Mathews and Levy Review Published in Frontiers in Neuroscience
New York – Research Scientists Paul Mathews and Efrat Levy of the CDR published a review discussing the emerging data arguing for an interdependence between exosome production and endosomal pathway integrity in the brain. In the piece, titled “Exosome Production Is Key to Neuronal Endosomal Pathway Integrity in Neurodegenerative Diseases,” the researchers propose that enhanced neuronal exosome secretion can be a protective response, reducing pathological disruption of the endosomal-lysosomal system in disease-vulnerable neurons. Mathews and Levy further state that developing therapeutic approaches that help to maintain or enhance neuronal exosome biogenesis and release may be beneficial in a range of disorders of the central nervous system.