Ju-Hyun Lee & Members of the Nixon Lab Publish Their Latest Research
New York – The February 2020 issue of Journal of Molecular Biology contains an article co-authored by Nixon Lab members led by Dr. Ju-Hyun Lee. The article, titled “β2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7,” explains findings that define a novel pathway for enhancing lysosomal acidification by mobilizing ClC-7 delivery to lysosomes. The researchers conclude that remediation of lysosomal function, especially by correcting acidification deficits, represents a promising avenue towards therapy in AD and possibly other neurodegenerative diseases.