Animal Facility

The Animal Facility is a shared resource that facilitates research through humane, ethical, and efficient management of animal populations and is overseen by the Institutional Animal Care and Use Committee (IACUC). The central animal facility encompasses 13,580 sq. ft. and provides a highly productive environment to conduct research studies in Alzheimer’s disease and other neurologic diseases. An attending veterinarian specializing in animal use in research trains the facility lab and animal technicians, as well as research staff. The attending veterinarian is directly responsible for the program of veterinary care and the humane use of animals in research. A full-time staff certified veterinary technician assists in health monitoring, treatment, and research support. A full program of occupational health and safety, to include consideration of rodent allergies, is integral to the program of animal care and use. The vivarium operates as a modified barrier facility and houses core genetically engineered mouse breeding colonies that supply experimental mouse models for studies. These colonies are used for studies of neuromolecular, physiology, behavior, and genetic mechanisms of spectrum disorders related to dementia, anxiety, autism, depression, seizures, and addiction, among others, in addition to the development of treatment for such disorders. Rodent surgery is performed in an equipped surgical suite comprised of a surgical room, animal prep room, scrub room, instrument cabinets, autoclaves, gas-anesthesia, scavenging equipment and stereotaxic apparatuses. The attending veterinarian either participates in or supervises surgeries and trains investigators and lab staff in specific techniques, including anesthesia and post-surgical analgesia and monitoring.

The current 7T animal MRI/S system is used in studies of rodent models of neuropsychiatric disorders. This 40 cm bore multinuclear imaging and spectroscopy (M.R.R.S spectrometer, Magnex magnet) system, with 2-channel capability is the current focal point of the animal research facility. Current studies performed on the 7T include diffusion measures in mice with hyaluronan deficiency, cuprizone-induced demyelination and a Ts2 model of down syndrome, as well as functional connectivity measures in a rat model of caregiver maltreatment. Proton spectroscopy studies have also been applied in models of Alzheimer’s disease, schizophrenia and chemogenetic stimulation (DREADDS). Current active protocols include quantitative cerebral blood flow (CBF) imaging in a mouse model of schizophrenia and development of a specialized acquisition for measurement of the pH-sensitive downfield resonances of the amide proteins.

NKI Health Sciences Library

Under library director, Stuart Moss, MLS, the Health Sciences Library of the Nathan Kline Institute offers an extensive array of mental health and biomedical information resources in both print and electronic formats. The research-oriented collection is particularly strong in psychiatry, neuroscience, and psychopharmacology. It includes over 300 current journal subscriptions, more than 25,000 bound journal volumes and books, as well as access to the entire MEDLINE and PsycINFO databases and, the New York Online Virtual Electronic Library (NOVEL). The NKI Library is one of the best sources for psychiatric information in the Hudson valley region.