
  24. Yang DS, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M, Levy E, Cataldo AM, Nixon RA (2008) Neuronal apoptosis and autophagy crosstalk in aging PS/APP mice, a mouse model of Alzheimer's disease. Am. J. Pathol. 173:665-81. Full text available:
  25. Rao MV, Mohan PS, Peterhoff CM, Yang DS, Stavrides PH, Schmidt SD, Campbell J, Chen Y, Jiang Y, Maki M, Paskevich PA, Cataldo AM, Siman R, Haroutunian V, Nixon RA (2008) Marked Calpastatin Depletion in Alzheimer’s Disease Accelerates Cytoskeleton Disruption and Excitotoxicity: Neuroprotection by CAST Overexpression. J. Neurosci. 28:12241-54. Full text available:
  26. Yang DS, Stavrides P, Mohan P, Kumar A, Schmidt SD, Pawlik M, Bandyopadhyay U, Chishti MA, Yang AJ, Myers RM, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA (2008) Cystatin B deletion in a mouse model of Alzheimer's Disease, TgCRND8, ameliorates both autophagic-lysosomal and amyloid pathologies. Alzheimer's & Dementia 4(4):T223.
  27. Chen Y, Dyakin V, Branch CA, Ardekani B, Yang D, Guilfoyle DN, Peterson J, Peterhoff C, Ginsberg SD, Cataldo AM, Nixon RA (2009) In Vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiol. Aging  30:1453-65. Full text available:
  28. Yang DS, Lee JH, Nixon RA (2009) Monitoring autophagy in Alzheimer’s disease and related neurodegenerative diseases. Methods Enzymol. 453:111-44. Click for abstract
  29. Nixon RA, Lee JH, Yang DS, Yu WH, Stavrides P, Jiang Y, Lee S, Mohan PS (2009) Autophagy failure in Alzheimer disease: Genetic factors and pathological consequences. Autophagy 5(6):911.
  30. Veeranna, Yang DS, Lee JH, Vinod KY, Stavrides P, Amine ND, Pant HC, Nixon RA (2011) Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol. Aging 32:2016-29. Full text available:
  31. Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St. George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA (2011) Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain 134:258-77. Full text available:
  32. Xue X, Wang L-R, Sato Y, Jiang Y, Berg M, Yang D-S, Nixon RA, Liang X-J. Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer’s disease. Nano Lett, 2014, 14(9):5110-7.
    PMID:25115676 PMCID:PMC4160261 [Available on 2015/8/12] Click for abstract

Reviews, Books, and Book Chapters

  • Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA (2011) Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis. Autophagy 7:788-9. Full text available:
  • Nixon RA, Yang DS, Lee JH (2008) Neurodegenerative lysosomal disorders – a continuum from development to late age. Autophagy 4:590-9. Full text available:
  • Nixon RA, Yang DS (2011) Autophagy failure in Alzheimer’s disease – Locating the primary defect. Neurobiol. Dis. 43:38-45. Full text available:
  • Nixon RA, Yang DS. Autophagy and neuronal cell death in neurological disorders. In: Cell Survival and Cell Death. Baehrecke EH, Green DR, Kornbluth S, Salvesen GS (Eds.). Woodbury NY, USA: Cold Spring Harbor Laboratory Press. 4(10): pii: a008839. Click for abstract

[last updated 11.24.14]