The CDR has available 11,000 square feet of new space designed and equipped for studies on the biochemistry, molecular biology and morphology of the CNS, consisting of 6 laboratories, Electron Microscope (EM) and confocal microscopy facilities, darkrooms, 3 walk-in cold rooms, 4 tissue culture facilities, a glassware washing unit, segregated area for radioisotope studies, and tissue processing and histology facilities. The Geriatric Psychiatry Research Division includes 15 rooms. These include 2 separate examination rooms fully equipped with exam tables, ECG machines, and centrifuges for processing of biological samples. It also has 2 separate offices for neuropsychological assessment; 1 equipped with postural sway apparatus.
Electron Microscope (EM) Facility
Headed by EM Manager, Asok Kumar, PhD, the EM facility is a core facility that provides EM service to the investigators. It is equipped with a Philips CM10 Electron Microscope with Digital Imaging capabilities. Specimens are provided by the investigators. The results of studies are discussed with investigators and assist once provided to them for publication. Facility services include morphometric analyses based on a Bioquant VI system format, immunocytochemistry, as well as standard EM techniques. Advanced light microscopic analyses are offered with a Leica 2 channel, 3 laser confocal scanning microscope with the capacity for performing 3D and real-time capture imaging. The facility also provides diagnostic electron microscopy support to neighboring hospitals. The services of the facility are currently available to outside investigators on a fee-for-use basis.
NKI Health Sciences Library
Under library director, Stuart Moss, MLS, the Health Sciences Library of the Nathan Kline Institute offers an extensive array of mental health and biomedical information resources in both print and electronic formats. The research-oriented collection is particularly strong in psychiatry, neuroscience, and psychopharmacology. It includes over 300 current journal subscriptions, more than 25,000 bound journal volumes and books, as well as access to the entire MEDLINE and PsycINFO databases, and toNOVEL, the New York Online Virtual Electronic Library. The NKI Library is one of the best sources for psychiatric information in the Hudson valley region.
Center for Biomedical Imaging and Neuromodulation (C-BIN) (formerly CABI) has yielded the first images of the brain in transgenic mice modeling the pathology of Alzheimer’s disease. The sensitive detection of pathology in animal models has provided the basis for new neuro-imaging approaches to characterize patients with mild cognitive impairment or AD. The approximately 12,000 sq. ft. facility is centered around the technology of Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) and houses three state-of-the-art MR systems. Headed by Michael Milham, MD, PhD, C-BIN is divided into the Computational Neuroimaging Laboratory; Design, Acquisition and Stimulation Laboratory (DASL); and Medical Physics Laboratory (MPL). These subdivisions work together to understand the impact of psychiatric illnesses on developmental processes utilizing innovative MRI-based imaging approaches to characterize brain maturation across the lifespan.
The Genomics Facility at the Nathan Kline Institute has state-of-the-art instrumentation for molecular and cellular based operations, including single population cellular analyses. Dr. Ginsberg oversees the instrumentation that includes a new laser capture microdissection (LCM) system (Leica LMD 7000) which enables precise microaspiration of neurons and other cells from tissue sections. This instrumentation is critical for analyses at the NKI of vulnerable and relatively spared populations of neurons in neurodegenerative disorders including Alzheimer's disease (AD) and Down syndrome (DS), among others. Cells can be isolated from a wide variety of cell culture, animal model, and human postmortem brain tissue preparations. The NKI Genomics Facility also houses qPCR instrumentation and robotics for the generation of custom-designed microarray platforms. Please feel free to contact Dr. Ginsberg if you are interested in learning more about the instrumentation or the experiments that are conducted using these tools. For more details about our Genomics Facility, please click here.