New review by the CDR’s Ralph Nixon
New York – “The role of autophagy in neurodegenerative disease,” is the title of a new review penned by Dr. Ralph Nixon, Director of the Center for Dementia Research at the Nathan Kline Institute. The review, published in the August edition of Nature Magazine, provides an overview of the role of autophagy in neurodegenerative disease, focusing particularly on less frequently considered lysosomal clearance mechanisms and their considerable impact on disease. Various therapeutic strategies for modulating specific stages of autophagy and the current state of drug development for this purpose are also evaluated.